The following is a summary of just some of the published articles by members of the Center for Pediatric Research in Obesity and Metabolism.
Longitudinal Changes in Cardiac Structure and Function from Adolescence to Young Adulthood in Participants with Type 2 Diabetes Mellitus: The TODAY Follow-Up Study
TODAY Study Group: Gidding S, Braffett B, Shah RD, LimaJ, Doria de Vasconcellos H, Shah R, Nadeau KJ, Tryggestad JB, Hughan KS, Dhaliwal R, Levitt Katz, LE
Circulation Heart Failure
June 2020
Beta Cell Function and Insulin Sensitivity in Obese Youth with Maturity Onset Diabetes of Youth Mutations vs Type 2 Diabetes in TODAY: Longitudinal Observations and Glycemic Failure
Arslanian S, El Ghormli L, Haymond MH, Chan CL, Chernausek SD, Gandica RG, Gubitosi-Klug R, Levitsky LL, Siska M, Willi SM; TODAY Study Group
Pediatric Diabetes
June 2020
A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity
Kelly A, Auerbach P, Barrientos-Perez M, Gies I, Hale P, Marcus C, Mastrandrea L, Prabhu N, Arslanian S, NN8022-4180 Trial Investigators
New England Journal of Medicine
May 2020
Effect of Vitamin D3 Supplementation on Vascular and Metabolic Health of Vitamin D-deficient Overweight and Obese Children: A Randomized Clinical Trial
Rajakumar K, Moore CG, Khalid AT, Vallejo AN, Virji MA, Holick MF, Greenspan S, Arslanian S, Reis S
The American Journal of Clinical Nutrition
April 2020
β-cell Function, Incretin Response, and Insulin Sensitivity of Glucose and Fat Metabolism in Obese Youth: Relationship to OGTT Time to Glucose Peak
Kim JY, Tfayli H, Bacha F, Lee SJ, Michaliszyn SF, Yousuf S, Gebara N, Arslanian S
Pediatric Diabetes
February 2020
Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents with Type 2 Diabetes
Bjornstad P, Hughan K, Kelsey MM, Shah AS, Lynch J, Nehus E, Mitsnefes M, Jenkins T, Xu P, Xie C, Inge T, Nadeau K.
Diabetes Care
January 2020
Predictors of Response to Insulin Therapy in Youth with Poorly Controlled Type 2 Diabetes in the TODAY Trial
Bacha F, El ghormli L, Arslanian S, Zeitler P, Laffel L, Levitt Katz LE, Gandica R, Chang NT, Sprague JE, Macleish SA, TODAY Study Group
Pediatric Diabetes
November 2019
Obesity and Insulin Sensitivity Effects on Cardiovascular Risk Factors: Comparisons of Obese Dysglycemic Youth and Adults
RISE Consortium
Pediatric Diabetes
November 2019
Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.
Shah AS, El Ghormli L, Vajravelu ME, Bacha F, Farrell RM, Gidding SS, Levitt Katz LE, Tryggestad JB, White NH, Urbina EM and the TODAY Study Group
Diabetes Care
November 2019
Techniques to Assess Insulin Action in Youth
Michaliszyn SF and Arslanian S
In: Zeitler P., Nadeau K. (eds) Insulin Resistance. Contemporary Endocrinology. Humana, Cham
October 2019
Lack of Durable Improvements in β-Cell Function Following Withdrawal of Pharmacological Interventions in Adults with Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes
RISE Consortium
Diabetes Care
September 2019
Association of Habitual Daily Physical Activity with Glucose Tolerance and β-Cell Function in Adults with Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes from the Restoring Insulin Secretion (RISE) Study
RISE Consortium
Diabetes Care
August 2019
Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes with Metformin Alone or in Combination with Insulin Glargine on β-Cell Function: Comparison of Responses in Youth and Adults
RISE Consortium
Diabetes
August 2019
Association of Self-Reported Sleep and Circadian Measures with Glycemia in Adults with Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes
RISE Consortium
Diabetes Care
July 2019
Body Composition and Cardiorespiratory Fitness Between Metabolically Healthy Versus Metabolically Unhealthy Obese Black and White Adolescents
Lee SJ and Arslanian SA:
The Journal of Adolescent Health
March 2019
Effects of Exercise Modality on Insulin Resistance and Ectopic Fat in Adolescents with Overweight and Obesity: A Randomized Clinical Trial
Lee SJ, Libman I, Hughan K, Kuk J, Jeong J, Zhang D, Arslanian SA
The Journal of Pediatrics
March 2019
Adipose Tissue Insulin Resistance in Youth on the Spectrum from Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes
Kim JY, Bacha F, Tfayli H, Michaliszyn SF, Yousuf S, Arslanian S
Diabetes Care
February 2019
The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in β-cell Function in TODAY
Arslanian S, El Ghormli L, Kim JY, Bacha F, Chan C, Ismail H, Levitt Katz LE, Levitsky L, Tryggestad JB, White N, TODAY Study Group
Diabetes Care
January 2019
Pharmacokinetic and Pharmacodynamic Profile of the Sodium-glucose Co-transporter-2 Inhibitor Empagliflozin in Young People With Type 2 Diabetes: A Randomized Trial
Laffel LMB, Tamborlane WV, Yver A, Simons G, Wu J, Nock V, Hobson D, Hughan KS, Kaspers S, Marquard J
Diabetic Medicine
2018 Apr 14
Impaired Lipolysis, Diminished Fat oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome
Kim JY, Tfayli H, Michaliszyn S, Arslanian S
The Journal of Clinical Endocrinology & Metabolism
2018 Feb
Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT)
Kim JY, Nasr A, Tfayli H, Bacha F, Michaliszyn S, Arslanian S
Diabetes
2017 Dec
Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate
Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT
Hypertension
2017 Jul 24
Response to Letter “Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.”
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jun 6
Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jan 31
Adiponectin, Insulin Sensitivity, β-cell function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY
TODAY Study Group: Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond M, Levitsky L, Nadeau K, White N, Willi S
Diabetes Care
2017 Jan
The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth
Kim JY, Michaliszyn SF, Nasr A, Lee SJ, Tfayli H, Hannon T, Hughan KS, Bacha F, Arslanian S
Diabetes Care
2016 Aug
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice
Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH
Endocrinology
2016 Mar
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT
Circulation
2016 Feb 23
Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome
Hughan KS, Tfayli H, Warren-Ulanch JG, Barinas-Mitchell E, Arslanian S
Journal of Pediatrics
2016 Jan
The Changing Face of Diabetes in Youth: Lessons Learned from Studies of Type 2 Diabetes
Hannon T, Arslanian S
Annals of the New York Academy of Sciences
2015 Oct 8
β-cell Function, Incretin Effect and Incretin Hormones in Obese Youth along the Span of Glucose Tolerance from Normal to Prediabetes to Type 2 Diabetes
Michaliszyn S, Mari A, Lee S, Bacha F, Tfayli H, Farchoukh L, Ferrannini E, Arslanian S
Diabetes
2014 Nov
Coronary Artery Calcification in Obese Youth: What are the Phenotypic and Metabolic Determinants?
Bacha F, Edmundowicz D, Sutton-Tyrell K, Lee S, Tfayli H, Arslanian S
Diabetes Care
2014 Sep
Restoring Insulin Secretion (RISE): Design of Studies of β-Cell Preservation in Prediabetes and Early Type 2 Diabetes Across the Life Span
RISE Study Group: Nadeau K, Mather K, Arslanian S, Buchanan T, Caprio S, Edelstein S, Ehrmann, D, Savage P, Kahn S
Diabetes Care
2014 Mar
Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-Cell Function in TODAY
TODAY Study Group: Arslanian S, Pyle L, Payan M, Bacha F, Caprio S, Haymond M, Levitsky LL, Goland R, White N, Willi SM
Diabetes Care
2013 June 1
β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/obese Adolescents
Hughan KS, Bonadonna RC, Lee S, Michaliszyn SF, Arslanian SA
The Journal of Clinical Endocrinology & Metabolism
2013 May
FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH
Diabetes
2011 Nov
FoxO1 Mediates Insulin-dependent Regulation of Hepatic VLDL Production in Mice
Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M, Dong HH
The Journal of Clinical Investigation
2008 Jun 2
Foxo1 Mediates Insulin Action on apoC-III and Triglyceride Metabolism
Altomonte J, Cong L, Harbaran S, Richter A, Xu J, Meseck M, Dong HH
The Journal of Clinical Investigation
2004 Nov 15