"Redox lipidomics technology: Looking for a needle in a haystack". Tyurina YY, Tyurin VA, Anthonymuthu T, Amoscato AA, Sparvero LJ, Nesterova AM, Baynard ML, Sun W, He R, Khaitovich P, Vladimirov YA, Gabrilovich DI, Bayır H, Kagan VE. Chem Phys Lipids. 2019 Jul;221:93-107. doi: 10.1016/j.chemphyslip.2019.03.012. Epub 2019 Mar 27. Review.
Aiming for the target: Mitochondrial drug delivery in traumatic brain injury. Lamade AM, Kenny EM, Anthonymuthu TS, Soysal E, Clark RSB, Kagan VE, Bayır H. Neuropharmacology. 2019 Feb;145(Pt B):209-219. doi: 10.1016/j.neuropharm.2018.07.014. Epub 2018 Jul 30. Review.
Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow. Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayir H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS. In Vivo. 2019 May-Jun;33(3):675-688. doi: 10.21873/invivo.11526.
Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit. Ramgopal S, Dezfulian C, Hickey RW, Au AK, Venkataraman S, Clark RSB, Horvat CM. JAMA Netw Open. 2019 Aug 2;2(8):e199812. doi: 10.1001/jamanetworkopen.2019.9812.
Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J. J Neurosci. 2019 Mar 6;39(10):1930-1943. doi: 10.1523/JNEUROSCI.3415-17.2018. Epub 2019 Jan 9.
Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members. Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I. J Chem Inf Model. 2019 May 28;59(5):2496-2508. doi: 10.1021/acs.jcim.9b00006. Epub 2019 Feb 28.
Childhood brain tumors: current management, biological insights, and future directions. Pollack IF, Agnihotri S, Broniscer A. J Neurosurg Pediatr. 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. Review.
Clinical Utility of GlioSeq Next-Generation Sequencing Test in Pediatric and Young Adult Patients With Brain Tumors. Roy S, Agnihotri S, El Hallani S, Ernst WL, Wald AI, Santana Dos Santos L, Hamilton RL, Horbinski CM, Wadhwani NR, Born DE, Pollack IF, Nikiforov YE, Nikiforova MN. J Neuropathol Exp Neurol. 2019 Jun 10. doi: 10.1093/jnen/nlz055. [Epub ahead of print]
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma. Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V. J Clin Oncol. 2019 Apr 20;37(12):974-983. doi: 10.1200/JCO.18.01765. Epub 2019 Feb 27.
Conformal Radiation Therapy for Pediatric Patients with Low-Grade Glioma: Results from the Children's Oncology Group Phase 2 Study ACNS0221. Cherlow JM, Shaw DWW, Margraf LR, Bowers DC, Huang J, Fouladi M, Onar-Thomas A, Zhou T, Pollack IF, Gajjar A, Kessel SK, Cullen PL, McMullen K, Wellons JC, Merchant TE. Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):861-868. doi: 10.1016/j.ijrobp.2018.11.004. Epub 2018 Nov 10.
C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children. Horvat CM, Bell J, Kantawala S, Au AK, Clark RSB, Carcillo JA. Clin Pediatr (Phila). 2019 Jun;58(7):752-760. doi: 10.1177/0009922819837352. Epub 2019 Mar 31.
Detection of brain specific cardiolipins in plasma after experimental pediatric head injury. Anthonymuthu TS, Kenny EM, Hier ZE, Clark RSB, Kochanek PM, Kagan VE, Bayır H. Exp Neurol. 2019 Jun;316:63-73. doi: 10.1016/j.expneurol.2019.04.007. Epub 2019 Apr 11.
Development and Performance of Electronic Pediatric Risk of Mortality and Pediatric Logistic Organ Dysfunction-2 Automated Acuity Scores. Horvat CM, Ogoe H, Kantawala S, Au AK, Fink EL, Yablonsky E, Kochanek PM, Suresh S, Clark RSB. Pediatr Crit Care Med. 2019 Aug;20(8):e372-e379. doi: 10.1097/PCC.0000000000001998.
Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model. Di Caro V, Cummings JL, Alcamo AM, Piganelli JD, Clark RSB, Morowitz MJ, Aneja RK. Shock. 2019 Apr;51(4):526-534. doi: 10.1097/SHK.0000000000001180.
DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis. Simon DW, Halstead ES, Davila S, Kernan KF, Clark RSB, Storch G, Carcillo JA. J Pediatr. 2019 Oct;213:82-87.e2. doi: 10.1016/j.jpeds.2019.06.033. Epub 2019 Jul 11.
Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo. Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, Sterneckert JL. Stem Cell Reports. 2019 Mar 5;12(3):502-517. doi: 10.1016/j.stemcr.2019.01.015. Epub 2019 Feb 14.
Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis. Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T 3rd, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK. Shock. 2019 Sep 10. doi: 10.1097/SHK.0000000000001446. [Epub ahead of print]
Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia. Di Caro V, Alcamo AM, Cummings JL, Clark RSB, Novak EA, Mollen KP, Morowitz MJ, Aneja RK. PLoS One. 2019 Dec 2;14(12):e0224838. doi: 10.1371/journal.pone.0224838. eCollection 2019.
Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children. Hagos FT, Horvat CM, Au AK, Conley YP, Li L, Poloyac SM, Kochanek PM, Clark RSB, Empey PE. Clin Pharmacokinet. 2019 Dec;58(12):1567-1576. doi: 10.1007/s40262-019-00773-1.
Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H. Crit Care Med. 2019 Mar;47(3):410-418. doi: 10.1097/CCM.0000000000003555.
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy. Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J. Acta Neuropathol. 2019 Jul;138(1):67-84. doi: 10.1007/s00401-019-01998-x. Epub 2019 Apr 1.
Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Koncar RF, Dey BR, Stanton AJ, Agrawal N, Wassell ML, McCarl LH, Locke AL, Sanders L, Morozova-Vaske O, Myers MI, Hamilton RL, Carcaboso AM, Kohanbash G, Hu B, Amankulor NM, Felker J, Kambhampati M, Nazarian J, Becher OJ, James CD, Hashizume R, Broniscer A, Pollack IF, Agnihotri S. Cancer Res. 2019 Aug 15;79(16):4026-4041. doi: 10.1158/0008-5472.CAN-18-3521. Epub 2019 Jun 14.
Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing. Artyukhova MA, Tyurina YY, Chu CT, Zharikova TM, Bayır H, Kagan VE, Timashev PS. Free Radic Biol Med. 2019 Nov 20;144:279-292. doi: 10.1016/j.freeradbiomed.2019.06.007. Epub 2019 Jun 12. Review.
Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction? Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O, Jadhav S, Bolevich SB, Kozlov AV, Vladimirov YA, Shvedova AA, Philpott CC, Bayir H, Kagan VE. Free Radic Biol Med. 2019 Mar;133:153-161. doi: 10.1016/j.freeradbiomed.2018.09.008. Epub 2018 Sep 12. Review.
Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayır H. Crit Care Med. 2019 Apr;47(4):e292-e300. doi: 10.1097/CCM.0000000000003636.
Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications. Hagos FT, Adams SM, Poloyac SM, Kochanek PM, Horvat CM, Clark RSB, Empey PE. Exp Neurol. 2019 Jul;317:10-21. doi: 10.1016/j.expneurol.2019.02.011. Epub 2019 Feb 21. Review.
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB. Nat Commun. 2019 Dec 6;10(1):5583. doi: 10.1038/s41467-019-13383-z.
Opioid e-prescribing trends at discharge in a large pediatric health system. Horvat CM, Martin B, Wu L, Fabio A, Empey PE, Hagos F, Bigelow S, Kantawala S, Au AK, Kochanek PM, Clark RSB. J Opioid Manag. 2019 Mar/Apr;15(2):119-127. doi: 10.5055/jom.2019.0493.
Outcomes in children undergoing posterior fossa decompression and duraplasty with and without tonsillar reduction for Chiari malformation type I and syringomyelia: a pilot prospective multicenter cohort study. Koueik J, Sandoval-Garcia C, Kestle JRW, Rocque BG, Frim DM, Grant GA, Keating RF, Muh CR, Oakes WJ, Pollack IF, Selden NR, Tubbs RS, Tuite GF, Warf B, Rajamanickam V, Broman AT, Haughton V, Rebsamen S, George TM, Iskandar BJ. J Neurosurg Pediatr. 2019 Oct 18:1-9. doi: 10.3171/2019.8.PEDS19154. [Epub ahead of print]
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE. J Neurotrauma. 2019 Feb 1. doi: 10.1089/neu.2018.6203. [Epub ahead of print]
Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium. Ceschin R, Kocak M, Vajapeyam S, Pollack IF, Onar-Thomas A, Dunkel IJ, Poussaint TY, Panigrahy A. J Neurooncol. 2019 May;143(1):79-86. doi: 10.1007/s11060-019-03133-y. Epub 2019 Feb 27.
RASopathy in Patients With Isolated Sagittal Synostosis. Davis AA, Zuccoli G, Haredy MM, Losee J, Pollack IF, Madan-Khetarpal S, Goldstein JA, Nischal KK. Glob Pediatr Health. 2019 May 12;6:2333794X19846774. doi: 10.1177/2333794X19846774. eCollection 2019.
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. Nature. 2019 Oct;574(7780):707-711. doi: 10.1038/s41586-019-1650-0. Epub 2019 Oct 9.
Redox (phospho)lipidomics of signaling in inflammation and programmed cell death. Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE. J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. Epub 2019 May 9. Review.
Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death. Kagan VE, Tyurina YY, Sun WY, Vlasova II, Dar H, Tyurin VA, Amoscato AA, Mallampalli R, van der Wel PCA, He RR, Shvedova AA, Gabrilovich DI, Bayir H. Free Radic Biol Med. 2020 Feb 1;147:231-241. doi: 10.1016/j.freeradbiomed.2019.12.028. Epub 2019 Dec 25. Review.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27.
Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level. Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H, Kagan VE, Winograd N. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. doi: 10.1002/anie.201814256. Epub 2019 Feb 14.
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial. Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M. Lancet Oncol. 2019 Jul;20(7):1011-1022. doi: 10.1016/S1470-2045(19)30277-3. Epub 2019 May 28.
Serial Visual Evoked Potentials in Patients with Craniosynostosis and Invasive Intracranial Pressure Monitoring. Haredy MM, Liasis A, Fu V, Davis A, Pollack IF, Losee JE, Saied S, Nischal KK, Goldstein JA. Plast Reconstr Surg. 2019 Sep;144(3):446e-452e. doi: 10.1097/PRS.0000000000005935.
The Incidence of Chiari Malformations in Patients with Isolated Sagittal Synostosis. Davis AA, Zuccoli G, Haredy MM, Runkel L, Losee J, Pollack IF, Tamber MS, Tyler-Kabara E, Goldstein JA, Nischal KK. Plast Reconstr Surg Glob Open. 2019 Feb 12;7(2):e2090. doi: 10.1097/GOX.0000000000002090. eCollection 2019 Feb.