"Take a Number"-Precision Monitoring Directs Precision Therapy. Kochanek PM, Jha RM, Clark RSB. Neurocrit Care. 2020 Mar 5. doi: 10.1007/s12028-020-00941-3. [Epub ahead of print] No abstract available.
Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis.Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayir H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS. Radiat Res. 2020 Mar 5. doi: 10.1667/RR15486.1. [Epub ahead of print]
Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass. Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayír H. Pediatr Crit Care Med. 2020 Jan;21(1):33-41. doi: 10.1097/PCC.0000000000002036.
Early Hyperoxemia and Outcome Among Critically Ill Children. Ramgopal S, Dezfulian C, Hickey RW, Au AK, Venkataraman S, Clark RSB, Horvat CM. Pediatr Crit Care Med. 2020 Feb;21(2):e129-e132. doi: 10.1097/PCC.0000000000002203.
Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333. Reddy AT, Strother DR, Judkins AR, Burger PC, Pollack IF, Krailo MD, Buxton AB, Williams-Hughes C, Fouladi M, Mahajan A, Merchant TE, Ho B, Mazewski CM, Lewis VA, Gajjar A, Vezina LG, Booth TN, Parsons KW, Poss VL, Zhou T, Biegel JA, Huang A. J Clin Oncol. 2020 Feb 27:JCO1901776. doi: 10.1200/JCO.19.01776. [Epub ahead of print]
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Nat Chem Biol. 2020 Mar;16(3):278-290. doi: 10.1038/s41589-019-0462-8. Epub 2020 Feb 17.
Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death. Kagan VE, Tyurina YY, Sun WY, Vlasova II, Dar H, Tyurin VA, Amoscato AA, Mallampalli R, van der Wel PCA, He RR, Shvedova AA, Gabrilovich DI, Bayir H. Free Radic Biol Med. 2020 Feb 1;147:231-241. doi: 10.1016/j.freeradbiomed.2019.12.028. Epub 2019 Dec 25. Review.
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE.Nat Chem Biol. 2020 Mar;16(3):278-290. doi: 10.1038/s41589-019-0462-8. Epub 2020 Feb 17.PMID: 32080625
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. Bayır H, Anthonymuthu TS, Tyurina YY, Patel SJ, Amoscato AA, Lamade AM, Yang Q, Vladimirov GK, Philpott CC, Kagan VE.Cell Chem Biol. 2020 Apr 16;27(4):387-408. doi: 10.1016/j.chembiol.2020.03.014. Epub 2020 Apr 9.PMID: 32275865 Review.
Mitochondrial damage & lipid signaling in traumatic brain injury. Lamade AM, Anthonymuthu TS, Hier ZE, Gao Y, Kagan VE, Bayır H.Exp Neurol. 2020 Jul;329:113307. doi: 10.1016/j.expneurol.2020.113307. Epub 2020 Apr 11.PMID: 32289317 Review.
Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis. Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC.Hepatology. 2020 May 21. doi: 10.1002/hep.31328. Online ahead of print.PMID: 32438524
PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells. Zhao J, Dar HH, Deng Y, St Croix CM, Li Z, Minami Y, Shrivastava IH, Tyurina YY, Etling E, Rosenbaum JC, Nagasaki T, Trudeau JB, Watkins SC, Bahar I, Bayır H, VanDemark AP, Kagan VE, Wenzel SE.Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14376-14385. doi: 10.1073/pnas.1921618117. Epub 2020 Jun 8.PMID: 32513718 Free PMC article.
Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis. Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayir H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS.Radiat Res. 2020 May;193(5):435-450. doi: 10.1667/RR15486.1. Epub 2020 Mar 5.PMID: 32134361
Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study. Fink EL, Clark RSB, Panigrahy A, Berger R, Wisnowski J, Bluml S, Maloney D, Rubin P, Haller T, Bayir H, Beers SR, Kochanek PM, Fabio A; POCCA Investigators.BMJ Open. 2020 Oct 27;10(10):e039323. doi: 10.1136/bmjopen-2020-039323.PMID: 33109667 Free PMC article.
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.J Neurotrauma. 2020 Nov 15;37(22):2353-2371. doi: 10.1089/neu.2018.6203. Epub 2019 Feb 1.PMID: 30520681
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis. Wiernicki B, Dubois H, Tyurina YY, Hassannia B, Bayir H, Kagan VE, Vandenabeele P, Wullaert A, Vanden Berghe T.Cell Death Dis. 2020 Oct 27;11(10):922. doi: 10.1038/s41419-020-03118-0.PMID: 33110056 Free PMC article.
Preclinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases. LaPlaca MC, Huie JR, Alam HB, Bachstetter AD, Bayir H, Bellgowan PSF, Cummings D, Dixon CE, Ferguson AR, Ferland-Beckham C, Floyd C, Friess S, Galanopoulou A, Hall ED, Harris NG, Hawkins BE, Hicks R, Hulbert LE, Johnson VE, Kabitzke P, Lafrenaye AD, Lemmon V, Lifshitz C, Lifshitz J, Loane DJ, Misquitta L, Nikolian VC, Noble L, Smith DH, Taylor-Burds C, Umoh N, Vovk O, Williams AM, Young M, Zai L.J Neurotrauma. 2020 Dec 10. doi: 10.1089/neu.2020.7328. Online ahead of print.PMID: 33297844
Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass. Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayír H.Pediatr Crit Care Med. 2020 Jan;21(1):33-41. doi: 10.1097/PCC.0000000000002036.PMID: 31305328 Free PMC article.
Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, Kagan VE.Redox Biol. 2021 Jan;38:101744. doi: 10.1016/j.redox.2020.101744. Epub 2020 Oct 16.PMID: 33126055 Free PMC article.
Pediatric Low-Grade Gliomas. Collins KL, Pollack IF.Cancers (Basel). 2020 May 4;12(5):1152. doi: 10.3390/cancers12051152.PMID: 32375301 Free PMC article. Review.
Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma. Zou H, Poore B, Broniscer A, Pollack IF, Hu B.Cancers (Basel). 2020 Mar 10;12(3):643. doi: 10.3390/cancers12030643.PMID: 32164294 Free PMC article. Review.
Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Cooney TM, Cohen KJ, Guimaraes CV, Dhall G, Leach J, Massimino M, Erbetta A, Chiapparini L, Malbari F, Kramer K, Pollack IF, Baxter P, Laughlin S, Patay Z, Young Poussaint T, Warren KE.Lancet Oncol. 2020 Jun;21(6):e330-e336. doi: 10.1016/S1470-2045(20)30166-2.PMID: 32502459 Review.
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang HY, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang LB, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium.Cell. 2020 Dec 23;183(7):1962-1985.e31. doi: 10.1016/j.cell.2020.10.044. Epub 2020 Nov 25.PMID: 33242424 Free article.
Reply to S.A. Upadhyaya. Reddy AT, Krailo MD, Buxton AB, Strother DR, Huang A, Zhou T, Judkins AR, Burger PC, Pollack IF, Williams-Hughes C, Fouladi M, Ho B, Mazewski CM, Lewis VA, Vezina LG, Booth TN, Mahajan A.J Clin Oncol. 2020 Oct 1;38(28):3353-3354. doi: 10.1200/JCO.20.01573. Epub 2020 Jul 30.PMID: 32730180 No abstract available.
Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333. Reddy AT, Strother DR, Judkins AR, Burger PC, Pollack IF, Krailo MD, Buxton AB, Williams-Hughes C, Fouladi M, Mahajan A, Merchant TE, Ho B, Mazewski CM, Lewis VA, Gajjar A, Vezina LG, Booth TN, Parsons KW, Poss VL, Zhou T, Biegel JA, Huang A.J Clin Oncol. 2020 Apr 10;38(11):1175-1185. doi: 10.1200/JCO.19.01776. Epub 2020 Feb 27.PMID: 32105509
Decompressive Cranial Vault Remodeling in Osteosclerotic Robinow Syndrome. Herman PI, Marji FP, Anstadt EE, Dvoracek LA, Goldstein JA, Pollack IF, Losee JE.Cleft Palate Craniofac J. 2021 Jan;58(1):126-130. doi: 10.1177/1055665620946573. Epub 2020 Aug 6.PMID: 32757781
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. Nobre L, Zapotocky M, Khan S, Fukuoka K, Fonseca A, McKeown T, Sumerauer D, Vicha A, Grajkowska WA, Trubicka J, Li KKW, Ng HK, Massimi L, Lee JY, Kim SK, Zelcer S, Vasiljevic A, Faure-Conter C, Hauser P, Lach B, van Veelen-Vincent ML, French PJ, Van Meir EG, Weiss WA, Gupta N, Pollack IF, Hamilton RL, Nageswara Rao AA, Giannini C, Rubin JB, Moore AS, Chambless LB, Vibhakar R, Ra YS, Massimino M, McLendon RE, Wheeler H, Zollo M, Ferruci V, Kumabe T, Faria CC, Sterba J, Jung S, López-Aguilar E, Mora J, Carlotti CG, Olson JM, Leary S, Cain J, Krskova L, Zamecnik J, Hawkins CE, Tabori U, Huang A, Bartels U, Northcott PA, Taylor MD, Yip S, Hansford JR, Bouffet E, Ramaswamy V.Cell Rep Med. 2020 Jun 23;1(3):100038. doi: 10.1016/j.xcrm.2020.100038.PMID: 32743560 Free PMC article.
Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance.
Jane EP, Premkumar DR, Thambireddy S, Golbourn B, Agnihotri S, Bertrand KC, Mack SC, Myers MI, Chattopadhyay A, Taylor DL, Schurdak ME, Stern AM, Pollack IF.Mol Cancer Res. 2020 Jul;18(7):1004-1017. doi: 10.1158/1541-7786.MCR-19-0669. Epub 2020 Apr 1.PMID: 32238439 Free PMC article.
Evaluation of the Patient-Practitioner Consultation on Surgical Treatment Options for Patients With Craniosynostosis.
Pfeifauf KD, Said AM, Naidoo SD, Skolnick GB, Kestle JRW, Lee A, Birgfeld C, Anderson RCE, Gociman B, Siddiqi FA, Pollack IF, Goldstein JA, Tamber M, Imahiyerobo T, Smyth MD, Patel KB; Synostosis Research Group.J Craniofac Surg. 2020 Jul-Aug;31(5):1186-1190. doi: 10.1097/SCS.0000000000006327.PMID: 32634133
Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.
Goldman S, Pollack IF, Jakacki RI, Billups CA, Poussaint TY, Adesina AM, Panigrahy A, Parsons DW, Broniscer A, Robinson GW, Robison NJ, Partap S, Kilburn LB, Onar-Thomas A, Dunkel IJ, Fouladi M.Neuro Oncol. 2020 Nov 26;22(11):1696-1704. doi: 10.1093/neuonc/noaa119.PMID: 32393959
Surgical resource utilization after initial treatment of infant hydrocephalus: comparing ETV, early experience of ETV with choroid plexus cauterization, and shunt insertion in the Hydrocephalus Clinical Research Network. Pindrik J, Riva-Cambrin J, Kulkarni AV, Alvey JS, Reeder RW, Pollack IF, Wellons JC, Jackson EM, Rozzelle CJ, Whitehead WE, Limbrick DD, Naftel RP, Shannon C, McDonald PJ, Tamber MS, Hankinson TC, Hauptman JS, Simon TD, Krieger MD, Holubkov R, Kestle JRW; Hydrocephalus Clinical Research Network.J Neurosurg Pediatr. 2020 Jun 19:1-9. doi: 10.3171/2020.4.PEDS19632. Online ahead of print.PMID: 32559741
Predictors of fast and ultrafast shunt failure in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study. Hauptman JS, Kestle J, Riva-Cambrin J, Kulkarni AV, Browd SR, Rozzelle CJ, Whitehead WE, Naftel RP, Pindrik J, Limbrick DD, Drake J, Wellons JC, Tamber MS, Shannon CN, Simon TD, Pollack IF, McDonald PJ, Krieger MD, Chu J, Hankinson TC, Jackson EM, Alvey JS, Reeder RW, Holubkov R; Hydrocephalus Clinical Research Network.J Neurosurg Pediatr. 2020 Dec 18:1-10. doi: 10.3171/2020.7.PEDS20111. Online ahead of print.PMID: 33338993
"Take a Number"-Precision Monitoring Directs Precision Therapy. Kochanek PM, Jha RM, Clark RSB.Neurocrit Care. 2020 Jun;32(3):683-686. doi: 10.1007/s12028-020-00941-3.PMID: 32141034 No abstract available.
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients. DeKosky ST, Kochanek PM, Valadka AB, Clark RSB, Chou SH, Au AK, Horvat C, Jha RM, Mannix R, Wisniewski SR, Wintermark M, Rowell SE, Welch RD, Lewis L, House S, Tanzi RE, Smith DR, Vittor AY, Denslow ND, Davis MD, Glushakova OY, Hayes RL.J Neurotrauma. 2021 Jan 1;38(1):1-43. doi: 10.1089/neu.2020.7332. Epub 2020 Nov 11.PMID: 33115334 Free PMC article.
Early Hyperoxemia and Outcome Among Critically Ill Children. Ramgopal S, Dezfulian C, Hickey RW, Au AK, Venkataraman S, Clark RSB, Horvat CM.Pediatr Crit Care Med. 2020 Feb;21(2):e129-e132. doi: 10.1097/PCC.0000000000002203.PMID: 31821205 Free PMC article.
Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept. Wolf MS, Rakkar J, Horvat CM, Simon DW, Kochanek PM, Clermont G, Clark RSB.Neurocrit Care. 2020 Jun 15:1-9. doi: 10.1007/s12028-020-01004-3. Online ahead of print.PMID: 32556856 Free PMC article.
Depletion of gut microbiota is associated with improved neurologic outcome following traumatic brain injury. Simon DW, Rogers MB, Gao Y, Vincent G, Firek BA, Janesko-Feldman K, Vagni V, Kochanek PM, Ozolek JA, Mollen KP, Clark RSB, Morowitz MJ.Brain Res. 2020 Nov 15;1747:147056. doi: 10.1016/j.brainres.2020.147056. Epub 2020 Aug 13.PMID: 32798452
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.J Neurotrauma. 2020 Nov 15;37(22):2353-2371. doi: 10.1089/neu.2018.6203. Epub 2019 Feb 1.PMID: 30520681
Maximum Pao2 in the First 72 Hours of Intensive Care Is Associated With Risk-Adjusted Mortality in Pediatric Patients Undergoing Mechanical Ventilation. Pelletier JH, Ramgopal S, Au AK, Clark RSB, Horvat CM.Crit Care Explor. 2020 Sep 14;2(9):e0186. doi: 10.1097/CCE.0000000000000186. eCollection 2020 Sep.PMID: 32984827 Free PMC article.
Feasibility and Performance of a Gel-Adhesive Pad System for Pediatric Targeted Temperature Management: An Exploratory Analysis of 19 Pediatric Critically Ill Patients. Alcamo AM, Lavezoli R, Dezfulian C, Simon DW, Aneja RK, Clark RSB, Kochanek PM, Fink EL.Ther Hypothermia Temp Manag. 2020 May 19. doi: 10.1089/ther.2020.0011. Online ahead of print.PMID: 32429750
Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study. Fink EL, Clark RSB, Panigrahy A, Berger R, Wisnowski J, Bluml S, Maloney D, Rubin P, Haller T, Bayir H, Beers SR, Kochanek PM, Fabio A; POCCA Investigators.BMJ Open. 2020 Oct 27;10(10):e039323. doi: 10.1136/bmjopen-2020-039323.PMID: 33109667 Free PMC article.
Intracranial and Cerebral Perfusion Pressure Thresholds Associated With Inhospital Mortality Across Pediatric Neurocritical Care. Woods KS, Horvat CM, Kantawala S, Simon DW, Rakkar J, Kochanek PM, Clark RSB, Au AK.Pediatr Crit Care Med. 2020 Nov 23. doi: 10.1097/PCC.0000000000002618. Online ahead of print.PMID: 33229873
Factors Associated With Neurobehavioral Complications in Pediatric Abdominal Organ Transplant Recipients Identified Using Computable Composite Definitions. Alcamo AM, Clark RSB, Au AK, Kantawala S, Yablonsky EJ, Sindhi R, Mazariegos GV, Aneja RK, Horvat CM.Pediatr Crit Care Med. 2020 Sep;21(9):804-810. doi: 10.1097/PCC.0000000000002355.PMID: 32343104
Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated with Microglial Activation in a Mouse Model of Sepsis. Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T 3rd, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK.Shock. 2020 Aug;54(2):256-264. doi: 10.1097/SHK.0000000000001446.PMID: 31513049
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Ortega JA, Daley EL, Kour S, Samani M, Tellez L, Smith HS, Hall EA, Esengul YT, Tsai YH, Gendron TF, Donnelly CJ, Siddique T, Savas JN, Pandey UB, Kiskinis E.Neuron. 2020 Apr 8;106(1):90-107.e13. doi: 10.1016/j.neuron.2020.01.020. Epub 2020 Feb 13.PMID: 32059759
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome. García-Cazorla À, Verdura E, Juliá-Palacios N, Anderson EN, Goicoechea L, Planas-Serra L, Tsogtbaatar E, Dsouza NR, Schlüter A, Urreizti R, Tarnowski JM, Gavrilova RH; SHMT2 Working Group, Ruiz M, Rodríguez-Palmero A, Fourcade S, Cogné B, Besnard T, Vincent M, Bézieau S, Folmes CD, Zimmermann MT, Klee EW, Pandey UB, Artuch R, Cousin MA, Pujol A.Acta Neuropathol. 2020 Dec;140(6):971-975. doi: 10.1007/s00401-020-02223-w. Epub 2020 Oct 5.PMID: 33015733 Free PMC article. No abstract available.
Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Gogia N, Sarkar A, Mehta AS, Ramesh N, Deshpande P, Kango-Singh M, Pandey UB, Singh A.Neurobiol Dis. 2020 Jul;140:104837. doi: 10.1016/j.nbd.2020.104837. Epub 2020 Mar 19.PMID: 32199908 Free article.
Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism. Chivet M, Marchioretti C, Pirazzini M, Piol D, Scaramuzzino C, Polanco MJ, Romanello V, Zuccaro E, Parodi S, D'Antonio M, Rinaldi C, Sambataro F, Pegoraro E, Soraru G, Pandey UB, Sandri M, Basso M, Pennuto M.Cells. 2020 Jan 30;9(2):325. doi: 10.3390/cells9020325.PMID: 32019272 Free PMC article.
Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives. Pennuto M, Pandey UB, Polanco MJ.Front Neuroendocrinol. 2020 Apr;57:100821. doi: 10.1016/j.yfrne.2020.100821. Epub 2020 Jan 30.PMID: 32006533 Review.
RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Ramesh N, Kour S, Anderson EN, Rajasundaram D, Pandey UB.Acta Neuropathol Commun. 2020 Aug 18;8(1):138. doi: 10.1186/s40478-020-01021-5.PMID: 32811564 Free PMC article.
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Otte CG, Fortuna TR, Mann JR, Gleixner AM, Ramesh N, Pyles NJ, Pandey UB, Donnelly CJ.Neurobiol Dis. 2020 Dec;146:105078. doi: 10.1016/j.nbd.2020.105078. Epub 2020 Sep 12.PMID: 32927062 Free article.
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3. Ramesh N, Daley EL, Gleixner AM, Mann JR, Kour S, Mawrie D, Anderson EN, Kofler J, Donnelly CJ, Kiskinis E, Pandey UB.Acta Neuropathol Commun. 2020 Oct 31;8(1):177. doi: 10.1186/s40478-020-01060-y.PMID: 33129345 Free PMC article.
Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis. Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC.Hepatology. 2021 Mar;73(3):1176-1193. doi: 10.1002/hep.31328. Epub 2020 Nov 3.PMID: 32438524
Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, Kagan VE.Redox Biol. 2021 Jan;38:101744. doi: 10.1016/j.redox.2020.101744. Epub 2020 Oct 16.PMID: 33126055 Free PMC article.
Decompressive Cranial Vault Remodeling in Osteosclerotic Robinow Syndrome. Herman PI, Marji FP, Anstadt EE, Dvoracek LA, Goldstein JA, Pollack IF, Losee JE.Cleft Palate Craniofac J. 2021 Jan;58(1):126-130. doi: 10.1177/1055665620946573. Epub 2020 Aug 6.PMID: 32757781