Recent Publications

Featured

Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J. An interaction of the 17q12-21 locus with mold exposure in childhood asthma. Pediatr Allergy Immunol. 2021 Feb;32(2):373-376. Epub 2020 Oct 13. 

Fujiogi M, Camargo CA Jr, Raita Y, Zhu Z, Celedón JC, Mansbach JM, Spergel JM, Hasegawa K. Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study. Pediatr Allergy Immunol. 2021 Feb 8. Online ahead of print. 

Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 Feb 4;57(2):2001224. Print 2021 Feb. 

Han YY, Yan Q, Chen W, Forno E, Celedón JC. Serum insulin-like growth factor-1, asthma, and lung function among British adults. Ann Allergy Asthma Immunol. 2021 Mar;126(3):284-291. 

Eddens T, Wolfe R, Nowalk A, Forno E, Campfield BT. The association of trimethoprim-sulfamethoxazole with improved lung function in pediatric asthma. Ann Allergy Asthma Immunol. 2021 Jan 17:S1081-1206(21)00021-1 

2020

Raita Y, Camargo CA Jr, Bochkov YA, Celedón JC, Gern JE, Mansbach JM, Rhee EP, Freishtat RJ, Hasegawa K. Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma. J Allergy Clin Immunol. 2020 Nov 13:S0091-6749(20)31585-2. Online ahead of print. 

Forno E. A Potential New Treatment Option for Asthma in the Setting of Obesity or Insulin Resistance? Am J Respir Crit Care Med. 2020 Nov 19. 

Thakur N, Lovinsky-Desir S, Bime C, Wisnivesky JP, Celedón JC. The Structural and Social Determinants of the Racial/Ethnic Disparities in the U.S. COVID-19 Pandemic. What's Our Role? Am J Respir Crit Care Med. 2020 Oct 1;202(7):943-949.  

Stevens EL, Han YY, Rosser F, Forno E, Acosta-Pérez E, Miller GE, Canino G, Celedón JC. Maternal Depressive Symptoms, Lung Function, and Severe Asthma Exacerbations in Puerto Rican Children. J Allergy Clin Immunol Pract. 2020 Oct 28:S2213-2198(20)31134-X. Online ahead of print. 

Yan Q, Forno E, Herrera-Luis E, Pino-Yanes M, Qi C, Rios R, Han YY, Kim S, Oh S, Acosta-Pérez E, Zhang R, Hu D, Eng C, Huntsman S, Avila L, Boutaoui N, Cloutier MM, Soto-Quiros ME, Xu CJ, Weiss ST, Lasky-Su J, Kiedrowski MR, Figueiredo C, Bomberger J, Barreto ML, Canino G, Chen W, Koppelman GH, Burchard EG, Celedón JC. A genome-wide association study of severe asthma exacerbations in Latino children and adolescents. Eur Respir J. 2020 Oct 22:2002693. Online ahead of print. 

Rosser F, Han YY, Forno E, Acosta-Pérez E, Canino G, Celedón JC. Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico. Ann Allergy Asthma Immunol. 2020 Dec;125(6):658-664.e2.  

Han YY, Yan Q, Yang G, Chen W, Forno E, Celedon JC. Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults. Thorax. 2020 Oct;75(10):849-854.  

Manni ML, Alcorn JF. Calprotectin-g the Lung during Type 2 Allergic Airway Inflammation. Am J Respir Cell Mol Biol. 2019 Oct;61(4):405-407.  

Gopal R, Marinelli MA, Alcorn JF. Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection. Front Immunol. 2020 Oct 22;11:570681. eCollection 2020. 

Cipolla EM, Alcorn JF. Repair of the Lung by Regulatory T Cells. Am J Respir Cell Mol Biol. 2020 Oct;63(4):405-407.  

Landeo-Gutierrez J, Celedón JC. Chronic stress and asthma in adolescents. Ann Allergy Asthma Immunol. 2020 Oct;125(4):393-398.  

Yan Q, Forno E, Herrera-Luis E, Pino-Yanes M, Yang G, Oh S, Acosta-Pérez E, Hu D, Eng C, Huntsman S, Rodriguez-Santana JR, Cloutier MM, Canino G, Burchard EG, Chen W, Celedón JC. A genome-wide association study of asthma hospitalizations in adults. J Allergy Clin Immunol. 2020 Sep 2:S0091-6749(20)31224-0. Online ahead of print. 

Landeo-Gutierrez J, Han YY, Forno E, Rosser FJ, Acosta-Pérez E, Canino G, Celedón JC. Risk factors for atopic and nonatopic asthma in Puerto Rican children. Pediatr Pulmonol. 2020 Sep;55(9):2246-2253.  

Rich HE, Antos D, Melton NR, Alcorn JF, Manni ML. Insights Into Type I and III Interferons in Asthma and Exacerbations. Front Immunol. 2020 Sep 25;11:574027. eCollection 2020. 

Jiang Y, Forno E, Han YY, Xu Z, Hu D, Boutaoui N, Eng C, Acosta-Pérez E, Huntsman S, Colón-Semidey A, Keys KL, Rodríguez-Santana JR, Alvarez M, Pino-Yanes M, Canino G, Chen W, Burchard EG, Celedón JC. A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth. Epigenetics. 2020 Aug 31:1-9. Online ahead of print. 

Forno E, Bacharier LB, Phipatanakul W, Guilbert TW, Cabana MD, Ross K, Covar R, Gern JE, Rosser FJ, Blatter J, Durrani S, Han YY, Wisniewski SR, Celedón JC. Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.  JAMA. 2020 Aug 25;324(8):752-760. 

Stevens EL, Rosser F, Han YY, Forno E, Acosta-Pérez E, Canino G, Celedón JC. Traffic-related Air Pollution, Dust Mite Allergen, and Childhood Asthma in Puerto Ricans. Am J Respir Crit Care Med. 2020 Jul 1;202(1):144-146.  

Thakur N, Lovinsky-Desir S, Bime C, Wisnivesky JP, Celedón JC. Health Equality and Diversity Committee of the American Thoracic Society. The Structural and Social Determinants of the Racial/Ethnic Disparities in the U.S. COVID-19 Pandemic: What's Our Role? Am J Respir Crit Care Med. 2020 Jul 17. Online ahead of print.  

Tobin JM, Nickolich KL, Ramanan K, Pilewski MJ, Lamens KD, Alcorn JF, Robinson KM. Influenza Suppresses Neutrophil Recruitment to the Lung and Exacerbates Secondary Invasive Pulmonary Aspergillosis. J Immunol. 2020 Jul 15;205(2):480-488.  

Alcorn JF, Avula R, Chakka AB, Schwarzmann WE, Nowalk MP, Lin CJ, Ortiz MA, Horne WT, Chandran UR, Nagg JP, Zimmerman RK, Cole KS, Moehling KK, Martin JM. Differential gene expression in peripheral blood mononuclear cells from children immunized with inactivated influenza vaccine. Hum Vaccin Immunother. 2020 Aug 2;16(8):1782-1790 

Alcorn JF. IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection. Front Immunol. 2020 Jun 9;11:1160. eCollection 2020. 

Tobin JM, Nickolich KL, Ramanan K, Pilewski MJ, Lamens KD, Alcorn JF, Robinson KM. Influenza Suppresses Neutrophil Recruitment to the Lung and Exacerbates Secondary Invasive Pulmonary Aspergillosis. J Immunol. 2020 Jul 15;205(2):480-488.  

Cipolla EM, Huckestein BR, Alcorn JF. Influenza sequelae: from immune modulation to persistent alveolitis. Clin Sci (Lond). 2020 Jul 17;134(13):1697-1714. 

Landeo-Gutierrez J, Han YY, Forno E, Rosser FJ, Acosta-Pérez E, Canino G, Celedón JC. Risk factors for  atopic and nonatopic asthma in Puerto Rican children. Pediatr Pulmonol. 2020 Jun 27. Online ahead of print.  

Yang G, Han YY, Forno E, Yan Q, Rosser F, Chen W, Celedón JC. Glycated Hemoglobin A1c, Lung Function, and Hospitalizations Among Adults with Asthma. J Allergy Clin Immunol Pract. 2020 Jun 20:S2213-2198(20)30616-4.  

Kim S, Forno E, Zhang R, Park HJ, Xu Z, Yan Q, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. Expression quantitative trait methylation analysis reveals methylomic associations with gene expression in childhood asthma. Chest. 2020 Jun 19:S0012-3692(20)31716-5.  

Stevens EL, Rosser F, Han YY, Forno E, Acosta-Pérez E, Canino G, Celedón JC. Traffic-related Air Pollution, Dust Mite Allergen, and Childhood Asthma in Puerto Ricans. Am J Respir Crit Care Med. 2020 Jul 1;202(1):144-146.  

Landeo-Gutierrez J, Marsland AL, Acosta-Pérez E, Canino G, Celedón JC. Exposure to violence, chronic stress, asthma, and bronchodilator response in Puerto Rican children. Ann Allergy Asthma Immunol. 2020 Jun;124(6):626-627.e1.  

Forno E, Zhang R, Jiang Y, Kim S, Yan Q, Ren Z, Han YY, Boutaoui N, Rosser F, Weeks DE, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Canino G, Chen W, Celedón JC. Transcriptome-wide and differential expression network analyses of childhood asthma in nasal epithelium. J Allergy Clin Immunol. 2020 Feb 20:S0091-6749(20)30197-4. Online ahead of print.  

Han YY, Forno E, Rosser F, Celedón JC. Serum folate metabolites, asthma, and lung function in a nationwide US study. J Allergy Clin Immunol. 2020 Jul;146(1):220-222.e8.  

Kim S, Forno E, Yan Q, Jiang Y, Zhang R, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium. Eur Respir J. 2020 Apr 3;55(4):1902079.  

Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Shapiro SD, Kolls JK, Campfield BT. FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2020 Apr 15;201(8):934-945. 

Han YY, Rosser F, Forno E, Celedón JC. Electronic vapor products, marijuana use, smoking, and asthma in US adolescents. J Allergy Clin Immunol. 2020 Mar;145(3):1025-1028.e6. 

Rosser F, Forno E, Kurland KS, Han YY, Mair C, Acosta-Pérez E, Canino G, Celedón JC. Annual SO2 exposure, asthma, atopy, and lung function in Puerto Rican children. Pediatr Pulmonol. 2020 Feb;55(2):330-337.  

Landeo-Gutierrez J, Forno E, Miller GE, Celedón JC. Exposure to Violence, Psychosocial Stress, and Asthma. Am J Respir Crit Care Med. 2020 Apr 15;201(8):917-922.  

Han YY, Jerschow E, Forno E, Hua S, Mossavar-Rahmani Y, Perreira KM, Sotres-Alvarez D, Afshar M, Punjabi NM, Thyagarajan B, Shivappa N, Hébert JR, Kaplan RC, Celedón JC. Dietary Patterns, Asthma, and Lung Function in the Hispanic Community Health Study/Study of Latinos. Ann Am Thorac Soc. 2020 Mar;17(3):293-301.  

Han YY, Forno E, Celedón JC. Sex Steroid Hormones and Asthma in a Nationwide Study of U.S. Adults. Am J Respir Crit Care Med. 2020 Jan 15;201(2):158-166. 

Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B, Severe asthma during childhood and adolescence: A longitudinal study.  Journal of Allergy and Clinical Immunology.  2020 Jan;145(1):140-146.e9 

2019

Yang G, Han YY, Sun T, Li L, Rosser F, Forno E, Patel SR, Chen W, Celedón JC. Sleep Duration, Current Asthma, and Lung Function in a Nationwide Study of U.S. Adults. Am J Respir Crit Care Med. 2019 Oct 1;200(7):926-929.  

Boutaoui N, Puranik S, Zhang R, Wang T, Hui DH, Brehm J, Forno E, Chen W, Celedón JC. Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells. Epigenetics. 2019 Sep;14(9):844-849.  

Mendy A, Gopal R, Alcorn JF, Forno E. Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin. Respirology. 2019 Jul;24(7):646-651. 

Yan Q, Liu N, Forno E, Canino G, Celedón JC, Chen W. An integrative association method for omics data based on a modified Fisher's method with application to childhood asthma. PLoS Genet. 2019 May 7;15(5):e1008142. eCollection 2019 May. 

Stevens EL, Rosser F, Forno E, Peden D, Celedón JC. Can the effects of outdoor air pollution on asthma be mitigated? J Allergy Clin Immunol. 2019 Jun;143(6):2016-2018.e1.  

Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG .  Racial Disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program.  Journal of Allergy and Clinical Immunology. 2019 June;143 (6):2052-61. 

Forno E, Celedón JC. Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet? Front Pediatr. 2019 Apr 2;7:115. eCollection 2019.  

Gopal R, Mendy A, Marinelli MA, Richwalls LJ, Seger PJ, Patel S, McHugh KJ, Rich HE, Grousd JA, Forno E, Alcorn JF. Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection. Viruses. 2019 Jun 1;11(6):505.  

Abood RN, McHugh KJ, Rich HE, Ortiz MA, Tobin JM, Ramanan K, Robinson KM, Bomberger JM, Kolls JK, Manni ML, Pociask DA, Alcorn JF. IL-22-binding protein exacerbates influenza, bacterial super-infection. Mucosal Immunol. 2019 Sep;12(5):1231-1243.  

Rich HE, McCourt CC, Zheng WQ, McHugh KJ, Robinson KM, Wang J, Alcorn JF. Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection. Infect Immun. 2019 Apr 23;87(5):e00114-19.  

Jiang Y, Gruzieva O, Wang T, Forno E, Boutaoui N, Sun T, Merid SK, Acosta-Pérez E, Kull I, Canino G, Antó JM, Bousquet J, Melén E, Chen W, Celedón JC. Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents. Eur Respir J. 2019 May 18;53(5):1900102.  

Han YY, Forno E, Celedón JC. Health risk behaviors, violence exposure, and current asthma among adolescents in the United States. Pediatr Pulmonol. 2019 Mar;54(3):237-244.  

Forno E, Wang T, Qi C, Yan Q, Xu CJ, Boutaoui N, Han YY, Weeks DE, Jiang Y, Rosser F, Vonk JM, Brouwer S, Acosta-Perez E, Colón-Semidey A, Alvarez M, Canino G, Koppelman GH, Chen W, Celedón JC. DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study. Lancet Respir Med. 2019 Apr;7(4):336-346. PMID: 30584054 

Han YY, Forno E, Celedón JC. Anxiety and noneosinophilic asthma among adults in the United States. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1367-1369.e1.  

2018

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Rich HE, and JF Alcorn. Novel protective mechanism for interleukin – 33 at the mucosal barrier during influenza-associacted bacterial superinfection. Mucosal Immunol 11(1):199-208, 2018. 

Szentpetery SE, Han YY, Brehm JM, Acosta-Pérez E, Forno E, Boutaoui N, Canino G, Alcorn JF, Celedón JC. Vitamin D insufficiency, plasma cytokines, and severe asthma exacerbations in school-aged children. J Allergy Clin Immunol Pract 6(1):289-291, 2018.  

Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES. Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice. Biochem Biophys Res Commun 497(2):700-704, 2018.  

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, and JF Alcorn. The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice. JCI Insight. 2018 Apr 5;3(7). pii: 97470.  

Gopal R, Lee B, McHugh KJ, Rich HE, Ramanan K, Mandalapu S, Clay ME, Seger PJ, Enelow RI, Manni ML, Robinson KM, Rangel-Moreno J, Alcorn JF. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018 Sep 25;9:2151. eCollection 2018. 

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, and JK Kolls. Murine models of Pneumocystis infection recapitulate human primary immune disorders. JCI Insight. 2018 Jun 21;3(12). pii: 91894.  

Rich HE and JF Alcorn. IL-17 Strikes a Chord in Chronic Obstructive Pulmonary Disease Exacerbation. Am J Respir Cell Mol Biol 58(6):669-670, 2018.  

Rosser F, Han YY, Forno E, Celedón JC. Urinary polycyclic aromatic hydrocarbons and allergic sensitization in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2018 Nov;142(5):1641-1643.e6.  

Han YY, Forno E, Boutaoui N, Canino G, Celedón JC. Vitamin D insufficiency, TH2 cytokines, and allergy markers in Puerto Rican children with asthma. Ann Allergy Asthma Immunol. 2018 Oct;121(4):497-498.e1.  

Han YY, Forno E, Shivappa N, Wirth MD, Hébert JR, Celedón JC. The Dietary Inflammatory Index and Current Wheeze Among Children and Adults in the United States. J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):834-841.e2.