Udai Pandey laboratory is interested in understanding the molecular basis of amyotrophic lateral sclerosis (ALS) and other related motor neuron degeneration diseases so that effective therapies can be developed.
Recently, mutations in RNA-binding proteins have been identified in both sporadic and familial forms of ALS. Disease-causing mutations in these RNA-binding proteins indicate that defects in RNA metabolism might play an important role in causing motor neuron degeneration in ALS.
Dr. Pandey’s laboratory has developed drosophila models of ALS that recapitulate several key pathological features of human disease such as neurodegeneration and behavioral defects. Dr. Pandey’s lab has been utilizing biochemical, cell biological, and genetic tools to dissect molecular mechanisms of ALS in drosophila and mammalian neuronal models.