Recent Publications

Feranchak AP, Orenstein SR, Cohn JF. Behaviors associated with onset of gastroesophageal reflux episodes in infants. Clinical Pediatrics. 1994; 33:654-662

MacPhee M, Hoffenberg E, Feranchak AP. Quality of life factors in adolescent inflammatory bowel disease. J Inflamm Bowel Dis. 1997; 4(1): 6-11.

Roman RM, Wang Y, Lidofsky SD, Feranchak AP, Lomri N, Scharschmidt BF, and JG Fitz. Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J. Biol. Chem. 1997; 272:21970-21976.

Feranchak AP, Roman RM, Schwiebert EM, Fitz JG.  Phosphatidylinositol 3-kinase contributes to cell volume regulation through effects on ATP release.  J. Biol. Chem. 1998; 273 (24): 14906-14911.

Feranchak AP, Tyson RW, Narkewicz MR, Karrer FM, Sokol RJ.  Fulminant Epstein-Barr viral hepatitis: Orthotopic liver transplantation and review of the literature.  Liver Transplantation and Surg. 1998; 4 (6):469-476.

Feranchak AP, Sontag MK, Wagener JS, Hammond KB, Accurso FJ, Sokol RJ.  Prospective long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen.  J Pediatr 1999; 135:601-10.

Roman RM, Feranchak AP, Salter KD, Fitz JG.  Endogenous ATP release regulates Cl- secretion in cultured human and biliary epithelial cells.  Am J Physiol 1999; 276: G1391-400.

Roman RM, Feranchak AP, Davison AK, Schwiebert EM, Fitz JG.  Evidence for Gd (3+) inhibition of membrane ATP permeability and purinergic signaling.  Am J Physiol 1999; 277: G1222-30.

Feranchak AP, Roman RM, Salter KD, Toker A, Fitz JG.  The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport.  J. Biol. Chem. 1999; 274:30979-30986.

Schlenker T, Feranchak AP, Schwake L, Stremmel W, Roman R, Fitz JG.  Functional interactions between oxidative stress, membrane Na+ permeability, and cell volume in rat hepatoma cells.  Gastroenterol 2000; 118:395-403.

Feranchak AP, Fitz JG, Roman RM.  Volume-sensitive signaling in human hepatocytes.  J Hepatol 2000; 33:174-82. 

featured in editorial: Dranoff JA, Nathanson MH.  It’s swell to have ATP in the liver.  J Hepatol 2000; 33:323-325.

Fouassier L, Duan C, Feranchak AP, Yun CH, Sutherland E, Simon F, Fitz JG, Doctor RB.  Ezrin-radixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia.  Hepatology 2001; 33:166-76.

Roman RM, Smith RL, Feranchak AP, Clayton GH, Doctor RB, Fitz JG.  ClC-2 chloride channels contribute to HTC cell volume homeostasis.  Am J Physiol Gastrointest Liver Physiol.  2001; 280: G344-G353.

Roman RM, Lomri N, Braunstein G, Feranchak AP, Simeoni LA, Davison AK, Mechetner E, Schwiebert EM, Fitz JG.  Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.  J Membr Biol 2001; 183:165-73.

Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG.  P38 MAP Kinase modulates liver cell volume through inhibition of membrane Na+ permeability.  J Clin Invest. 2001; 108:1495-1504.

Roman RM, Feranchak AP, Troetsch M, Dunkelberg JC, Kilic G, Schlenker T, Schaack J, Fitz JG.  Molecular characterization of volume-sensitive SK (Ca) channels in human liver cell lines.  Am J Physiol Gastrointest Liver Physiol 2002; 282: G116-22.

Feranchak AP, Kilic G, Wojtaszek PA, Qadri I, Fitz JG.  Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability.  J Biol Chem. 2003; 278(45):44632-8.

Feranchak AP, Doctor RB, Troetsch M, Brookman K, Johnson SM, Fitz JG.  Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels.  Gastroenterol, 2004; 127:903-13.

Doctor RB, Matzakos T, McWilliams R, Johnson S, Feranchak AP, Fitz JG.  Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors.  Am J Physiol Gastrointest Liver Physiol 2005; 288: G779-

Feranchak AP, Gralla J, King R, Ramirez R, Corkill M, Narkewicz M, Sokol RJ.  Comparison of Indices of Vitamin A status in children with chronic liver disease.  Hepatology 2005; 42:782-792.

featured in Hepatology Highlights, Elwyn Elias, editor, Hepatology 2005; 42: 1242.

Emmett DS, Feranchak AP, Puljak L, Miller B, McWilliams R, Doctor RB, Fitz JG.  Characterization of a novel population of P2X4 receptors in hepatocytes.    Hepatology 2008; 47:698-705.

Stallings VA, Stark LJ, Robinson KA, Feranchak AP, Quinton H.  Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systemic review.  J Am Diet Assoc 2008; 108:832-9.

Woo K, Dutta A, Patel V, Kresge C, Feranchak AP.  Fluid-flow induces mechanosensitive ATP release, calcium signaling, and Cl- transport in biliary epithelial cells through a PKCz-dependent mechanism. J Physiol 2008; 586 (11):2779-2798.

featured in Perspectives, editorial by Praetorius HA & Leipziger J.  J Physiol 2008; 586(11):2669.

featured in Highlights from the Literature, nominated by Hugh Matthews, Assoc Editor Journal of Physiology.  Physiology 2008; 23:185.

Dutta AK, Woo K, Doctor RB, Fitz JG, Feranchak AP.  Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor mediated IP3 and Ca2+ release.  Am J Physiol Gastrointest Liver Physiol 2008; 295: G1004-G1015.

Simpson LS, Burdine L, Dutta AK, Feranchak AP, Kodadek T.  Selective toxin sequestrants for the treatment of bacterial infections.  J Am Chem Soc 2009; 131(16):5760-2.

Dutta AK, Khimji AK, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP.  Identification and functional characterization of the intermediate conductance Ca2+-activated K+ channel (IK-1) in biliary epithelium.  Am J Physiol Gastrointest Liver Physiol 2009; 297: G1009-G1018.

Feranchak AP, Lewis MA, Kresge C, Sathe M, Bugde A, Luby-Phelps K, Antich P, Fitz JG.  Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium.  J Biol Chem 2010; 285:8138-47. 

Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser S, Alpini G, Feranchak AP.  ATP release and P2 receptor-mediated secretion in small and large mouse cholangiocytes. Hepatology 2010; 52:1819-1828.

Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.  J Biol Chem 2011; 286:766-776.

Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP.  Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles. J Biol Chem 2011; 286:25363-76.

Mendoza JL, Schmidt A, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ.  Requirements for efficient correction of DF508 CFTR revealed by analyses of evolved sequences.  Cell, 2012; 148:164-74.

Geiser JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C. Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion. Endocrinology 2013; 154(2):675-84.

Dutta AK, Woo K, Khimgi AK, Kresge C, Feranchak AP. Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEME16A. Am J Physiol Gastrointest Liver Physiol 2013; 304(1): G87-98.

Li Q, Kresge C, Bugde A, Lamphere M, Park J, Feranchak AP.  Regulation of mechanosensitive biliary epithelial transport by the epithelial Na+ channel, ENaC.  Hepatology, 2016; 63(2):538-492016.

Dutta AK, Khimji AK, Liu S, Karamysheva Z, Fujita A, Kresge C, Rockey DC, Feranchak AP.  PKCa regulates TMEM16A-mediated Cl- secretion in human biliary cells. Am J Physiol Gastrointest Liver Physiol. 2016; 310(1):  G34-42. 

Li Q, Dutta A, Kresge C, Bugde A, Feranchak AP.  Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A (TMEM16A) Cl- channels.  Hepatology, 2018; 68(1):187-199.

Li Q, Kresge C, Feranchak AP.  The mechanosensory transient receptor potential vanilloid member 4 (TRPV4) regulates mouse cholangiocyte secretion and bile formation. Am J Physiol Gastrointest Liver Physiol 2020; 318 (2):G277-G287

Dutta A, Boggs K, Khimji A, Getachew Y, Wang Y, Kresge C, Rockey D,  Feranchak AP.  Signalling through the interleukin-4 and interleukin-13 receptor complexes regulate cholangiocyte TMEM16A expression and biliary secretion. Am J Physiol Gastrointest Liver Physiol 2020; 318(4):G763-G771.

Feranchak AP, Sokol RJ.  How many wrongs make a right (or a left)? Vertebrate asymmetry unraveled.  J. Pediatr Gastroenterol Nutr. 1999; 28:239-241.

Feranchak AP, Occena-Ramirez R, Sokol RJ.  Medical and Nutritional Management of Cholestasis; In: Suchy FJ, Sokol RJ, Balistreri WF, eds. Liver Disease in Children, Lippincott

Feranchak AP, Fitz JG.  Regulation of Biliary Secretion by Extracellular Nucleotides.  Drug Develop Res 2001; 52:232-238.

Dunkelberg JC, Feranchak AP, Fitz JG.  Liver cell volume regulation: size matters.  Hepatology 2001; 33:1349-52.

Feranchak AP, Sokol RJ.  Cholangiocyte Biology and Cystic Fibrosis Liver Disease. Seminars in Liver Disease 2001; 21: 471-488.

Guest Editor.  Sokol RJ, Feranchak AP.  Genetic and metabolic basis of pediatric liver diseases.  Semin Liver Dis, 2001; 21:469-595.

Feranchak AP, Fitz JG.  Adenosine triphosphate release and purinergic regulation of cholangiocyte transport.  Seminars in Liver Disease 2002; 22:251-262.

Feranchak AP, Fitz JG.  Purinergic Receptors and Hepatobiliary Function. In Schwiebert EM ed, Extracellular Nucleotides and Nucleosides: release, receptors,  and physiological and pathological effects.  Current Topics in Membranes, Academic Press 2003; 54:395-414

Feranchak AP.  Stop the CAR and reduce acetaminophen hepatotoxicity. J Pediatric Gastroenterol and Nutr.  2003; 37:101-2. 

Feranchak AP.  Ion Channels in Digestive Health and Disease. J Pediatr Gastroenterolog Nutr, 2003; 37:230-41.

Feranchak AP, Sokol RJ. Vitamins. In:  Pediatric Nutrition Handbook 5th ed, American Academy of Pediatrics, 2004.

Feranchak AP.  Hepatobiliary Complications of Cystic Fibrosis. Curr Gastroenterology Rep. 2004; 6:231-9.

Brigman C, Feranchak AP, Liver involvement in Cystic Fibrosis.  Curr Treat Options Gastroenterol 2006; 9:484-496.

Feranchak AP, Sokol RJ.  Medical and Nutritional Management of Cholestasis;  In: Suchy FJ, Sokol RJ, Balistreri WF, eds. Liver Disease in Children 3rd ed., Cambridge, 2007; 190-231

Feranchak AP.  Cystic Fibrosis Liver Disease.  In: Suchy FJ, Sokol RJ, Balistreri    WF, eds. Liver Disease in Children, 3rd ed. Cambridge, 2007:572-594.

Feranchak AP.  The Liver in Cystic Fibrosis.  In: Rodes J, Benhamou JP, Blei A, Reichen J, Rizzetto M, eds.  Textbook of Hepatology, 3rd ed.  Blackwell Publishing, 2007;16.4: 1336-1342

Feranchak AP, Fitz JG.  Thinking outside the cell: the role of extracellular ATP in bile formation.  Gastroenterol 2007; 133:1726-8.

Feranchak AP.  Pathophysiology of CF-associated liver disease: lessons from the bench” Pediatr Pulmonol 2007; Suppl 30:136-138.

Feranchak AP.  Vitamins. In:  Pediatric Nutrition Handbook 6th ed, American Academy of Pediatrics, 2009.

Sathe M, Feranchak AP.  Liver disease.  In: Allen, Rubenstein, Panitch, eds. Cystic Fibrosis: Lung Biology in Health and Disease, Volume 242.  Informa Health Care, 2010; 285-

Feranchak AP.  Introducing the AASLD President: J. Gregory Fitz.  Hepatology, 2013.

Feranchak AP.  Vitamins. In:  Pediatric Nutrition Handbook  7th ed, American Academy of Pediatrics, 2013.

Sathe M, Feranchak AP. Cystic Fibrosis Liver Disease.  In: Suchy FJ, Sokol RJ, Balistreri WF, eds. Liver Disease in Children, 4th ed. Cambridge University Press, 2014; 419-434

Feranchak AP, Suchy FJ, Sokol RJ. Medical and Nutritional Management of Cholestasis; In: Suchy FJ, Sokol RJ, Balistreri WF, eds. Liver Disease in Children 4th ed., Cambridge, 2014; 111-139.

Feranchak AP. Bile secretion and cholestasis. In: Podolsky DK, ed. Yamada’s textbook of Gastroenterology, 6th ed. Wiley-Blackwell, 2016.

Feranchak AP.  Cystic Fibrosis Transmembrane Conductance Regulator: Actin (g) as a Master Regulator of Cholangiocyte Function. Hepatology, 2018, 67(3):833-836.

Sathe M, Feranchak AP.  Vitamins. In:  Pediatric Nutrition Handbook 8th ed, American Academy of Pediatrics, 2019

Lazar L, Sathe M, Feranchak AP. Cystic Fibrosis Liver Disease.  In: Suchy FJ, Sokol RJ, Balistreri WF, eds. Liver Disease in Children, 5th ed. Cambridge University Press, 2020.

Squires J, Feranchak AP. Bile secretion and cholestasis. In: Podolsky DK, ed. Yamada’s textbook of Gastroenterology, 7th ed. Wiley-Blackwell, 2020.