The Dermody Lab studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but the disease is restricted to the very young. Chikungunya virus (CHIKV) is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. To learn more about ongoing and new CHIKV projects, please contact the Silva Lab.
Research in the Dermody Lab encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.
Affiliated Faculty and Staff
- Terence S. Dermody, MD - Principal Investigator
- Pamela H. Brigleb, BS - Graduate Student
- Kay Lynn Fiske, BS - Research Technician II
- Kira A. Griswold, BS - Graduate Student
- Adaeze O. Izuogu, PhD - Postdoctoral Fellow
- Christopher H. Lee, BS - Graduate Student
- Alexa N. Roth, PhD - Postdoctoral Fellow
- Pengcheng Shang, PhD - Postdoctoral Fellow
- Xayathed Somoulay, BS - Graduate Student
- Danica M. Sutherland, PhD - Research Instructor and Laboratory Manager
- Gwen M. Taylor, PhD - Research Instructor
- Olivia L. Welsh, BS - Research Technician II
Our Research Interests
We aim to determine the role of each step in the reovirus infectious cycle in the pathogenesis of reovirus-induced disease.
The Vira I. Heinz Chair and Affiliates Symposium
This event (by invitation only) will be hosted in August, 2022.