Recent Publications


Recent publication by Melissa J. Anslow, MD revealing that microRNAs in developing urinary tract stroma prevent vesicoureteral reflux in mice. Editorial featured article.  Read more at UPMC Physician Resources.

Anslow MJ, Bodnar AJ, Cerqueira DM, Bushnell D, Shrom BE, Sims-Lucas S, Bates CM and Ho J. Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma. Pediatr Res, 88:382-390, 2020. PMID: 32015493, PMCID: PMC7396288

Recent publication by Paul K. Fadakar, MD (middle author) examining the role of T follicular helper cells in antibody mediated rejection.

Louis K, Macedo C, Bailly E, et al. Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation. J Am Soc Nephrol, 31(10): 2457-2474, 2020. PMID: 32723838, PMCID: PMC7608995

Recent publication by Michael L. Moritz, MD reporting findings from a survey of pediatric hospitalists across the country to determine if they were following practice guidelines from the American Academy of Pediatrics on the use of isotonic maintenance fluid in hospitalized children.

Hall AM, Ayus JC, Moritz ML. How Salty Are Your Fluids? Pediatric Maintenance IV Fluid Prescribing Practices Among Hospitalists. Front Pediatr. 15(7):549, 2020; 7: 549. PMID: 32010650, PMCID: PMC6974532

Recent publication by Carlton M. Bates, MD showing that fibroblast growth factor receptor 2 signaling in bladder urothelium prevents aberrant regenerative responses to cyclophosphamide injury. 

Narla ST, Bushnell DS, Schaefer CM, Nouraie M, Tometich JT, Hand TW,  Bates CM. Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after Cyclophosphamide injury. Am J Pathol, 2020, in press. PMCID-pending.

Other Publications


Airik M, Schüler M, McCourt B, Weiss AC, Herdman N, Lüdtke TH, Widmeier E, Stolz DB, Nejak-Bowen KN, Yimlamai D, Wu YL, Kispert A, Airik R, Hildebrandt F. Loss of Anks6 leads to YAP deficiency and liver abnormalities. Hum Mol Genet. 2020 Nov 4;29(18):3064-3080. 

Anslow MJ, Bodnar AJ, Cerqueira DM, Bushnell D, Shrom BE, Sims-Lucas S, Bates CM and Ho J. Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma. Pediatr Res, 88:382-390, 2020. PMID: 32015493, PMCID: PMC7396288

Ayus JC, Fuentes N, Go AS, Achinger SG, Moritz ML, Nigwekar SU, et al. Chronicity of Uncorrected Hyponatremia and Clinical Outcomes in Older Patients Undergoing Hip Fracture Repair. Front Med 2020;7. 

Bataineh A, Dealmeida D, Bilderback A, Ambrosino R, Al-Jaghbeer MJ, Fuhrman DY, , Kellum JA. Sustained effects of a clinical decision support system for acute kidney injury. Nephrol Dial Transplant 2020;35(10):1819-1821. 

Cargill KR, Chiba T, Murali A, Mukherjee E, Crinzi E, Sims-Lucas S. Prenatal hypoxia increases susceptibility to kidney injury. PLoS ONE 2020;15(2). 

Formeck CL, Joyce EL, Fuhrman DY, Kellum JA. Association of acute kidney injury with subsequent sepsis in critically ill children. Pediatr Crit Care Med. 2020 Aug 27(Online ahead of print). PMID: 32858738. 

Fuhrman DY, Nguyen L, Joyce E, Kellum JA. Outcomes of young adults with congenital heart disease that experience AKI in the ICU. Cardiol Young. 2020 (In press)

Fuhrman DY, Kellum JA, Joyce EL, Miyashita Y, Mazariegos GV, Ganoza A, et al. The use of urinary biomarkers to predict acute kidney injury in children after liver transplant. Pediatr Transplant 2020;24(1). 

Goetzman ES, Bharathi SS, Zhang Y, Zhao X-, Dobrowolski SF, Peasley K, Sims-Lucas S, Monga SP Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice. Sci Rep 2020;10(1). 

Hall AM, Ayus JC, Moritz ML. How Salty Are Your Fluids? Pediatric Maintenance IV Fluid Prescribing Practices Among Hospitalists. Front Pediatr 2020;7. 

Hanevold CD, Miyashita Y, Faino AV, Flynn JT. Changes in ambulatory blood pressure phenotype over time in children and adolescents with elevated blood pressures. J Pediat. 2020 Jan; 126:31-43.e2 

Hemker SL, Cerqueira DM, Bodnar AJ, Cargill KR, Clugston A, Anslow MJ, et al. Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number. FASEB J 2020;34(4):5782-5799. 

Hurley E, Peeples ES, Bates CM, Hunstad DA, Barkin SL. Perspective commentary from the Society for Pediatric Research: supporting early-stage pediatric physician–scientist success. Pediatr Res 2020;87(5):834-838. 

Louis K, Macedo C, Bailly E, Lau L, Ramaswami B, Marrari M, Landsittel D, Chang A, Chandran U, Fadakar P, Yamada M, Chalasani G, Randhawa P, Zeevi A, Singh H, Lefaucheur C, Metes D. Coordinated circulating T follicular helper and activated B cell responses underlie the onset of antibody-mediated rejection in kidney transplantation. J Am Soc Nephrol 2020;31(10):2457-2474. 

Manrique-Caballero CL, Peerapornratana S, Formeck C, Del Rio-Pertuz G, Gomez Danies H, Kellum JA. Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill. Crit Care Clin. 2020 Apr;36(2):333-356.  

Narla ST, Bushnell DS, Schaefer CM, Nouraie M, Bates CM. Keratinocyte Growth Factor Reduces Injury and Leads to Early Recovery from Cyclophosphamide Bladder Injury. Am J Pathol 2020;190(1):108-124 

Ozbaki-Yagan N, Liu X, Bodnar AJ, Ho J, Butterworth MB. Aldosterone-induced microRNAs act as feedback regulators of mineralocorticoid receptor signaling in kidney epithelia. FASEB J 2020;34(9):11714-11728. 

Shaikh N, Rajakumar V, Peterson CG, Gorski J, Ivanova A, Gravens Muller L, et al. Cost-Utility of Antimicrobial Prophylaxis for Treatment of Children With Vesicoureteral Reflux. Front Pediatr 2020;7. 

Taylor MD, Allada V, Moritz ML, Nowalk AJ, Sindhi R, Aneja RK, et al. Use of C-reactive protein and ferritin biomarkers in daily pediatric practice. Pediatr Rev 2020;41(4):172-183. 


Airik R, Airik M, Schueler M, Bates CM, Hildebrandt F. Roscovitine blocks collecting duct cyst growth in Cep164-deficient kidneys. Kidney Int. 2019 Aug;96(2):320-326.

Ayus JC, Moritz ML. Misconceptions and Barriers to the Use of Hypertonic Saline to Treat Hyponatremic Encephalopathy. Front Med (Lausanne). 2019 Mar 15;6:47

Canetta PA, CureGN Consortium (Swiatecka-Urban A). Health relater quality of life in glomerular disease. Kidney Int. 2019 May;95(5):1209-1224. doi: 10.1016/j.kint.2018.12.018.
Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, GoetzmanES, Sims-Lucas S. Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019; 3

Carpenter SL, Goldman J, Sherman AK, Selewski DT, Kallash M, Tran CL, Seamon M, Katsoufis C, Ashoor I, Hernandez J, Supe-Markovina K, D'alessandri-Silva C, DeJesus-Gonzalez N, Vasylyeva TL, Formeck C, Woll C, Gbadegesin R, Geier P, Devarajan P, Smoyer WE, Kerlin BA, Rheault MN. Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome. Pediatr Nephrol. 2019 Feb;34(2):261-267. doi: 10.1007/s00467-018-4072-6. Epub 2018 Sep 7. PubMed PMID: 30194664; PubMed Central PMCID: P

Cerqueira DM, Hemker SL, Bodnar AJ, Ortiz DM, Oladipupo FO, Mukherjee E, Gong Z, Appolonia C, Muzumdar RH, Sims-Lucas S and Ho J. In utero exposure to maternal diabetes impairs nephron progenitor differentiation. Am J Physiol Renal Physiol, 2019 Nov 1;317(5):F1318-F1330. PMID: 31509011.

Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S. Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. J Am Soc Nephrol. 2019 Dec;30(12):2384-2398.

Cruz DF, Farinha CM, Swiatecka-Urban A. Unraveling the function of Lemur Tyrosine Kinase 2 Network. Frontiers in Pharmacology. 2019 Jan 29;10:24. doi: 10.3389/fphar.2019.00024. eCollection 201

Espiritu EB, Huajun J, Moreau-Marquis S, Sullivan M, Yan K, Beer Stolz D, Sampson MG, Hukriede NA, Swiatecka-Urban A.  The Human Nephrin Y1139RSL Motif is Essential for Podocyte Foot Process Organization During Glomerular Development. J Biol Chem, 2019 Jul 12;294(28):10773-10788. doi: 10.1074/jbc.RA119.008235

Formeck C, Swiatecka-Urban A. Extra-renal manifestations of hemolytic-uremic syndrome: an educational review. Journal of Pediatric Nephrology. 2019 Aug;34(8):1337-1348. doi:10.1007/s00467-018-4039-7

Francipane MG, Han B, Oxburgh L, Sims-Lucas S, Li Z, Lagasse E. Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates. J Tissue Eng Regen Med. 2019 Sep;13(9):1724-1731.

Fuhrman DY, Kellum JA, Joyce EL, Miyashita Y, Mazariegos GV, Ganoza A, Squires JE. The use of urinary biomarkers to predict acute kidney injury in children after liver transplant. Pediatr Transplant. 2019 Oct 25:e13608.

Fuhrman DY, Nguyen LG, Sanchez-de-Toledo J, Priyanka P, Kellum JA. Postoperative acute kidney injury in young adults with congenital heart disease. Ann Thoracic Surg. 2019 May 107(5):1416-1420. PMID: 30763561.

Fuhrman DY. Defining acute kidney injury: getting back to fundamentals. Pediatr Crit Care Med. 2019 Apr 20(4):381-382. PMID 30950989. 

Fuhrman, DY, Nguyen L, Hindes M, Kellum JA. Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: detecting subclinical kidney injury. Congenit Heart Dis. 2019 Dec [Epub ahead of print]. PMID: 31793232.

Hall AM, Ayus JC, Ayach T, Moritz ML. Not Salty Enough. J Hosp Med. 2019 Aug;14(8):516

Hanevold CD, Miyashita Y, Faino AV, Flynn JT. Changes in ambulatory blood pressure phenotype over time in children and adolescents with elevated blood pressures. J Pediatr. 2019 Nov 1.

Joyce EL, Kane-Gill SL, Priyanka P, Fuhrman DY, Kellum JA. Piperacillin/Tazobactam and antibiotic-associated acute kidney injury in critically ill children. J Am Soc Nephrol. 2019 Sep [Epub ahead of print]. PMID: 31501354.

Joyce, EL, DeAlmeida DR, Fuhrman DY, Priyanka P, Kellum JA. eResearch in acute kidney injury: a primer for electronic health record research. Nephrol Dial Transplant. 2019 Mar 34(3):401-417. PMID: 29617846. 

Kellum JA, Fuhrman DY. The handwriting on the wall: there will be soon be a drug for AKI. Nat Rev Nephrol. 2019 Feb 15(2):65-66. PMID: 30546091. 

Mariani LH, CureGN Consortium (Swiatecka-Urban A). CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease. AJKD 2019 Feb;73(2):218-229. doi: 10.1053/j.ajkd.2018.07.020.

Mitash N. Mu F., Joshua E Donovan JE, Myerburg MM, Ranganathan S, Greene CM, Swiatecka-Urban A. Transforming Growth Factor-β1 selectively recruits microRNAs to the RNA induced silencing complex and degrades CFTR mRNA under permissive conditions in human bronchial epithelial cells. Int. J. Mol. Sci. 2019, 20(19), 4933;

Moritz ML. Clinical Feature: Should Lactated Ringers Become the Default Intravenous Solution? AAP Section of Nephrology Newsletter. Spring 2019

Moritz ML. Syndrome of Inappropriate Antidiuresis. Pediatr Clin N Am 66 (2019) 209–226

Narla ST, Bushnell DS, Schaefer CM, Nouraie M, Bates CM. Keratinocyte Growth Factor reduces injury and leads to early recovery from Cyclophosphamide bladder injury. Am J Pathol. 2019 Oct 22. [Epub ahead of print]

Patel M, Ayus JC, Moritz ML. Fragility fractures and reversible osteopaenia due to chronic hyponatreaemia in an adolescent male.  BMJ Case Rep. 2019 Jul 27;12(7). Pii:e229875

Phua YL, Chen KH, Hemker SL, Marrone AK, Bodnar AJ, Liu X, Clugston A, Kostka D, Butterworth MB and Ho J. Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors. Am J Physiol Renal Physiol, 2019 May 1;316(5):F993-F1005. PMID: 30838872.

Shayota BJ, Le NT, Bekheirnia N, Rosenfeld JA, Goldstein AC, Moritz M, Bartholomew DW, Pastore MT, Xia F, Eng C, Yang Y, Lamb DJ, Scaglia F, Braun MC, Bekheirnia MR. Characterization of the renal phenotype in RMND1-related mitochondrial disease. Mol Genet Genomic Med. 2019 Sep 30:e973

Singbartl K, Formeck CL, Kellum JA. Kidney-Immune System Crosstalk in AKI. Semin Nephrol. 2019 Jan;39(1):96-106. doi: 10.1016/j.semnephrol.2018.10.007. Review. PubMed PMID: 30606411.

Tan RJ, Li Y, Rush BM, Cerqueira DM, Zhou D, Fu H, Ho J, Stolz D and Liu Y. Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP-7. JCI Insight, 2019 Nov 19;. doi: 10.1172/jci.insight.122399. [Epub ahead of print]. PMID: 31743113.

Vasylyeva TL, Diaz-Gonzalez de Ferris ME, Hains DS, Ho J, Harshman LA, Reidy KR, Brady TM, Okamura DM, Samsonov DV, Wenderfer SE, Hartung EA.  Developing a Research Mentorship Program: The American Society of Pediatric Nephrology’s experience. Front Pediatr. 2019 Apr 24;7:155. doi: 10.3389/fped.2019.00155. eCollection 2019. PMID: 31069203.

Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Lüdtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A. Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463.

Widmeier E, Airik M, Hugo H, Schapiro D, Wedel J, Ghosh CC, Nakayama M, Schneider R, Awad AM, Nag A, Cho J, Schueler M, Clarke CF, Airik R, Hildebrandt F. Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice. J Am Soc Nephrol. 2019 Feb 8.