Prochownik Lab

Dr. Ed Prochownik's laboratory is interested in cancers resulting from the deregulated expression of the c-Myc oncoprotein. The lab uses animal models of pediatric and adult liver cancer (hepatoblastoma and hepatocellular carcinoma) to ascertain the molecular, biochemical, and metabolic changes that accompany tumor progression, regression, and recurrence.  

The Prochownik lab is utilizing over-expression and knockout models to determine how genes that cooperate with or are affected by Myc such as ChREBP and pyruvate dehydrogenase specifically contribute to the metabolic and molecular landscapes of these tumors.