The Campfield laboratory studies inflammation and immunity in the lung, partly focused on the role of follistatin-like protein 1 (FSTL-1). Lung infection is the leading cause of childhood mortality worldwide, and new therapies are essential to improving outcomes. We have been focused on host defense mechanisms mediating protection against infection. We had identified that FSTL-1 is a novel gene highly expressed in the lung and important for inflammatory responses and tissue repair; however, the role of FSTL-1 in lung immunity is unknown. The main thrust of our work employs several in vivo and in vitro models of acute inflammation to evaluate mechanisms by which innate immune factors interact with adaptive immune responses in the lung. In turn, the overarching goal lies in understanding how innate immune responses in the lung yield protective responses against infection.
- Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells. Campfield BT, Eddens T, Henkel M, Majewski M, Horne W, Chaly Y, Gaffen SL, Hirsch R, Kolls JK. Immunol Cell Biol. 2017 Sep;95(8):656-665. doi: 10.1038/icb.2017.26. Epub 2017 Apr 5.
- Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation. Chen K, Campfield BT, Wenzel SE, McAleer JP, Kreindler JL, Kurland G, Gopal R, Wang T, Chen W, Eddens T, Quinn KM, Myerburg MM, Horne WT, Lora JM, Albrecht BK, Pilewski JM, Kolls JK. JCI Insight. 2016 Jul 21;1(11). pii: e87168.
- A Novel CD4+ T Cell-Dependent Murine Model of Pneumocystis-driven Asthma-like Pathology. Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK. Am J Respir Crit Care Med. 2016 Oct 1;194(7):807-820.
- Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection. Campfield BT, Nolder CL, Marinov A, Bushnell D, Davis A, Spychala C, Hirsch R, Nowalk AJ. Microb Pathog. 2014 Aug;73:70-9. doi: 10.1016/j.micpath.2014.04.005. Epub 2014 Apr 24.
- Vaccine approaches for multidrug resistant Gram negative infections. Campfield B, Chen K, Kolls JK. Curr Opin Immunol. 2014 Jun;28:84-9. doi: 10.1016/j.coi.2014.02.002. Epub 2014 Mar 15.
Current Lab Members
- Brian T. Campfield, M.D.
- Matt Henkel - Lab Manager, Lead Technician
- Jess Partyka - Lab Technician
- Justin Dutta - graduate student, University of Pittsburgh Grad. School of Public Health
- Andrew Tout - medical student, University of Pittsburgh School of Medicine
Opportunities in the Campfield Lab
We welcome the opportunity to develop our research program through the addition of talented students and trainees. If you are interested in becoming a contributing team member, please contact us.