The Dermody laboratory studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but the disease is restricted to the very young. Chikungunya virus (CHIKV) is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. To learn more about ongoing and new CHIKV projects, please contact the Silva Lab.
Research in the Dermody laboratory encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.
- Terence S. Dermody, M.D. - Chair, Department of Pediatrics
- Pavithra Aravamudhan, Ph.D. - Post-doctoral Fellow
- Pam Brigleb - Graduate Student
- Adaeze Izuogu, Ph.D. - Post-doctoral Fellow
- Chris Lee - Graduate Student
- Anthony Lentscher - Graduate Student
- Nicole McAllister - Graduate Student
- Krishnan Raghunathan, Ph.D. - Research Assistant Professor
- Pengcheng Shang, Ph.D. - Post-doctoral Fellow
- Danica Sutherland, Ph.D. - Research Instructor and Laboratory Manager
- Gwen Taylor, Ph.D. - Research Instructor
- Kelly Urbanek, M.S. - Research Assistant IV