Recent Publications


Bates CM, Ho J, Cerqueira DM and Pawan P. Nephrology and Fluid/Electrolyte Physiology: Neonatalogy Questions and Controversies (edited by W. Oh, S. Baumgart and M Baum). 3rd Ed. Elsevier Saunders; Chapter 8: Renal Development and Molecular Pathogenesis of Renal Dysplasia, 2018.

De Santi C, Gadi S, Swiatecka-Urban A, Greene C. identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3’UTR. AIMS Genetics. 2018; 5 (1): 53-62.

Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, and Pazour GJ. Ift25 IS Not a Cystic Kidney Disease Gene but is Required for Early Steps of Kidney Development. Mech Dev. 2018;151:10-17.

Formeck, C, Swiatecka-Urban, A. Extra-renal manifestations of atypical hemolytic uremic syndrome. Pediatr Nephrol. 2018; Epub ahead in print. 

Fuhrman DY, Kane-Gill S, Goldstein SL, Priyanka P, Kellum JA. Acute kidney injury epidemiology, risk factors, and outcomes in critically ill patients 16-25 years of age treated in an adult intensive care unit. Ann Intensive Care. 2018; 8(1):26

Fuhrman DY, Kellum JA. Hyperchloremic IV solutions:  have we seen enough?...or “still good medicine?” Pediatr Crit Care Med C 2018; 19(2): 171-172

Hall, AM, Ayus JC, and Moritz ML, Things We Do For No Reason: The Default Use of Hypotonic Maintenance Intravenous Fluids in Pediatrics. J Hosp Med, 2018. 13(9): 637-640.

Joyce EL, DeAlmeida DR, Fuhrman DY, Priyanka P, Kellum JA. eResearch in Acute Kidney Injury: A Primer for Electronic Health Record Research; Nephrol Dial Transplant. 2018; Epub ahead of print.

Moritz, ML. Why 0.9% saline is isotonic: understanding the aqueous phase of plasma and the difference between osmolarity and osmolality. Pediatr Nephrol, 2018; Epub ahead of print

Moritz, ML and Ayus JC, Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med, 2018. 378(20): p. 1950.

Puri P, Schaefer CM, Bushnell D, Taglienti ME, Kriedberg JA, Yoder BK, Bates CM. Ectopic phosphorylated Creb marks dedifferentiated proximal tubules in cystic kidney disease. Am J Pathol. 2018; 188(1):84-89.

Yamada M, Nguyen C, Fadakar P, Ganoza A, Humar A, Shapiro R, Michaels MG, Green M. Epidemiology and outcome of chronic high Epstein-Barr viral load carriage in pediatric kidney transplant recipients. Pediatr Transplant. 2018; 22(3):e13147


Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker SL, Walensky LD, Hukriede NA, Ho J. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J. 2017;31(8):3540-54.

Dangle P, Salgado C, Reyes-Mugica M, Schneck F, Ost M, Sims-Lucas. Testicular hypoplasia is driven by defective vascular formation. Urology. 2017;101:94-8.

Fuhrman DY, Crowley K, Vetterly C, Hoshitsuki K, Koval A. Medication use as a contributor to fluid overload in the PIUC: A prospective observational study. J Pediatr Intensive Care. 2018;07(02):069-074.

Fuhrman DY, Kellum JA. Epidemiology and pathophysiology of cardiac surgery– Associated acute kidney injury. Curr Opin Anaesthesiol. 2017;30(1):60-5.

Fuhrman DY, Schneider MF, Dell KM, Blydt-Hansen TD, Mak R, Saland JM, Furth SL, Warady BA, Moxey-Mims MM, Schwartz GJ. Albuminuria, proteinuria, and renal disease progression in children with CKD. Clin J Am Soc Nephrol. 2017;12(6): 912-920.

Geramita MA, Hofer J, Cooper J, Moritz ML. Decreased severity of Shiga toxin– producing Escherichia coli haemolytic uraemic syndrome (STEC-HUS) in a child with type 1 von Willebrand disease. BMJ Case Rep. 2017.

Ikeda Y, Zabbarova I, Schaefer CM, Bushnell DS, de Groat WC, Kanai AJ, Bates CM. Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017;312(4): F607-18.

Joyce E, Ellis D, Miyashita Y. Chapter 14: Nephrology. In: Zitelli BJ, McIntire SC, Nowalk AJ (Eds.), Zitelli and Davis’ Atlas of Pediatric Physical Diagnosis (7th ed.). Philadelphia, PA: Saunders; 2017.

Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulointerstitial nephritis: Diagnosis, treatment, and monitoring. Pediatr Nephrol. 2017;32(4): 577-87.

Joyce E, Ho J, El-Gharbawy A, Salgado CM, Ranganathan S, Reyes-Mugica M. The value of renal biopsy in diagnosing infantile nephropathic cystinosis associated with secondary nephrogenic diabetes insipidus. Pediatr Dev Pathol. 2017;20(1): 72-5.

Miyashita Y, Flynn JT, Hanevold CD. Diagnosis and management of white-coat hypertension in children and adolescents: A Midwest Pediatric Nephrology Consortium study. J Clin Hypertens. 2017;19: 884-9.

Moritz ML, Ayus JC. How to improve intravenous fluid prescribing practices in bronchiolitis. Hosp Pediatr. 2017;7(5):300-2.

Mukherjee, E, Maringer KV, Papke E, Bushnell DS, Schaefer CM, Kramann R, Ho J, Humphreys BD, Bates CM, SimsLucas S. Endothelial markers expressing stromal cells are critical for kidney formation. Am J Physiol Renal Physiol. 2017;313(3):F611-F620.

Narla D, Slagle S, Schaefer CM, Bushnell DS, Puri P, Bates CM. Loss of peri-Wolffian duct stromal Frs2a expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux. Pediatr Res. 2017;82(6):1022-1029.

Peterson CG, Miyashita Y. The use of ambulatory blood pressure monitoring as standard of care in pediatrics. Front Pediatr. 2017;5:153.

Rodenbach KE, Fuhrman DY, Maier PS, Schwartz GJ. Renal response to a protein load in healthy young adults as determined by iohexol infusion clearance, cimetidine-inhibited creatinine clearance, and cystatin C estimated glomerular filtration rate. J Ren Nutr. 2017;4:275-81.

Sims-Lucas S, Good M, Vainio SJ. Editorial: Organogenesis: From development to disease. Front Cell Dev Biol. 2017;5:85.

Sindhi R, Higgs BS, Venkataramanan R, Moritz ML. Synergistic immunosuppression and unintended consequences. Pediatr Transplant. 2017;21(7).

Swiatecka-Urban A. Endocytic trafficking at the mature podocyte slit diaphragm. Front Pediatr. 2017;5:32.

Vermeren M, Lyraki R, Wani S, Airik R, Albagha O, Mort R, Hildebrandt F, Hurd Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases trabecular bone mass in mice. Mamm Genome. 2017;28(11-12):498-514.

Woroniecki R, Swiatecka-Urban A, Kaskel FJ. Editorial: Nephrotic syndrome in pediatric patients. Front Pediatr. 2017;3(5):167.

Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem. 2017;292(24):10239-49.


Airik R*, Schueler M, Airik M, Cho J, Porath JD, Mukherjee E, Sims-Lucas S, Hildebrandt F*. A FANCD2/FANCI-associated nuclease 1-knockout model develops karyomegalic interstitial nephritis. J Am Soc Nephrol. 2016 27(12):3552-9. *Co-corresponding authors

Airik R*, Schueler M, Airik M, Cho J, Ulanowicz KA, Porath JD, Hurd TW, Bekker-Jensen S, Schrøder JM, Andersen JS, Hildebrandt F*. SDCCAG8 interacts with RAB effector proteins RABEP2 and ERC1 and is required for hedgehog signaling. PLoS One. 2016;11(5):e0156081. *Co-corresponding authors

Ayus JC, Fuentes NA, Negri AL, Moritz ML, Giunta DH, Kalantar-Zadeh K, Nigwekar SU, Thadhani RI, Go AS, De Quiros FG. Mild prolonged chronic hyponatremia and risk for hip fracture in the elderly. Nephrol Dial Transplant. 2016. Oct;31(10):1662-9.

Bebee TW, Sims-Lucas S, Park JW, Bushnell D, Cieply B, Xing Y, Bates CM*, Carstens RP*. Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number. 2016. Dev Dyn. 245(10):991-1000. *Co-corresponding authors

Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA. N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov. 2016;2:16082.

Farinha CM, Swiatecka-Urban A, Brautigan DL, Jordan P. Regulatory crosstalk of protein kinases on CFTR trafficking and function. Front Chem. 2016;4:1.

Fuhrman DY, Kellum JA. Remote ischemic preconditioning in the PICU: A simple concept with a complex past. Pediatr Crit Care Med. 2016;17:e371-9.

Fuhrman DY, Kellum JA. Biomarkers for diagnosis, prognosis, and intervention in acute kidney injury. Contributions to Nephrology. 2016;187:47-54.

Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, Ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F. FAT1 mutations cause a glomerulotubular nephropathy. Nat Commun. 2016;7:10822.

Hemker SL, Sims-Lucas S, Ho J. The role of hypoxia in nephrogensis. Pediatr Nephrol. 2016;31(10):1571-7.

Joyce EL, Kane-Gill SL, Fuhrman, DY, Kellum JA. Drug-associated acute kidney injury: Who’s at risk? Pediatr Nephrol. 2016;32:59-69.

Liu X, Edinger RS, Klemens CA, Phua, YL, Bodnar AJ, LaFramboise WA, Ho J, Butterworth MB. A microRNA cluster miR-23~24~27 is upregulated by aldosterone in the distal kidney nephron where it alters sodium transport. J Cell Physiol. 2016 Sept 16.

Maringer K, Sims-Lucas S. The multifaceted role of the renal microvasculature during acute kidney injury. Pediatr Nephrol. 2016;31(8):1231-40.

Maringer K., Yarbrough A., Sims-Lucas S., Saheb E., Jawed S., Bush J. Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation. J Biosci. 2016;41(2):205-17.

Moritz ML, Ayus JC. Misconceptions in the treatment of dehydration in children. Pediatr Rev. 2016;37(7):e29-31.

Moritz ML, Ayus JC. Maintenance intravenous fluids in acutely ill patients. N Engl J Med. 2016;374(3):290-1.

Phua YL, Ho J. Renal dysplasia in the neonate. Curr Op Pediatr. 2016;28:209-15.

Puri P, Bushnell D, Schaefer CM, Bates CM. Six2creFrs2alpha knockout mice are a novel model of renal cystogenesis. Sci Rep. 2016;6:36736.

Shukla S, Basu A, Moritz ML. Use of hypotonic maintenance intravenous fluids and hospital-acquired hyponatremia remain common in children admitted to a general pediatric ward. Front Pediatr. 2016 4:90.

Squires J, Nguyen C. Complexity of pre-emptive liver transplantation in children with primary hyperoxaluria type 1. Pediatr Transplant. 2016;20(5)604-6.

Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV. Prorenin receptor is critical for nephron progenitors. Dev Biol. 2016;409(2):382-91.

Walker KA, Sims-Lucas S, Bates CM. Fibroblast growth factor receptor signaling in kidney and lower urinary tract development. Pediatr Nephrol. 2016;31(6):885-95


Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. Journal of Pediatrics. 2015;166:178-83.

Agathis NT, Libman IM, Moritz ML. Hyponatremia due to severe primary hypothyroidism in an infant. Front Pediatr. 2015; 3(96):1-4.

Ashokkumar C, Ganguly B, Townsend R, White J, Levy S, Moritz M, Mazariegos G, Sun Q, Sindhi R. Alloreactive CD154-expressing T-cell subsets with differential sensitivity to the immunosuppressant belatacept: Potential targets of novel belatacept-based regimens. Sci Rep. 2015; 5:15218.

Ayus JC, Caputo D, Bazerque F, Heguilen R, Gonzalez CD, Moritz ML. Treatment of hyponatremic encephalopathy with 3% sodium chloride protocol: A case series. Am J Kidney Dis. 2015; 65(3):435-42.

Ellis D, Lieb J. Hyperoxaluria and genitourinary disorders in children ingesting almond milk products. J Pediatr. 2015;167:1155-8.

Ellis D, Miyashita Y. Management of the hypertensive child. In: Avner E, Harmon W, Niaudet P, Yoshikawa N, eds. Pediatric Nephrology. Springer Berlin Heidelberg; 2015: 1-87.

Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM. Fibroblast growth factor receptor-Frs2a signaling is critical for nephron progenitors. Dev Biol. 2015;400(1):82-93.

Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015;70:84-5.

Joyce E, Ho J, El-Gharbawy A, Salgado CM, Ranganathan S, Reyes-Mugica M. The value of renal biopsy in diagnosing infantile nephropathic cystinosis associated with secondary nephrogenic diabetes insipidus. Pediatr Dev Pathol. 2015; 20(1):72-75.

Junttila S, Saarela U, Halt K, Manninen A, Parssinen H, Lecca MR, Brandli AW, Sims-Lucas S, Skovorodkin I, Vainio SJ. Functional genetic targeting of embryonic kidney progenitor cells ex vivo. J Am Soc Nephrol. 2015;26:1126-37.

Moritz ML, Ayus JC. Disorders of plasma sodium. N Eng J Med. 2015 Mar 26;372(13).

Moritz ML, Ayus JC. Hyponatraemia: Isotonic fluids prevent hospital-acquired hyponatremia. Nat Rev Nephrol. 2015;11(4):202-3.

Moritz ML, Ayus JC. Maintenance intravenous fluids in acutely ill patients. N Engl J Med. 2015;373(14):1350-60.

Phua YL, Ho J. MicroRNAs in the pathogenesis of cystic kidney disease. Curr Opin in Pediatr. 2015;27:219-26.

Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015;308(12):F1452-62.

Phua YL, Chu JYS, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Reports. 2015;3(10).

Rymer CC, Sims-Lucas S. In utero intra-cardiac tomato-lectin injections on mouse embryos to gauge renal blood flow. J Vis Exp. 2015;96.

Stolz DB, Sims-Lucas S. Unwrapping the origins and roles of the renal endothelium. Pediatric Nephrology. 2015;30:865-72.

Walker KA, Ikeda Y, Zabbarova I, Schaefer CM, Bushnell DS, de Groat WC, Kanai AJ, Bates CM. Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2015;308(8):F888-98.

Webb TN, Griffith H, Miyashita Y, Bhatt R, Jaffe R, Moritz M, Hofer J, Swiatecka-Urban A. Atypical hemolytic uremic syndrome and chronic ulcerative colitis treated with eculizumab. Int J Med Pharm Case Reports. 2015;4(5):105-12