The Jacqueline Ho laboratory focuses on understanding how microRNAs (miRNAs) regulate kidney development and disease. MiRNAs are small, non-coding RNA molecules that function as negative regulators of gene expression. Her laboratory has recently shown that miRNAs are involved in regulating the proliferation, survival, and differentiation of nephron progenitors, which give rise to the nephron, the functional unit in the kidney. To make an impact on patients with CKD, the lab is studying how miRNAs are involved in determining how many nephrons are formed during kidney development and in normal nephron formation.
Dr. Ho’s lab has also begun basic science studies on how certain in utero exposures may affect kidney development, specifically maternal diabetes and hypoxia, and how this might impact the risk of chronic kidney disease in children.
Ho J, Ng KH, Rosen S, Dostal A, Gregory RI and Kreidberg JA. Podocyte-specific loss of functional miRNAs leads to rapid glomerular and tubular damage. J Am Soc Neph 2008; 19(11): 2069-2075. PMID: 18832437.
Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S and Kreidberg JA. The pro-apoptotic protein Bim is a microRNA target in kidney progenitor cells. J Am Soc Neph 2011; 22(6): 1053-1063. PMID 21546576.
Chu JYS, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg J and Ho J. Dicer function is required in the metanephric mesenchyme in early kidney development. Am J Physiol Renal Physiol 2014; 306(7): F764-72. PMID 24500693.
Marrone AK, Stolz DB, Bastacky SI, Kostka D, Bodnar AJ and Ho J. miR-17~92 is required for nephrogenesis and renal function. J Am Soc Neph 2014; 25(7): 1440-1452. PMID 24511118.
Phua YL, Chu JYS, Marrone AK, Bodnar AJ, Sims-Lucas S and Ho J. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Reports 2015 Oct; 3(10); pii: e12537. doi: 10.14814/phy2.12537. PMID 26438731.
Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker SL, Walensky LD, Hukriede NA and Ho J. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J, 2017 Aug; 31(8): 3540-3554. PMID28446592.