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Aaron Michael Altman, MD, PhD

  • Resident, PGY-3

Aaron M. Altman is a PGY-1 pediatric resident physician at UPMC Children’s Hospital of Pittsburgh in the Physician Scientist Development Program. He received his Bachelor of Arts degree from Pomona College in Claremont, CA and his Doctor of Medicine and Doctor of Philosophy in Microbiology and Immunology degrees from the State University of New York Upstate Medical University in Syracuse, NY. Altman is a virologist with interests in host-pathogen interaction and viral pathogenesis. His prior dissertation research focused on how human cytomegalovirus (HCMV), a herpesvirus that contributes to significant pediatric morbidity and mortality, controls cellular survival pathways in human monocytes. His current focus includes immune modulation of human metapneumovirus infection.

Resident Biographical Details

Hometown

Woodbridge, Connecticut

College or Medical School

SUNY Upstsate Medical University

Education & Training

  • BA, Molecular Biology, Pomona College, 2013
  • MD, cum laude, State University of New York Upstate Medical University, 2021
  • PhD, Microbiology and Immunology, State University of New York Upstate Medical University, 2021

Selected Publications

Altman, Aaron M., et al. “HCMV Modulation of Cellular PI3K/Akt/MTOR Signaling: New Opportunities for Therapeutic Intervention?” Antiviral Research, vol. 163, 2019, pp. 82–90., doi:10.1016/j.antiviral.2019.01.009.

Peppenelli, Megan A., Miller, Michael J., Altman, Aaron M., Chan, Gary C. “Aberrant Regulation of the Akt Signaling Network by Human Cytomegalovirus Allows for Targeting of Infected Monocytes.” Antiviral Research, vol. 158, 2018, pp. 13–24., doi: 10.1016/j.antiviral.2018.07.015.

Cojohari, Olesea, Mahmud, Jamil, Altman, Aaron M., Peppenelli, Megan A., Miller, Michael J., Chan, Gary C. “Human Cytomegalovirus Mediates Unique Monocyte to Macrophage Differentiation Through the PI3K/SHIP1/Akt Signaling Network.” Viruses, vol 12, 2020, doi: 10.3390/v12060652

Altman, Aaron M., Mahmud, Jamil, Smith, Nicholas A., Miller, Michael J., Chan, Gary C. “Human Cytomegalovirus-Induced Autophagy Prevents Necroptosis of Infected Monocytes.” J Virol 94:e01022-20. https://doi.org/10.1128/JVI.01022-20

Mahmud, Jamil, Miller, Michael J., Altman, Aaron M., Chan, Gary C. “Human Cytomegalovirus Glycoprotein-Initiated Signaling Mediates the Aberrant Activation of Akt.” Journal of Virology, vol 94, 2020, pp 167-200, doi: 10.1128/JVI.00167-20