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Abbe N. de Vallejo, MSc, PhD

  • Emeritus, Department of Pediatrics

Administrative Assistant: Beckie Pomycala

Abbe de Vallejo is Emeritus Faculty in the Department of Pediatrics. He obtained an MSC in Pathobiology from the University of Stirling, Scotland, a PhD in Microbiology and Immunology from the University of Mississippi Medical Center, and Postdoctoral trainings in Molecular Immunology and Rheumatology from Mayo Clinic College of Medicine. Before coming to Pittsburgh, he was Associate Consultant in Rheumatology and Assistant Professor of Medicine at Mayo Medical School. At University of Pittsburgh, he held faculty appointments in the Department of Immunology and McGowan Institute for Regenerative Medicine and the Division of Rheumatology, UPMC Children’s Hospital of Pittsburgh. He served as Scientific Director of the Flow Cytometry Core of the John G. Rangos Sr. Research Center and had been involved in various educational programs of the University and in the continuing education programs of UPMC. de Vallejo continues to serve in the editorial boards of Frontiers in Immunology and Aging and Disease journals. He is Fellow of the Royal Society of Medicine. 

Professional and Scientific Society Memberships

  • The Royal Society of Medicine
  • Gerontological Society of America
  • American College of Rheumatology
  • American Association of Immunologists

 

Education & Training

  • SCM, Pathobiology, University of Stirling
  • PhD, Immunology & Microbiology, University of Mississippi Medical Center
  • Postdoctoral, Molecular Immunology, Mayo Clinic College of Medicine
  • Postdoctoral, Mayo Clinic College of Medicine

Selected Publications

Hoffman RA, Huang S, Chalasani G, Vallejo AN. 2021. Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice. Aging Dis. 2021 Aug 1;12(5):1183-1196.

Vallejo AN, Mroczkowski HJ, Michel JJ, Woolford M, Blair HC, Griffin P, McCracken E, Mihalik SJ, Reyes-Mugica M, Vockley J. 2021. Pervasive inflammatory activation in patients with deficiency in very-long-chain acyl-coA dehydrogenase (VLCADD). Clin Transl Immunology. 2021 Jun 27;10(6):e1304. AAAS EurekAlert news: https://www.eurekalert.org/pub_releases/2021-06/uop-pic062821.php. 

Vallejo AN, Reed AM, Bending D, Van Wijk F, Wedderburn LR. (eds). 2021. Immunophysiology of Pediatric Rheumatic Diseases. Lausanne: Frontiers Media SA. eBook, doi:10.3389/978-2-88971-784-2.

Kuniholm MH, Bramah-Lawani M, Fitzpatrick M, Nouraie M, Qin S, Huang L, Vallejo AN, Landay AL, Morris A. 2021. Association of Monocyte Migration Marker CD11b With Pulmonary Function in People Living With HIV. J Acquir Immune Defic Syndr. 2021 Mar 1;86(3):344-352.

Kritschil R, Zhao S, Dong Q, Lee J, Conover CA, Sowa G, Vallejo AN, Vo N. 2020. Effects of suppressing bioavailability of insulin-like growth factor on age-associated intervertebral disc degeneration. JOR Spine. 2020 Jul 27;3(4):e1112. 

Rajakumar K, Moore CG, Khalid A, Vallejo AN, Virji M, Holick MF, Greenspan SL, Arslanian S, Reis SE. 2020. Effect of Enhanced vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: A randomized clinical trial. Amer J Clin Nutr 111(4):757-768. PMC7138671. Editorial feature: https://doi.org/10.1093/ajcn/nqaa021.

Shaaban CE, Aizenstein HJ, Jorgensen DR, Mahbubani RLM, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C. Physical Activity and Cerebral Small Vein Integrity in Older Adults. Med Sci Sports Exerc. 2019 Aug;51(8):1684-1691.

Ferguson ID, Griffin P, Yano H, Gaffen SL, Piganelli JD, Dvergsten JA, Michel JJ, Rosenkranz ME, Kietz DA, Vallejo AN. 2018. CD31/IL17-driven inflammatory axis shapes synovitis in juvenile idiopathic arthritis. Frontiers Immunol 9:1802. 

Shaaban CE, Aizenstein HJ, Jorgensen DR, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Cohen R, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C. 2017. In Vivo Imaging of Venous Side Cerebral Small Vessel Disease in Older Adults: An MRI Method at 7T. Am J Neuroradiol 38(10):1923-1928. 

Griffin P, Michel JJ, Vallejo AN. 2018. Diversity of CD28null T cells in the elderly: A glimpse into biological adaptation of aging. Handbook in Immunosenescence. doi:10.1007/978-3-319-64597-1_87-1.

He M, Kratz LE, Michel JJ, Vallejo AN, Ferris L, Kelley RI, Hoover JJ, Jukic D, Gibson KM, Wolfe L, Ramachandran D, Zwick ME, Vockley J. 2011. Mutations in the SC4MOL gene encoding a novel methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay. J Clin Invest 121: 976-984. 

Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA. 2009. Resistance to age-dependent thymic atrophy in long-lived mice that have deficiency in pregnancy-associated plasma protein A. Proc Nat Acad Sci USA 106:11252-11257. AAAS EurekAlert news: https://www.eurekalert.org/pub_releases/2009-07/uops-cho071009.php. 

Lopez de Padilla C, Vallejo AN, Lacomis D, McNallan KT, Reed AM. 2009. Extra-nodal lymphoid microstructures in inflamed muscle and disease severity in new-onset juvenile dermatomyositis. Arthritis Rheum 60:1160-1172. 

Full Publication List via NIH PubMed  »

Academic and Research Interests

  • Biology of pediatric and adult rheumatic diseases
  • Immune repertoire remodeling in aging and autoimmunity
  • Integrative physiology of aging across the lifespan
  • Immunobiology of obesity and lipid disorders