Agnieszka Swiatecka-Urban studied the regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells. One focus of her research activity has been the characterization of mechanisms and pathways that regulate the cystic fibrosis transmembrane conductance regulator (CFTR) in order to improve treatment strategies for cystic fibrosis (CF). Swiatecka-Urban has also used her expertise to address a significant unmet need of patients with nephrotic syndrome, a severe form of kidney disease responsible for 20% of pediatric kidney failure. She has been studying the role of protein-protein interactions in the dynamic regulation of nephrin in the podocyte slit diaphragm—an intercellular junction, which is compromised in nephrotic syndrome. Swiatecka-Urban’s work on both nephrin and CFTR has resulted in several successful research awards. Her research was supported by an NIH R56 Award, an NIH P30 Pilot and Feasibility Sub-award, an NIH Cooperative Agreement Sub-award, and an American Heart Association grant. Finally, she led the University of Pittsburgh site for the CureGlomerulopathy (CureGN) network cohort study–a multicenter, prospective cohort observational study for patients with nephrotic syndrome.
Major Lectureships and Seminars
- “Role of microRNA 145 in TGFβ1-mediated Repression of CFTR in Primary Human Bronchial Epithelium.” the 131st Salt and Water Club Meeting, University of Pittsburgh School of Medicine, 2016.
- “Incidence of Pediatric Nephrotic Syndrome – Single Center Experience.” The National Kidney Foundation & Kidney and Urology Foundation of America Nephrotic Syndrome Symposium, New York, NY, 2016.
Professional Affiliations/Society Memberships
- American Society of Nephrology
- American Society of Pediatric Nephrology
- International Pediatric Nephrology Association
- International Society of Nephrology
- Salt and Water Club
- Society for Pediatric Research
- Research and Research Training Committee, Cystic Fibrosis Foundation
- Basic Cell MSO1 Study Section, American Heart Association
- Ad hoc reviewer, Digestive, Kidney, and Urological Systems, NIH
- Review Committee, University of Pittsburgh Competitive Medical Research Fund
- Research Council United Kingdom
- University of Pittsburgh Competitive Research Fund
- Research Fellowship Grants Committee, Mallinckrodt Pharmaceuticals
- Innovative Research Grant Basic Science 3 Study Section, American Heart Association