Alexa N. Roth, PhD

  • Postdoctoral Fellow

Administrative Assistant: Colleen Kelly

Dr. Alexa Roth joined the laboratory of Dr. Terence Dermody at the University of Pittsburgh in early 2020. As a postdoctoral fellow, she contributes to hands-on work in the lab and collaborates with her labmates to advance research in virology. Alexa discovered her passion for viral pathogen-host interactions while engaged in undergraduate studies at the University of Florida (UF). Upon receiving her BSc in microbiology and cell science, she remained at UF to pursue doctoral studies in the Graduate Program in Biomedical Sciences, where she studied links between cells infected by norovirus and development of diarrheal disease under the mentorship of Dr. Stephanie Karst. Alexa received her PhD from the University of Florida in 2019. Here in the Department of Pediatrics, Alexa is currently researching aspects of reovirus pathogenesis in the gastrointestinal tract. She plans to develop a research program studying enteric virus biology as she pursues a career as an independent scientist in academia.

Education & Training

  • BSc, University of Florida, 2014
  • PhD, University of Florida, 2019

Selected Publications

Roth AN*, Helm EW*, Mirabelli C, Kirsche EM, Smith JC, Eurell LB, Ghosh S, Altan-Bonnet N, Wobus CE, and Karst SM. Norovirus infection causesacute self-resolving diarrhea in wild-type neonatal mice. Nat Commun 2020.** *authors contributed equally **in press

Roth AN, Grau KR, and Karst SM.Diverse mechanisms underlie enhancement of enteric viruses by the mammalian intestinal microbiota. Viruses 2019. doi: 10.3390/v11080760.

Grau KR*,Roth AN*, Zhu S*, Hernandez A, Colliou N, DiVita BD, Philip D, Riffe C, Mohamadzadeh M, Giasson B, Wallet SM, and Karst SM. The major targets of anorovirus during acute infection are immune cells in the gut-associated lymphoid tissue. Nat Micobiol 2017. doi: 10.1038/s41464-017-0057-7. 

Roth AN and Karst SM. Norovirus mechanisms of host immune antagonism. Curr Opin Virol 2015. doi: 10.1016/j.coviro.2015.11.005.

Coleman CB, McGraw JE, Feldman ER, Roth AN, Keyes LR, Grau KR, Cochran S, Waldschmidt TJ, Liang C, Forrest JC, and Tibbetts SA. Agammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. PLoS Pathog 2014.doi: 10.1371/journal.ppat.1003916.

Research Interests

  • Virology
  • Pathogenesis
  • Enteric infections