Alexis L. Franks, MD, FAAP

  • Assistant Professor of Pediatrics
  • Director of Education, Child Development Unit

Alexis L Franks, MD, FAAP is an assistant professor of pediatrics at the University of Pittsburgh School of Medicine in the Divisions of Child Neurology and Child Development. She is the director of education for the Child Development Unit and is responsible for supervising, organizing, and coordinating medical education in Neurodevelopmental Disabilities and Developmental Behavioral Pediatrics for Child Neurology residents, Pediatrics residents, University of Pittsburgh Medical Students, amongst many other learners and medical trainees from multidisciplinary backgrounds. She is also the co-director for the University of Pittsburgh School of Medicine Neuroscience Foundations Course. Dr. Franks graduated magna cum laude with her Bachelor of Arts degree from The Colorado College in Colorado Springs, CO, where she was inducted into the Phi Beta Kappa Honor Society. She completed medical school at the University of Colorado at Denver School of Medicine, where she was inducted into the Alpha Omega Alpha Honor Medical Society. As a medical student, she received the Franklin Gengenbach Award for outstanding performance in pediatrics. She completed her residency in Neurodevelopmental Disabilities at the UPMC Children’s Hospital of Pittsburgh prior to joining the faculty. She has been inducted as a Fellow of the American Academy of Pediatrics. Dr. Franks’s clinical practice is located at the UPMC Children’s Hospital of Pittsburgh Child Development Unit where she provides diagnostic recommendations and medical management to children with neurodevelopmental disabilities, including developmental delays and intellectual disability, neurogenetic conditions, mitochondrial disease, autism spectrum disorders, epilepsy, and ADHD, in addition to many other neurologic and developmental conditions. Dr. Franks has an academic interest in both undergraduate and graduate medical education, and specifically developing novel approaches and tools for education in neurodevelopmental disabilities.

She has participated in preclinical research investigating how perinatal exposures to glucocorticoids and complications of prematurity can influence early life brain development. She is engaged in clinical research evaluating how variable levels of trust in physicians and allopathic medicine by families of children with neurodevelopmental disabilities relates to medical outcomes, with a goal to develop provider-centric strategies to optimize relationships with families. She is a passionate advocate for patients, and she levies her education background to develop resources and support families as they navigate through obtaining resources and social supports and accessing special education services.

Professional and Scientific Society Memberships

  • American Academy of Neurology, 2014-Present 
  • American Academy of Pediatrics, 2012-Present 
  • American Medical Association, 2008-Present 
  • Child Neurology Society, 2017-Present 
  • Society for Neuroscience, 2017-Present 
  • Pennsylvania Medical Society, 2018-2019 

Education & Training

  • BA, Biochemistry, The Colorado College, 2007
  • MD, University of Colorado at Denver School of Medicine, 2012
  • Residency in Pediatrics, UPMC Children’s Hospital of Pittsburgh, 2012-2014
  • Residency in Neurodevelopmental Disabilities, UPMC Children’s Hospital of Pittsburgh, 2014-2018

Selected Publications

Stephens SH, Logel J, Barton A, Franks A, Schultz J, Short M, Dickenson J, James B, Fingerlin TE, Wagner B, Hodgkinson C, Graw S, Ross RG, Freedman R, Leonard S.  Association of the 5’ upstream regulatory region of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.  Schizophrenia Res. 2009 Apr;109(1-3):102-112. PubMed PMID: 19181484. PubMed Central PMCID: PMC2748327.

Stephens SH, Franks A, Berger R, Palionyte M, Freedman R, Leonard S.  Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.  Psychiatr Genet.  2012 Feb;22(1):1-14.  PubMed PMID: 21970977. PubMed Central PMCID: PMC3878876.

Toro C, Hori RT, Malicdan MCV, Tifft CJ, Goldstein A, Gahl WA, Adams DR, Harper F, Wolfe LA, Xiao J, Khan MM, Tian J, Hope KA, Reiter LT, Tremblay MG, Moss T, Franks AL, Balak C; C4RCD Research Group, LeDoux MS.  A recurrent de novo missense mutation in UBTF causes developmental neuroregression. Hum Mol Genet. 2018 Feb 15; 27(4): 691–705.  PubMed PMID: 29300972. PubMed Central PMCID: PMC5886272.

Carson RA, Rudine AC, Tally SJ, Franks AL, Frahm KA, Waldman JK, Silswal N, Burale S, Phan JV, Chandran UR, Monaghan AP, DeFranco DB.  Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms. PLoS One. 2018 May 8;13(5):e0196387. doi: 10.1371/journal.pone.0196387. PubMed PMID: 29738536. PubMed Central PMCID: PMC5940229.

Jaumotte JD*, Franks AL*, Bargerstock EM, Kisanga EP, Menden HL, Ghersi A, Omar M, Wang L, Rudine A, Short KL, Silswal N, Cole TJ, Sampath V, Monaghan-Nichols AP, DeFranco DB. Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum. Neurobiol Dis. 2021 Jun 11:105422. doi: 10.1016/j.nbd.2021.105422. Epub ahead of print. PMID: 34126164. *co-first authors

 

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Academic and Research Interests

  • Neurodevelopmental disabilities
  • Trust
  • Autism
  • Alternative medicine
  • Medical education
  • Child neurology
  • Epilepsy