Amitava Mukherjee’s overarching goal is to uncover key molecular signaling pathways for exocrine pancreatic disorders, particularly drug-induced pancreatitis. Currently, his research focuses on deciphering the mechanisms underlying asparaginase-associated pancreatitis. The research suggests that pancreatic asparagine synthetase (ASNS) maintains acinar cell homeostasis and that its upregulation is required to mitigate asparaginase-induced pancreatic cell injury. Therefore, therapies that selectively augment pancreatic ASNS could be used to alleviate asparaginase-associated pancreatitis. He has generated sufficient preliminary data for grant submissions. Mukherjee has published work in collaboration with the Mark Lowe Laboratory on a mutant lipase that is responsible for chronic pancreatitis in the Journal of Biological Chemistry. He has written a chapter for Liver Disease in α1-Antitrypsin Deficiency. Mukherjee has been assisted by his research team, consisting of a postdoctoral fellow, Nayyar Ahmed, PhD; a medical fellow, Fateema Rose, MD; and a visiting researcher, Li-Hui Deng. Mukherjee has participated in training two summer students, Chaitanya Srinivasan, and Mahedah Rehman.