Andrew P. Feranchak, MD
- Division Director, Gastroenterology, Hepatology and Nutrition, Carol Ann Craumer Endowed Chair for Pediatric Research, and Professor of Pediatrics
Andrew Feranchak, MD is the Director of the Division of Pediatric Gastroenterology, Hepatology and Nutrition and is an internationally recognized investigator in the area of cholestatic liver diseases. He is a native of Pittsburgh and received his MD degree from the University of Pittsburgh School of Medicine and completed his residency in Pediatrics at UPMC Children's Hospital of Pittsburgh. He completed a fellowship in Pediatric Gastroenterology, Hepatology and Nutrition at the University of Colorado and is board certified in Pediatric Gastroenterology. Dr. Feranchak was a faculty member at UT Southwestern Medical Center in Dallas beginning in 2004 and served as Division Director of Pediatric Gastroenterology there from 2011 until 2017 when he returned to Pittsburgh.
Dr. Feranchak's own NIH-funded research focuses on understanding the basic mechanisms of bile formation, which may serve as the basis for therapeutic strategies for the treatment of cholestatic liver disorders. He has aurthored significant publications in the field and has served on the editorial board for several leading journals, including the Journal of Pediatric Gastroenterology and Nutrition and Hepatology. He has lectured extensively and served in numerous academic leadership positions including the Society of Pediatric Gastroenterology, Hepatology, and Nutrition (NASPHGAN), the American Association for the Study of Liver Dieseases (AASLD), and the Society for Pediatric Research (SPR).
Education & Training
- BS, Pre-Medicine, High Honors, University of Notre Dame, 1988
- MD, University of Pittsburgh School of Medicine, 1992
- Internship and Residency in Pediatrics, University of Pittsburgh-UPMC Children's Hospital of Pittsburgh, 1992-1995
- Fellowship in Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Health Sciences Center, 1995-1998
- Research Scholar in Hepatobiliary Transport, University of Colorado Health Sciences Center, 1998-1999
- Trainee in Ion Channel Physiology, Cold Spring Harbor Laboratory, 2002
Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser S, Alpini G, Feranchak AP. ATP release and P2 receptor-mediated secretion in small and large mouse cholangiocytes. Hepatology 2010; 52:1819-1828.
Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. J Biol Chem 2011; 286:766-776.
Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP. Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles. J Biol Chem 2011; 286:25363-76.
Mendoza JL, Schmidt A, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ. Requirements for efficient correction of F508 CFTR revealed by analyses of evolved sequences. Cell, 2012; 148:164-74.
Geiser JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C. Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion. Endocrinology 2013; 154(2):675-84.
Dutta AK, Woo K, Khimgi AK, Kresge C, Feranchak AP. Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEME16A. Am J Physiol Gastrointest Liver Physiol 2013; 304(1): G87-98.
Li Q, Kresge C, Bugde A, Lamphere M, Park J, Feranchak AP. Regulation of mechanosensitive biliary epithelial transport by the epithelial Na+ channel, ENaC. Hepatology, 2016; 63(2):538-492016.
Dutta AK, Khimji AK, Liu S, Karamysheva Z, Fujita A, Kresge C, Rockey DC, Feranchak AP. PKC regulates TMEM16A-mediated Cl- secretion in human biliary cells. Am J Physiol Gastrointest Liver Physiol. 2016; 310(1): G34-42.
Li Q, Dutta A, Kresge C, Bugde A, Feranchak AP. Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A (TMEM16A) Cl-channels. Hepatology, 2018; 68(1):187-199.
Li Q, Kresge C, Feranchak AP. The mechanosensory transient receptor potential vanilloid member 4 (TRPV4) regulates mouse cholangiocyte secretion and bile formation. Am J Physiol Gastrointest Liver Physiol 2020; 318(2):G277-G287.
Dutta A, Boggs K, Khimji A, Getachew Y, Wang Y, Kresge C, Rockey D, Feranchak AP. Signalling through the interleukin-4 and interleukin-13 receptor complexes regulate cholangiocyte TMEM16A expression and biliary secretion. Am J Physiol Gastrointest Liver Physiol 2020; 318(4):G763-G771.
Academic and Research Interests
- Hepatobiliary transport
- Regulation of biliary secretion and mechanisms of bile formation
- Purinergic signaling in hepatobiliary function and cell volume regulation
- Treatment of pediatric cholestatic liver disease
- Cystic Fibrosis-associated liver and biliary disease
- Assessment of fat-soluble vitamin status during cholestasis and cystic fibrosis
NIH 1P30DK120531-01, Pittsburgh Liver Research Center (Co-I and Associate Director, 5% effort, PI: Paul Monga), 2019-2024, $90,780.
Cystic Fibrosis Foundation Clinical Fellowship Training Grant (PI), 2019-2021, $129,000.
NIH 1R01DK119435-01A1, Beta-catenin-driven hepatobiliary reprogramming as a therapeutic modality for cholangiopathies (Collaborator, 5% effort, PI: Nejak-Bowen), 2019-2024, $1,575,000.
NIH 5U01DK062466, The Pittsburgh Cholestatic Liver Disease Consortium (Co-I), 2019-2024, $1,315,000.