Anthony James Lentscher, PhD

  • Postdoctoral Fellow

Dr. Anthony Lentscher joined the Department of Pediatrics as a graduate student in the laboratory of Dr. Terence Dermody in May 2016. Following successful defense of his dissertation, he works as a post-doctoral fellow in the Dermody lab, where his primary research interest is in virus-host interactions and viral pathogenesis.

Currently, he investigates the role of chikungunya virus (CHIKV) tissue tropism in disease development. CHIKV is a mosquito-transmitted alphavirus that periodically emerges to cause large epidemics of arthritic disease. The virus exhibits a broad tropism in the mammalian host, and it is unclear how replication at discrete sites affects pathogenesis. Dr. Lentscher has contributed to the discovery that replication in cells of the skeletal muscle promotes severe disease, and he is currently evaluating the capacity of a virus incapable of replication in myofibers as a vaccine candidate.

Prior to joining the University of Pittsburgh, Dr. Lentscher completed his undergraduate education at Tennessee Technological University, where he studied biochemistry and health sciences. Once his time in the Dermody lab concludes, he will be attending medical school and intends to pursue a career as a physician-scientist.

Professional and Scientific Society Memberships

  • American Society of Biochemistry and Molecular Biology, 2013-2015
  • American Chemical Society, 2013-2015
  • American Society for Virology, 2015-Present

Education & Training

  • BS, Chemistry-Biochemistry, summa cum laude, Tennessee Technological University, 2014
  • BS, Biology-Health Sciences, summa cum laude, Tennessee Technological University, 2014
  • PhD, Molecular Virology and Microbiology, University of Pittsburgh, 2020

Selected Publications

Ashbrook, A. W., Lentscher, A. J., Zamora, P. F., Silva, L. A., May, N. A., Bauer, J. A., Morrison, T. E., and Dermody, T. S. Antagonism of the sodium-potassium ATPase impairs chikungunya virus infection. mBio 7:e00693, 2016. PMCID: PMC4895112

Lentscher, A.J., McCarthy, M.K., May, N.A., Davenport, B.J., Montgomery, S.A., Raghunathan, K., McAllister, N., Silva, L.A., Morrison, T.E., and Dermody, T.S. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest 130:1466-1478, 2019.

Full Publication List via NIH PubMed »