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Archana Ramgopal, DO
- Assistant Professor of Pediatrics
Ramgopal is currently an Assistant Professor of Pediatrics at UPMC Children’s Hospital of Pittsburgh in the division of Bone Marrow Transplantation & Cellular Therapies. Her research interests include the study of post-bone marrow transplant immune complications including graft-versus-host disease (GVHD). She is exploring the role of cellular energy sensor AMP-activated protein kinase (AMPK) in human T cells, studies which could pave the way for modulating AMPK expression as a means to prevent GVHD in human clinical trials.
Education & Training
- BS, Carnegie Mellon University, 2012
- DO, Lake Erie College of Osteopathic Medicine, 2016
- Residency in Pediatrics, Cleveland Clinic Foundation
- Fellowship in Pediatric Hematology- Oncology, Children's Hospital of Pittsburgh
- Fellowship in Pediatric Bone Marrow Transplantation and Cellular Therapies, UPMC Children's Hospital of Pittsburgh
Selected Publications
Taylor, M. D., Sadhukhan, S., Kottangada, P., Ramgopal, A., Sarkar, K., D’Silva, S., ... Vyas, Y. M. Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott- Aldrich syndrome. Science Translational Medicine. 2010; 2(37).
Dhir, A., Demarsh, S., Ramgopal, A., Worley, S., Auron, M., Hupertz, V., & Onimoe, G. Central Venous Line Associated Deep Vein Thrombosis in Hospitalized Children. Journal of Pediatric Hematology/Oncology. 2019; 41(7), E432–E437.
Nasir, H., Ghannam, S., Gill, S., Studeny, S., Abrahan, D., Ramgopal, A., ... Gill, A. 104. Identifying Patients At Risk Of Clinical Deterioration Prior To PICU Transfer. Academic Pediatrics. 2019; 19(6), e46–e47.
Ramgopal, A., Lauko, A., Rotz, S., & Hanna, R. Safety of allogeneic hematopoietic stem cell transplantation in beta-thalassemia patients with chronic hepatitis C infections treated at a pediatric center. Pediatric Transplantation. 2019; 23(6).
Goldenberg M, Ramgopal A, Salgado CM, et al. Mesenchymal chondrosarcoma of the chest wall in an adolescent patient: A case report and brief review of the literature. Cancer Rep (Hoboken). 2021;e1453. PMID: 34132499
Ramgopal A, Segal J, Mukhtar S, et al. A chronic eyelid lesion in a child: multi-disciplinary approach to diagnosis, treatment and management of a highly atypical histiocytic lesion. Pediatr Hematol Oncol. 2021;1–7. PMID: 34379045
Ramgopal A, Sun LK, Byersdorfer CA. The role of AMP-activated protein kinase in GVHD-causing T cells. Immunometabolism (Cobham). 2022 Oct 7;4(4):e00009. doi: 10.1097/IN9.0000000000000009. PMID: 36275779; PMCID: PMC9561229.
Erica Braverman, Margaret McQuaid, Darlene Monlish, Andrea Dobbs, Manda Ramsey, Archana Ramgopal, Harrison Brown, Craig Byersdorfer. Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function. Preprint 2022. bioRxiv 2022.10.01.510473.
Ramgopal A, Braverman EL, Sun LK, Monlish D, Wittmann C, Ramsey MJ, Caitley R, Hawse W, Byersdorfer CA. AMPK Drives Both Glycolytic and Oxidative Metabolism in T Cells During Graft-versus-host Disease. bioRxiv [Preprint]. 2023 Jun 13:2023.06.12.544686. PMID: 37398326
Research Grants
CHP Summer Undergraduate Research Experience (SURP) Grant, 2010
Department of Pediatrics T32 NIH Award, 2020 - 2021
American Society of Hematology Research Training Award for Fellows, 2022
Hyundai Hope on Wheels Young Investigator Award, 2023 - 2025