Bernhard Kühn, MD
- Associate Professor of Pediatrics and Director, Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT)
- Associate Director, Richard King Mellon Foundation Institute for Pediatric Research
Understanding the unique workings of heart muscle cells - cardiomyocytes - is the passion of physician-scientist Bernhard Kühn. He and his team of researchers are focused on discovering ways to make cardiomyocytes replicate and proliferate, so as to enable the heart to heal itself in cases of heart failure or congenital defects.
A pioneer in this area of study, Kühn is the recipient of numerous grants and awards, including the American College of Cardiology's prestigious Young Investigator Award, the Basil O'Connor Award from the March of Dimes Birth Defects Foundation, and Scientist Development Grant from the American Heart Association, to name a few.
Professional and Scientific Society Memberships
- American Academy of Pediatrics, 1999-2008
- American College of Cardiology, 2002-Present
- American Heart Association, 2004-Present
- American Association for the Advancement of Science, 2007-Present
- American Society for Clinical Investigation, 2016-Present
Education & Training
- MD, Freie Universität Berlin, 1999
- Resident Physician, Yale-New Haven Hospital, 1999-2002
- Clinical Fellow, Boston Children's Hospital/Harvard Medical School, 2002-2007
- Post-doctoral Research Fellow, Boston Children's Hospital/Harvard Medical School, 2004-2005
Liu H, Lewarchik CM, Ammanamanchi N, Rao K, Mich-Basso JD, Stolz DB, Sullivan ML, Mistry S, Kellam B, Wu Y, Gotthardt M, Salama G, Kühn B. β-adrenergic receptor activity mediates between contraction and proliferation in heart muscle cells. Suppression of contractions in cycling cardiomyocytes is mediated by altered β-adrenergic receptor signaling. Revised manuscript in preparation for resubmission
Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy G, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu Y & Kühn B. Lamin B2 levels regulate polyploidization of cardiomyocyte nuclei and myocardial regeneration. Dev. Cell 2020, in press.
Liu H, Zhang C-H, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML and Kühn B. Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci. Transl. Med. 2019; 11(513): eaaw6419. PMID: 31597755, PMCID: pending
Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kühn B, Cuervo AM, Muzumdar R. Humanin is an endogenous activator of chaperone- mediated autophagy. J Cell Biol 2018; 217(1): 635–647. PMCID: pending
Missinato M, Saydmohammed M, Zuppo DA, Rao KS, Opie GW, Kühn B, Tsang M. Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development 2018; 145(5): dev157206. PMCID: pending
Ganapathy B, Polizzotti BD, Bennett D, Nandhagopal N, Kühn B. Neuregulin-1 administration protocols sufficient for stimulating cardiac regeneration in young mice do not induce somatic, organ, or neoplastic growth. PLoS One 2016; 11(5): e0155456, PMID: 27175488, PMCID: PMC4866786
Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nature Protocols 2016; 11: 542–552, PMID: 26890681.
Dueck H, Khaladkar M, Kim TK, Spaethling JM, Francis C, Suresh S, Fisher SA, Seale P, Beck SG, Bartfai T, Kühn B, Eberwine J, Kim J. Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation. Genome Biol. 2015;16:122, PMID: 26056000, PMCID: PMC4480509.
Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennet D, dos Remedios C, Haubner BJ, Penninger JM, Kühn B. Stimulation of cardiomyocyte regeneration in neonatal mice and in human myocardium with neuregulin reveals a therapeutic window. Sci. Transl. Med. 2015;7(281):281ra45. PMCID: PMC5360874
Bersell K, Choudhury S, Mollova M, Polizzotti BD, Ganapathy B, Walsh S, Wadugu B, Arab S, Kühn B. Moderate and high amounts of tamoxifen in a-MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis. Model. Mech. 2013; 6(6):1459-1469, PMID: 23929941, PMCID: PMC3820268
15CVD03, Eliciting Heart Regeneration through Cardiomyocyte Division, (PI, effort 5%), 2015-2020, $600,00
A function for B-type lamins in nuclear pore insertion impacts heart repair and regeneration, (PI, effort 5%), 2018-2020, $75,000
When do humans stop generating heart muscle cells?, (PI, effort 5%), 2019-2020, $25,000
Targeting an inhibitor of heart regeneration, (PI, effort 5%), 2018-2020, $47,000