Brian T. Campfield, MD
- Assistant Professor of Pediatrics
- Scholar, Richard King Mellon Foundation Institute for Pediatric Research
Brian T. Campfield joined the division as Assistant Professor of Pediatrics in 2014, providing subspecialty patient care and conducting research investigating the role of follistatin-like protein 1 (FSTL-1) in host defense and homeostasis in the lung, with a focus on innate immune responses and their impact on adaptive immunity. His lab employs multiple approaches including in vitro and in vivo animal models of sterile inflammation as well as bacterial pneumonia and viral infection. His lab is supported by funding from the NIH, the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh.
Campfield is a graduate of the University of Virginia and the University of Pittsburgh School of Medicine. He completed his Pediatrics residency and Pediatric Infectious Diseases fellowship at the Children’s Hospital of Pittsburgh of UPMC/University of Pittsburgh.
As a clinical subspecialist in Pediatric Infectious Diseases, Campfield provides care for inpatients and outpatients with a wide variety of complex infectious disease issues. His areas of interest include diagnosis and care of infectious complications in immunocompromised patients, including primary immunodeficiency and organ transplant recipients, patients with critical illnesses due to infectious diseases as well as children with Lyme disease.
Education & Training
- BA, Biology, University of Virginia, 2002
- MD, University of Pittsburgh School of Medicine, 2006
Campfield BT, Nolder CL, Davis A, Hirsch R, Nowalk AJ. The DBA/1 Strain is a Novel Mouse Model for Experimental Borrelia burgdorferi Infection. Clin Vaccine Immunol. 2012 Oct. PMID 22855391. PMCID PMC3485876.
Campfield BT, Nolder CL, Davis A, Bushnell D, Marinov A, Hirsch R, Nowalk AJ. Follistatin-like Protein 1 is a Critical Mediator of Experimental Lyme Arthritis and the Humoral Response to Borrelia burgdorferi Infection. Microb Pathog 2014. PMID 24768929. PMCID: PMC4899828.
Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield BT, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R. Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages. Eur J Immunol. 2014 Jan 28. PMID 24470197. PMCID PMC4004659.
Chaly Y, Blair HC, Smith S, Bushnell D, Marinov A, Campfield BT, Hirsch R. Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells. Ann Rheum Dis 2014 Mar 21. PMID 2461944.
Eddens T, Elsegeiny W, Nelson MP, Horne W, Campfield BT, Steele C, Kolls JK. Eosinophils Contribute to Early Clearance of Pnseumocystis murina Infection. J Immunol. 2015 May 20 PMID 25994969 PMCID: PMC4475669
Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK A Novel CD4+ T-cell Dependent Murine Model of Pneumocystis Driven Asthma-like Pathology. Am J Respir Crit Care Med. 2016 Oct 1 PMID: 27007260 PMCID: PMC5074654
Chen K, Campfield BT, Wenzel SE, McAleer JP, Kreindler JL, Kurland G, Gopal R, Wang T, Chen W, Eddens T, Quinn K, Myerburg MM, Horne WT, Lora JM, Albrecht BK, Pilewski JM, Kolls JK. Antiinflammatory Effects of Bromodomain and Extraterminal Domain Inhibition in Cystic Fribrosis Lung Inflammation. JCI Insight 2016 Jul 21; 1(11). PMID: 27517095. PMCID: PMC4978187. DOI: 10.1172/jci.insight.87168
Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016. PMID: 28355561 PMCID: PMC5411079
Campfield BT*, Eddens T, Henkel M, Majewski M, Horne W, Chaly Y, Gaffen SL, Hirsch R, Kolls JK. Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells. Immunol Cell Biol. 2017 Sep;95(8):656-665. PMID: 28377613 PMCID: PMC5609702 DOI 10.1038/icb.2017.26.
Eddens T, Kaplan DJ, Anderson AJM, Nowalk AJ, Campfield BT*. Insights from the Geographic Spread of the Lyme Disease Epidemic. Clin Infect Dis. 2019 Jan 18;68(3):426-434. 16 doi:10.1093/cid/ciy510 PMID: 29920580 PMCID: PMC6336907
Academic and Research Interests
- Host-Pathogen interactions in the lung
- The role of Follistatin-like protein 1 in lung inflammation