Brian Campfield, MD, is an Assistant Professor of Pediatrics at the University of Pittsburgh School of Medicine, within the Department of Pediatrics and Division of Infectious Diseases. After completing his undergraduate degree at the University of Virginia, he received his medical degree from the University of Pittsburgh School of Medicine in 2006. He then completed a pediatric residency in 2009 and pediatric infectious diseases fellowship in 2012 at Children's Hospital of Pittsburgh of UPMC. He then joined the faculty of the University of Pittsburgh School of Medicine with a clinical practice in pediatric infectious diseases and a research focus on novel mechanisms of inflammation and host-pathogen interaction.
His research is supported by NIH institutional and K08 funding as well as Children’s Hospital, centering on the role of Follistatin-like protein 1 in mediating inflammation and immunity, specifically in lung disease and innate and adaptive immunity. In addition to his research, Dr. Campfield continues to teach first and second-year students in the University of Pittsburgh School of Medicine as a problem-based learning group leader, as well as a faculty advisor for medical students, residents, and fellows in the Department of Pediatrics.
As a clinical specialist in Pediatric Infectious Diseases, Dr. Campfield provides care for inpatients and outpatients with a wide variety of complex infectious disease issues. His areas of interest include diagnosis and care of pediatric Lyme disease cases, and infectious complications in immunocompromised patients, including primary immunodeficiency and organ transplant recipients.
Major Lectureships and Seminars
- “A Follistatin-like Protein 1 Puzzle: IL-17, Inflammation and the Lung.” Child Health Research Center (K12) 10th Annual Retreat. Children’s Hospital of Pittsburgh. Pittsburgh, Pa., April 20, 2017
- “Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells.” Immunology 2017. Washington, D.C. May 15, 2017
Professional Affiliations/Society Memberships
- Fellow, American Academy of Pediatrics
- Infectious Diseases Society of America
- Pediatric Infectious Diseases Society
- American Association of Immunology
- American Thoracic Society
- American Association for the Advancement of Science
Education & Training
- Residency: University of Pittsburgh School of Medicine
- Fellowship: University of Pittsburgh School of Medicine
Brian T. Campfield joined the division as Assistant Professor of Pediatrics in 2014, providing patient care and conducting research investigating the role of follistatin-like protein 1 (FSTL-1) in host defense and immunity centered on the role of FSTL-1 in the lung.
Campfield is a graduate of the University of Virginia and completed medical school at the University of Pittsburgh School of Medicine. He completed his pediatrics residency and pediatric infectious diseases fellowship at the Children’s Hospital of Pittsburgh of UPMC/University of Pittsburgh. During fellowship, he reported the first study of FSTL-1 in response to infection in the murine model of Lyme disease. Subsequently, under the mentorship of Jay Kolls, he identified a novel and critical role for FSTL-1 in lung homeostasis. This work is the basis of his NIH K08 Career Development Award that was funded in 2015.
The Campfield laboratory focuses on host-pathogen interaction in the lung viewed through the lens of FSTL-1 function with a focus on innate and adaptive immune responses. His lab has identified a role for FSTL-1 in regulation IL17 signaling pathways.
A Critical Role for FSTL-1 in Lung Homeostasis. This work aims to investigate the temporospatial expression of FSTL-1 in the lung and the effect of FSTL-1 loss in a murine model of lung inflammation and emphysema development. This study additionally aims to examine the role of interleukin 17RA and CCR2 signaling in FSTL-1-dependent lung disease. A further aim of this research is to determine whether the role of FSTL-1 in lung homeostasis is intrinsic to lung tissue or due to circulating FSTL-1 protein. Through this Career Development Award, Campfield receives mentorship from John V. Williams, Steven D. Shapiro, Prabir Ray and Jay Kolls. Additional studies underway are investigating the role of FSTL-1 in acute lung injury utilizing novel tools developed in his lab to identify FSTL-1 function at the cellular level. This research is funded through the spring of 2020.
Mechanisms of FSTL-1 mediated inflammatory signaling. Cellular signaling pathways of FSTL-1 mediated inflammation are largely unknown. Campfield has developed several in vitro systems to assess the role of FSTL-1 in cellular signaling employing genetic and molecular suppression, overexpression, and tagged-expression. These studies have identified a novel function for FSTL-1 as a modulator of transcriptional regulation.
- Molecular Basis of Pediatric Disease
- Host-Pathogen interactions in the lung
- Lyme Disease and host-pathogen interactions in Borrelia burgdorferi infection