Carlton M. Bates, M.D.

  • Chief, Division of Nephrology 
  • Professor of Pediatrics
  • Vice Chair of Basic Research

Major Lectureships and Seminars

  • “Renal and Urogenital Development and Their Developmental Abnormalities,” Developmental Renal Malformations, Oligo/Anhydramnios: Pathophysiology and Clinical Aspects, NICHD Workshop, Bethesda, MD, Aug 9, 2016.
  • “From Tubes to Cysts: Novel Mechanisms Driving Pathology in Cystic Kidney Disease,” 17th Congress of the International Pediatric Nephrology Association, Iguassu Falls, Brazil, September 24, 2016
  • “From Tubes to Cysts: Novel Mechanisms Driving Pathology in Cystic Kidney Disease,” UCLA Pediatric Nephrology Grand Rounds, Los Angeles, CA, October 21, 2016
  • “Fgfr Signaling in Nephron Progenitors: Links to Metabolism and Cystogenesis,” Renal Grand Rounds at Cincinnati Children’s Medical Center, Cincinnati, OH, March 16, 2017.
  • “Fgfr signaling in nephron progenitors: Links to metabolism and cystogenesis,” O’Brien Center lecture, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, October 2, 2017
  • “Fgfr signaling in nephron progenitors: Links to metabolism and cystogenesis’ RenalTract Conference, University of Manchester, Manchester, UK, April 13, 2018. 

Professional Affiliations/Society Memberships

  • American Pediatric Society
  • American Physiological Society
  • American Society for Clinical Investigation
  • American Society of Nephrology
  • American Society of Pediatric Nephrology
  • International Society of Nephrology
  • International Pediatric Nephrology Association
  • National Kidney Foundation
  • Salt and Water Club
  • Society for Pediatric Research

Study Sections

  • Basil O’Conner Research Advisory Committee, March of Dimes
  • Urologic and Hematologic Diseases D Subcommittee (reviewing training [T32, T35] and career development [K01, K08, K23, K24, K00, R25, R03] applications), NIDDK, NIH

Education & Training

  • MD: The Ohio State University Columbus, OH
  • Residency: The Ohio State University Columbus, OH
  • Fellowships: University of Texas Southwestern Medical Center Dallas, TX

Representative Publications

A list of publication by Dr. Bates can be found at the NCBI Collection

Research Interests

Carlton Bates conducted NIH-funded studies on the role of fibroblast growth factor receptors (Fgfrs) and their signaling adapter proteins in the developing kidney and lower urinary tract using the mouse as a model. These studies are clinically relevant given that congenital abnormalities of the kidney and urinary tract are responsible for the majority of cases of chronic kidney disease in children. Using various gene-targeting approaches, the laboratory revealed how Fgfrs and their adapters are critical for temporal patterning of multiple renal and bladder tissue lineages. They generated mouse models of pediatric structural kidney and lower urinary diseases, including obstructive nephropathy, renal aplasia/dysplasia/hypoplasia, vesicoureteral reflux and reflux nephropathy, progressive cystic kidney disease, atonic bladders, and functional bladder obstruction. The laboratory continued to elucidate the molecular pathways through which Fgfrs pattern developing bladder urothelium and repair postnatal urothelium after injury. The lab recently discovered novel critical links between Fgfr signaling and glucose metabolism in developing nephron progenitors. These approaches may lead to new biomarkers and therapeutic targets for congenital kidney and lower urinary tract disease.

Division

Lab