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Danica M. Sutherland, PhD
- Research Instructor
- Lab Manager, The Dermody Lab
Dr. Sutherland learned from an early age, "if you want to tell a story, start from the beginning". Her research interests follow suite and focus on the initial step of the viral replication cycle. She is particularly interested in how virus:receptor interactions dictate species and tissue tropism in the brain. Her research spans from collaborative structural studies to receptor characterization in cultured primary and transformed cells to studying how receptor use influences reovirus pathogenesis in a mouse model. Dr. Sutherland also functions as the lab manager and a senior mentor within the Dermody lab.
Education & Training
- BS, University of Tulsa, 2001
- PhD, Vanderbilt University, 2018
Selected Publications
Fites JS, Ramsey JP, Holden WM, Collier SP, Sutherland DM, Reinert LK, Gayek AS, Dermody TS, Aune TM, Oswald-Richter K, Rollins-Smith LA. 2013. The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science. 342:6156.
Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS. 2014. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 15:6.
Research Highlighted: Kåhrström CT. 2014. Neural receptor for reovirus revealed. Nature Rev Micro. 12:532.
Dietrich MH, Ogden KM, Katen SP, Reiss K, Sutherland DM, Carnahan RH, Goff M, Cooper T, Dermody TS, Stehle T. 2017. Structural insights into reovirus σ1 interactions with two neutralizing antibodies. J Virol. 91:4.
Wu AG, Pruijssers AJ, Brown JJ, Stencel-Baerenwald JE, Sutherland DM, Iskarpatyoti JA, Dermody TS. 2018. Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response. Pediatr Res. 83:5.
Sutherland DM, Aravamudhan P, Dermody TS. 2018. An orchestra of reovirus receptors: Still searching for the conductor. Adv. Virus Res. 100:223.
Sutherland DM, Aravamudhan P, Dietrich MH, Stehle T, Dermody TS. 2018. Reovirus neurotropism and virulence are dictated by sequences in the head domain of the viral attachment protein. J Virol. 92:23.
Tenorio R, Fernandez de Castro I, Knowlton JJ, Zamora PF, Sutherland DM, Risco C, Dermody TS. 2019. Function, architecture, and biogenesis of reovirus replication neorganelles. Viruses. 11:288.
Aravamudhan P, Raghunathan K, Konopka-Anstadt J, Pathak A, Sutherland DM, Carter BD, Dermody TS. 2020. Reovirus uses micropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS Path. 16:2.
Sutherland DM, Taylor GM, Dermody TS. 2020. Coping with COVID: How a research team learned to stay engaged in this time of physical distancing. mBio. 11:2.