Daniel J. Weiner, MD, FAAP, FCCP, ATSF

  • Professor of Pediatrics
  • Director, Antonio J. and Janet Palumbo Cystic Fibrosis Center, UPMC Children's Hospital of Pittsburgh
  • Director, Pulmonary Function & Exercise Laboratories, UPMC Children's Hospital of Pittsburgh

Daniel Weiner, MD is a Professor of Pediatrics and Pediatric Pulmonologist at Children's Hospital of Pittsburgh. His clinical interests are cystic fibrosis and pulmonary function testing in infants and children. His research interests include pulmonary complications of chemotherapy/radiotherapy for cancer and applications of novel pulmonary function tests.

Professional and Scientific Society Memberships

  • Alpha Omega Alpha, 1992-Present
  • Physicians for Social Responsibility, 1993-Present
  • American Thoracic Society, Member, 1997-Present
  • European Respiratory Society, Associate Member, 1997-Present
  • American College of Chest Physicians, Affiliate Member, 1997-2001
  • American Academy of Pediatrics, Fellow, 1998-Present
  • American College of Chest Physicians, Fellow, 2001-Present
  • Association for Respiratory Technology & Physiology, 2010-2012
  • American Physiologic Society, Member, 2011-Present
  • American Thoracic Society, Fellow, 2018-Present

Education & Training

  • BS, Biomedical Sciences, University of Michigan, 1990
  • MD, University of Michigan School of Medicine, 1993
  • House Officer in Pediatrics, University of Michigan Hospitals, 1993-1995
  • House Officer in Pediatrics, Thomas Jefferson University Hospital, 1995-1996
  • Fellow in Pediatrics and Pulmonology, St. Christopher’s Hospital for Children, 1996-1998
  • Research Fellow, Institute for Human Gene Therapy, University of Pennsylvania, 1996-2003
  • Fellow in Pediatrics and Pulmonology, The Children’s Hospital of Philadelphia, 1998-1999

Selected Publications

Glycemic control and FEV1 recovery during pulmonary exacerbations in pediatric cystic fibrosis-related diabetes. Okoniewski W, Hughan KS, Weiner GA , Weiner DJ, Forno E. in press, Journal of Cystic Fibrosis, January 2020. https://doi.org/10.1016/j.jcf.2019.12.016 PMID 31980357

Khan F, Williams AM, Weiner DJ, Constine LS. The Impact of Respiratory Developmental Stage on Sensitivity to Late Effects of Radiation in Pediatric Cancer Survivors. In Press, Advances in Radiation Oncology, December 2019. DOI: https://doi.org/10.1016/j.adro.2019.12.002

Weiner GA, Forno E, Weiner DJ. The effects of high-frequency chest compression on end-tidal CO2. Pediatr Pulmonol. 2019 Nov 25. doi: 10.1002/ppul.24588. PMID: 31765524

Singh A, Feingold B, Rivera-Lebron B, Weiner D, Drant S. Correlating Objective Echocardiographic Parameters in Patients with Pulmonary Hypertension due to Bronchopulmonary Dysplasia." J Perinatol. 2019 Jul 16. doi: 10.1038/s41372-019-0429-3. PMID: 31312036

Corcoran TE, Saville A, Adams PS, Johnston DJ, Czachowski MR, Domnina YA, Lin JH, Weiner DJ, Huber AS, Sanchez De Toledo J, Lo CW. Deposition studies of aerosol delivery by nasal cannula to infants. Pediatr Pulmonol. 2019 Apr 1. doi: 10.1002/ppul.24326. PMID: 3093234

Corcoran TE, Huber AS, Myerburg MM, Weiner DJ, Locke LW, Lacy RT, Weber L, Czachowski MR, Johnston DJ, Muthukrishnan A, Lennox AT, Pilewski JM. Multiprobe Nuclear Imaging of the Cystic Fibrosis Lung as a Biomarker of Therapeutic Effect. J Aerosol Med Pulm Drug Deliv. 2019 Apr 10. doi: 10.1089/jamp.2018.1491. PMID: 3096914

Guglani L, Kasi A, Starks M, Pedersen KE, Nielsen JG, Weiner DJ. Difference between SF6 and N2 Multiple Breath Washout kinetics is Due to N2 back Diffusion and Error in N2 Offset. J Appl Physiol (1985). 2018 Jul 26. doi: 10.1152/japplphysiol.00326.2018. PMID: 30048204

Michel H, Al-Quatarneh S, Venkat V, Lindblad D, Ozolek, John, Weiner DJ. Pancreatic cystosis and intrahepatic biliopathy in a young adult with cystic fibrosis. J Pediatr. 2018 Jul 2. pii: S0022-3476(18)30767-4. doi: 10.1016/j.jpeds.2018.05.054. PMID: 30041939

Forno E, Abraham N, Kurland G, Rosas-Salazar C, Winger D, Weiner DJ. Perception of Pulmonary Function in Children with Asthma and Cystic Fibrosis. Pediatr Allergy Immunol Pulmonol. 2018 Sep 1;31(3):139-145. doi: 10.1089/ped.2018.0906. Epub 2018 Sep 17. PMID: 30283712

Sommerfeld C, Nowalk A, Lark A, Weiner DJ. Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome from E-Cigarette Use. Pediatrics. 2018 Jun;141(6). pii: e20163927. doi: 10.1542/peds.2016-3927. Epub 2018 May 17. PMID: 29773665

Full Publication List via NIH PubMed »

Academic and Research Interests

  • Cystic Fibrosis
  • Pulmonary Physiology

Research Grants

CF Center Clinical Operations Grant, 2018-2019, $220,140

A Long-Term Prospective Observational Safety Study of the Incidence of and Risk Factors for Fibrosing Colonopathy in US Patients with Cystic Fibrosis Treated with Pancreatic Enzyme Replacement Therapy: A Harmonized Protocol Across Sponsors, 2012-2022, $30,631

Peak Cough Flow and Airway Clearance in Neuromuscular Disease, 2013-2019, $70,000

CFF Research & Development Program, Basic and Translational Studies of Cystic Fibrosis Core B, (PI, effort 5%), 2015-2020, $186,283

GRANT11766462, Respiratory Ciliary Dysfunction and Pulmonary Risks in Congenital Heart Disease Patients, (PI, effort 5%), 2015-2018, $1,631,769

A Long-Term Prospective Observational Safety Study of the Incidence of and Risk Factors for Fibrosing Colonopathy in US Patients with Cystic Fibrosis Treated with Pancreatic Enzyme Replacement Therapy: A Harmonized Protocol Across Sponsors, 2012-2022, $30,631

HORSLE17A0, Longitudinal change in lung clearance index (LCI) in infants, 2018-2020

WEIN00, Barriers to Lung Directed Gene Therapy with AAV (CFF Harry Schwachman Clinical Investigator Award), (PI, effort 80%), 2000-2003, $225,000

RUBENS01A0, Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis); CFF Pilot/Feasibility Study (clinical trials.gov NCT00016744),(PI, effort 5%) 2001-2003, $160,000

5M01RR000240-40, Non-Invasive Assessment Of Respiratory Muscle Fatigue, (PI, effort 5%), 2005-2006