Dr. Yimlamai is a physician-scientist trained as a clinical gastroenterologist with a special interest in pediatric liver diseases and liver tumors. In his lab, his group uses muine model organisms to understand the fundamental mechanisms of liver growth during development, its restoration from injury and changes that lead to oncogenesis.
Education & Training
- MD: Tufts University School of Medicine Boston, MA
- Residency: Boston Children's Hospital Boston, MA
- Fellowships: Boston Children's Hospital Boston, MA
Cox, A.G.*, Hwang, K.L.*, Evason, K., Brown, K.K., Beltz, S., O’Connor, K., Galli, G.G., Tsomides, A., Yimlamai, D., Chhangawala, S., Yuan, M, Lien, E., Wucherpfennig, J., Nissim, S., Minami, A., Cohen, D.E., Camargo, F.D., Asara, J., Houvras, Y., Stainier, D.Y., Goessling, W. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature Cell Biology. 2016; 18:886–896. PMID: 27428308.
Patel, S.H., Camargo, F.D., Yimlamai, D. Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis. Gastroenterology. 2017; 152:533-545. PMID: 28003097.
Leung, D. and Yimlamai, D. The intestinal microbiome and paediatric liver disease. The Lancet Gastroenterology and Hepatology. 2017; 2(6):446-455. PMID: 28497760.
- Characterize the roles that liver cell sub-types play in the development of liver inflammation and fibrosis with respect to the Hippo Signaling pathway.
- Investigate the determinants of hepatocyte heterogeneity and their contribution to metabolic disease, liver regeneration and oncogenesis.
- Determine the mechanistic differences that sex plays in affecting the liver’s metabolic and regenerative response.
Up-to-date details on Dean Yimlamai research can be found at Pittsburgh Liver Research Center.
|1 K08 DK10535||Yimlamai (PI)||
1 - NIDDK Hippo Signaling Mediates Liver Fibrosis Development
The Aims of this proposal are to 1) Determine if Fibrogenic Liver Injury Inactivates Epithelial Hippo signaling, 2) Identify the Critical Fibrogenic Factors Epithelial Cells Generate in Response to Hippo Signaling Inhibition, and, 3) Explore the Biochemical/Cellular Crosstalk that Results in Hepatic Fibrosis