Edward H. Hurley, MD

  • Assistant Professor of Pediatrics

Hurley first encountered both basic research and neonatology occurred early in medical school after spending the summer between first and second year conducting research on biomarkers for bronchopulmonary dysplasia in the lab of Lance Parton, MD, a neonatologist. This work was presented at both regional and national meetings. During residency, Hurley committed to a career in neonatology. He stayed at Brown University for neonatology fellowship where he developed an interested in liver research while working with Philip Gruppuso, MD. During fellowship he was elected President of the Society for Pediatric Research’s junior section. He chose to accept a faculty position at the University of Pittsburgh for the opportunity to work with Satdarshan (Paul) Monga, MD, the director of the Pittsburgh Liver Research Center, which recently was named one of the 20 NIDDK-designated Digestive Disease Research Core.

In the Monga lab, Hurley is investigating how modulating signaling from heat shock factor 1 impacts the development of hepatoblastoma, the most common liver cancer in children and is often seen in kids who were born small or premature. Recently, Hurley was elected a councilor for the Society for Pediatric Research and was elected as a finalist for the society’s young faculty award.

Professional and Scientific Society Memberships

  • United States Developmental Origins of Health and Disease Society, 2019-Present 
  • Eastern Society for Pediatric Research, 2018-Present 
  • Society for Pediatric Research, 2015-Present 
  • American Academy of Pediatrics, 2012-Present 

Education & Training

  • BA, Journalism/Philosophy, University of Massachusetts, 1997
  • MD, New York Medical College, 2012
  • Residency in Pediatrics, Brown University, 2012-2015
  • Fellowship in Neonatology, Brown University, 2015-2018

Selected Publications

Hurley EH, Gruppuso PA, Sanders JA. In-utero nutrient deprivation induces sex-specific changes in neonatal liver gene expression. In preparation. 

Hurley E, Zabala V, Boylan JM, Gruppuso PA, Sanders JA. Hepatic Gene Expression during the Perinatal Transition in the Rat. Gene Expr. 2018 Jun 21. PubMed PMID: 29929573. 

Hurley EH, Keszler M. Effect of inspiratory flow rate on the efficiency of carbon dioxide removal at tidal volumes below instrumental dead space. Arch Dis Child Fetal Neonatal Ed. 2017 Mar;102(2):F126-F130. PubMed PMID: 27515984. 

Hurley EH, Krishnan S, Parton LA, Dozor AJ. Differences in perspective on prognosis and treatment of children with trisomy 18. Am J Med Genet A. 2014 Oct;164A(10):2551-6. PubMed PMID: 25098974.

Full Publication List via NIH PubMed »

Academic and Research Interests

  • Role of β-catenin signaling in the development of nonalcoholic fatty liver disease
  • Differential role of β-catenin signaling in the development of nonalcoholic fatty liver disease in children and adults
  • Role of heat shock factor 1 (HSF1) in the pathogenesis of hepatoblastoma