Eric N. Anderson, PhD

Anderson EN, Morera A, Kour S, Cherry JD, Ramesh N, Gleixner A, Schwartz J, Ebmeier C, Old W, Donnelly CJ, Cheng JP, Kline AE, Stein T, Pandey UB. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Elife, 2021, 10: e67587. doi: 10.7554/eLife.67587.

Lin Y-C#, Kumar MS#, Ramesh N#, #, Anderson EN, Nguyen AT, Kim B, Cheung S, McDonough JA, Skarnes WC, Lopez-Gonzalez R, Landers JE, Fawzi NL, Mackenzie IRA, Lee EB, Nickerson JA, Grunwald D, Pandey UB, Bosco DA. Interaction between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature Neurosci, 2021. doi: 10.1038/s41593-021-00859-9. #Contributed equally

Fortuna TR, Kour S, Anderson EN, Ward C, Rajasundaram D, Donnelly CJ, Hermann A, Wyne H, Shewmaker F, Pandey UB. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Acta Neuropathol, 2021. doi: 10.1007/s00401-021-02333-z

Kour S, Rajan DS , Fortuna TR , Anderson EN , Ward C , Lee Y , Lee S , Shin YB , Chae J-H , Choi M, Siquier K , Cantagre V , Amiel J , Stolerman ES , Barnett SS , Cousin MA , Castro D, McDonald K, Kirmse B, Nemeth AH , Rajasundaram D, Innes M, Lynch D, Frosk P, Collins A , Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C , Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Verdura E, Pujol A, McCurry HR, Landers JE, Agnihotri S, Andriescu EC, Moody SB, Phornphutkul C , Sacoto MJG, Begtrup A, Houlden H, Kirschner J, Schorling D, Rudnik-Schöneborn S, Strom TM, Leiz S, Juliette K, Richardson R, Platzer K, Donkervoort S, Bönnemann CG, Wagner M, Issa Y, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB. Loss of Function mutations in GEMIN5 cause a neurodevelopmental disorder. Nature Commun, 2021, 12. 2558. https://doi.org/10.1038/s41467-021-22627-w

García-Cazorla A*, Verdura E*, Juliá-Palacios N, Anderson EN, Goicoechea L, Planas-Serra L, Tsogtbaatar E, Dsouza NR, Schlüter A, Urreizti R, Tarnowski JM, Ralitza GH, Gavrilova RH, SHMT2 Working Group, Ruiz M, Rodríguez-Palmero A, Fourcade S, Cogné B, Besnard T, Vincent M, Bézieau S, Fourcade S, Folmes CD, Zimmermann MT, Klee EW, Pandey UB, Artuch R, Cousin MA, Pujol A. Impairment of mitochondrial one-carbon folate enzyme SHMT2 causes a novel brain and heart developmental syndrome. Acta Neuropathol. 2020, 140: 971-975. *Contributed equally

Migazzi A#, Scaramuzzino C#, Anderson EN, Tripathy D, Hernández HI, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross AC, Pandey U, Lucas JJ, Saudou F, Pennuto M, Basso M. Axonal transport by Huntingtin requires arginine methylation by PRMT6. Cell Reports. In Press

Ramesh N, Kour S, Anderson EN, Rajasundaram D, Pandey UB. RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Acta Neuropathol Commun. 2020, 8: 138. 

Ramesh N, Daley EL, Mann J, Gleixner, AM, Kour S, Darilang M, Anderson EN, Kofler J, Donnelly CJ, Kiskinis E, Pandey UB. RNA-dependent suppression of C90rf72 neurodegeneration by Matrin 3. Acta Neuropathol Commun. In Press

Anderson EN, Hirpa D, Zheng HK, Banerjee R, Gunawardena S. The non-amyloidal component region (NAC) of α-Synuclein is important for α-synuclein transport within axons: Front. Cell. Neurosci. 2020, 13:540.

Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A,  and Sterneckert J, FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy: Acta Neuropathologica. 2019, 138: 67-84 

Casci I*, Krishnamurthy K*, Kour S*, Ramesh N, Anderson EN, Oliver S, Grant R, Gochenaur L, Patel K, Tripathy V, Marrone L, Sterneckert J, Gleixner A, Donnelly C, Ruepp MD, Pasinelli P, Pandey UB. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Nature Commun. 2019, 10: 5583. 

Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, and Sterneckert J, Dual Inhibition of GSK3 and CDK5 protects the cytoskeleton of neurons from neuroinflammatory-mediated degeneration in vitro  and in vivo: Stem Cell Reports. 2019, 12: 502-517.

Anderson EN, Gochenaur L, Singh A, Grant R, Patel K, Watkins S, Wu JY and, Pandey UB, Traumatic injury induces Stress Granule Formation and enhances Motor Dysfunctions in ALS Models. Hum Mol Genet, 2018, 27: 1366-1381.

Bakthavachalu B, Huelsmeier J, Sudhakaran IP, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoe L, Anderson EN, Pandey UB, Ross E, VijayRaghavan K, Parker R, and Ramaswami M. RNP-Granules assembly via ATAXIN-2 disordered domains is required for long-term memory and neurodegeneration. Neuron, 2018, 98: 754-766.  *Previewed in ‘Neuron’

White JA, Anderson E, Zimmerman K, Zheng KH, Rouhani R, Gunawardena S. Huntingtindifferentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. Hum MolGenet. 2015, 20: 7182-95. 1contributed equally

Anderson EN, White JA II, Gunawardena S. Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation. Degenerative Neurological and NeuromuscularDisease, 2014, 4: 29-47