Eric S. Goetzman, PhD

  • Associate Professor of Pediatrics

Eric Goetzman is an associate professor of pediatrics at the University of Pittsburgh School of Medicine in the Division of Genetic and Genomic Medicine. He also holds a secondary appointment in the Department of Genetics at the University of Pittsburgh School of Public Health. Goetzman received his Bachelor of Arts degree from the University of Minnesota-Morris and his Doctor of Philosophy degree from the University of Alabama-Birmingham. He completed two years of post-doctoral research at the Mayo Clinic before moving to Pittsburgh in 2004. Following completion of his training he joined the faculty of the Department of Pediatrics in 2006. Goetzman’s research interests are in the areas of metabolism and mitochondrial function, with a specific focus on fat metabolism. His research has enhanced our understanding of how post-translational modifications of metabolic enzymes controls their activity and function. He has published more than 60 articles, reviews, and chapters in this area and related topics.

Professional and Scientific Society Memberships

  • American Society of Human Genetics, 2004-2007
  • American Diabetes Association, 2006-2007
  • Society for Inherited Metabolic Disorders, 2006-2009, 2015-Present
  • Mitochondria, Aging, and Metabolism Working Group, 2010-2016
  • International Network for Fatty Acid Oxidation Disorders Research and Management, 2014-Present
  • Gm3 Working Group, 2016-Present
  • Pittsburgh Liver Center, 2016-Present
  • Pittsburgh Center for Metabolism & Mitochondrial Medicine, 2018-Present

Education & Training

  • BS, Psychology/Pre-Med, University of Minnesota-Morris, 1994
  • PhD, Medical Genetics, University of Alabama-Birmingham, 2002
  • Postdoctoral Fellowship, Mayo Clinic, 2002-2004
  • Postdoctoral Fellowship, UPMC Children's Hospital of Pittsburgh, 2004-2006

Selected Publications

Zhang Y, Bharathi SS, Beck ME, Goetzman ES. The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol. 2019.

Gong Z, Zhang X, Su K, Jiang R, Sun Z, Chen W, Forno E, Goetzman ES, Wang J, Dong HH, Dutta P, Muzumdar R. Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance. Diabetologia. 2019 Sep 11. PMID: 31511929.

Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES*, Sims-Lucas S*. Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. J Am Soc Nephrol. 2019 Oct 1. *Co-corresponding authors

Beck ME, Zhang Y, Bharathi SS, Kosmider B, Bahmed K, Dahmer MK, Nogee LM, Goetzman ES. The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function. Mol Genet Metab. 2020 May 1;S1096-7192(20)30111-6.

Sharp TE, Gong Z, Scarborough A, Goetzman ES, Ali MJ, Spaletra P, Lefer DJ, Muzumdar RH, Goodchild TT. Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury. JACC Basic Transl Sci. 2020 Jun 17;5(7):699-714. doi: 10.1016/j.jacbts.2020.04.015. PMID: 32760857; PMCID: PMC7393416.

Bharathi SS, Zhang Y, Gong Z, Muzumdar R, Goetzman ES. Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids. Biochem Biophys Res Commun. 2020 Jun 18;527(1):162-166. doi: 10.1016/j.bbrc.2020.04.105. PMID: 32446361; PMCID: PMC7248122.

Goetzman ES, Bharathi SS, Zhang Y, Zhao XJ, Dobrowolski SF, Peasley K, Sims-Lucas S, Monga SP. Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice. Sci Rep. 2020 Oct 27;10(1):18367. doi: 10.1038/s41598-020-75615-3. PMID: 33110171.

Wang H, Lu J, Chen X, Schwalbe M, Gorka JE, Mandel JA, Wang J, Goetzman ES, Ranganathan S, Dobrowolski SF, Prochownik EV. Acquired Deficiency of Peroxisomal Dicarboxylic Acid Catabolism is a Metabolic Vulnerability in Hepatoblastoma. J Biol Chem. 2021 Jan 12:100283. doi: 10.1016/j.jbc.2021.100283. PMID: 33450224.

Dobrowolski SF, Sudano C, Phua YL, Tourkova IL, Spridik K, Goetzman ES, Vockley J, Blair HC. Mesenchymal stem cell energy deficit and oxidative stress contribute to osteopenia in the Pahenu2 classical PKU mouse. Mol Genet Metab. 2021 Feb 11:S1096-7192(21)00034-2. doi: 10.1016/j.ymgme.2021.01.014. PMID: 33602601.

Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM. Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res. 2021 Mar 20:100069. doi: 10.1016/j.jlr.2021.100069. Epub ahead of print. PMID: 33757734.

Dobrowolski SF, Sudano C, Phua YL, Tourkova IL, Spridik K, Goetzman ES, Vockley J, Blair HC. Mesenchymal stem cell energy deficit and oxidative stress contribute to osteopenia in the Pahenu2 classical PKU mouse. Mol Genet Metab. 2021 Mar;132(3):173-179. doi: 10.1016/j.ymgme.2021.01.014. Epub 2021 Feb 11. PMID: 33602601.

Full Publication List via NIH PubMed »

Academic and Research Interests

  • Metabolism
  • Mitochondria
  • Peroxisomes
  • Fatty Acid Oxidation

Research Grants

NIH R01DK090242, Regulation of Mitochondrial Metabolism by Lysine Acylation (PI, 70% effort), 2016-2021, $1,479,000.

NIH R21HD097403, Ganglioside Replacement Therapy for GM3 Synthase Deficiency (PI, 10% effort), 2019-2021.