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Eric S. Goetzman, PhD

  • Associate Professor of Pediatrics

Eric Goetzman is an associate professor of pediatrics at the University of Pittsburgh School of Medicine in the Division of Genetic and Genomic Medicine. He also holds a secondary appointment in the Department of Genetics at the University of Pittsburgh School of Public Health. Goetzman received his Bachelor of Arts degree from the University of Minnesota-Morris and his Doctor of Philosophy degree from the University of Alabama-Birmingham. He completed two years of post-doctoral research at the Mayo Clinic before moving to Pittsburgh in 2004. Following completion of his training he joined the faculty of the Department of Pediatrics in 2006. Goetzman’s research interests are in the areas of metabolism and mitochondrial function, with a specific focus on fat metabolism. His research has enhanced our understanding of how post-translational modifications of metabolic enzymes controls their activity and function. His work is advancing the use of alternative dietary fats for the treatment of metabolic disorders. He has published more than 65 articles, reviews, and chapters in this area and related topics.

Professional and Scientific Society Memberships

  • American Society of Human Genetics, 2004-2007
  • American Diabetes Association, 2006-2007
  • Society for Inherited Metabolic Disorders, 2006-2009, 2015-Present
  • Mitochondria, Aging, and Metabolism Working Group, 2010-2016
  • International Network for Fatty Acid Oxidation Disorders Research and Management, 2014-Present
  • Gm3 Working Group, 2016-Present
  • Pittsburgh Liver Center, 2016-Present
  • Pittsburgh Center for Metabolism & Mitochondrial Medicine, 2018-Present

Education & Training

  • BS, Psychology/Pre-Med, University of Minnesota-Morris, 1994
  • PhD, Medical Genetics, University of Alabama-Birmingham, 2002
  • Postdoctoral Fellowship, Mayo Clinic, 2002-2004
  • Postdoctoral Fellowship, UPMC Children's Hospital of Pittsburgh, 2004-2006

Selected Publications

Goetzman ES, Vockley J. Lysine acylation causes collateral damage in inborn errors of metabolism. Sci Transl Med. 2022 May 25;14(646). doi: 10.1126/scitranslmed.abq4863. PMID: 35613282.

Goetzman E, Gong Z, Rajasundaram D, Muzumdar I, Goodchild T, Lefer D, Muzumdar R. Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia-Reperfusion. Int J Mol Sci. 2022 Jun 16;23(12):6711. doi: 10.3390/ijms23126711. PMID: 35743153; PMCID: PMC9223436.

Bharathi SS, Zhang BB, Paul E, Zhang Y, Schmidt AV, Fowler B, Wu Y, Tiemeyer M, Inamori KI, Inokuchi JI, Goetzman ES. GM3 synthase deficiency increases brain glucose metabolism in mice. Mol Genet Metab. 2022 Oct 28;137(4):342-348. doi: 10.1016/j.ymgme.2022.10.006. PMID: 36335793.

Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R. Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys. Antioxidants (Basel). 2023 Apr 8;12(4):900. doi: 10.3390/antiox12040900. PMID: 37107275; PMCID: PMC10135478.

Rutledge C, Enriquez A, Redding K, Lopez M, Mullett S, Gelhaus SL, Jurczak M, Goetzman E, Kaufman BA. Liraglutide Protects Against Diastolic Dysfunction and Improves Ventricular Protein Translation. Cardiovasc Drugs Ther. 2023 Jun 29. doi: 10.1007/s10557-023-07482-9. Epub ahead of print. PMID: 37382868.

Rutledge CA, Lagranha C, Chiba T, Redding K, Stolz DB, Goetzman E, Sims-Lucas S, Kaufman BA. Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest. J Mol Cell Cardiol Plus. 2023 Jun; 4:100034. doi: 10.1016/j.jmccpl.2023.100034. Epub 2023 Apr 5. PMID: 37425219; PMCID: PMC10327679.

Goetzman E, Gong Z, Zhang B, Muzumdar R. Complex II Biology in Aging, Health, and Disease. Antioxidants (Basel). 2023 Jul 24;12(7):1477. doi: 10.3390/antiox12071477. PMID: 37508015; PMCID: PMC10376733.

Schmidt AV, Monga SP, Prochownik EV, Goetzman ES. A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma. Int J Mol Sci. 2023 Aug 9;24(16):12618. doi: 10.3390/ijms241612618. PMID: 37628798; PMCID: PMC10454864.

Burton JB, Silva-Barbosa A, Bons J, Rose J, Pfister K, Simona F, Gandhi T, Reiter L, Bernhardt O, Hunter CL, Goetzman ES, Sims-Lucas S, Schilling B. Substantial downregulation of mitochondrial and peroxisomal proteins during acute kidney injury revealed by data-independent acquisition proteomics. Proteomics. 2023 Sep 29:e2300162. doi: 10.1002/pmic.202300162. Epub ahead of print. PMID: 37775337.

Anne C. S. Barbosa, Katherine E. Pfister, Takuto Chiba, Joanna Bons, Jacob P. Rose, Jordan B. Burton, Christina D. King, Amy O’Broin, Victoria Young, Bob Zhang, Bharathi Sivakama, Alexandra V. Schmidt, Rebecca Uhlean, Birgit Schilling, Eric S. Goetzman**, Sunder Sims-Lucas**. Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity. J Am Soc Nephrol. 2023 In press.   

**Co-corresponding authors

Full Publication List via NIH PubMed »

Academic and Research Interests

  • Metabolism
  • Mitochondria
  • Peroxisomes
  • Inborn errors of metabolism

Research Grants

NIH R01 DK090242, Regulation of Peroxisomal Metabolism by Lysine Acylation, 06/11 – 05/25 

NIH R01 DK068196, Chaperone Actions in CFTR Biogenesis, 03/04 –03/25

NIH R01 HD103602, Optimizing medium-chain lipids for the treatment of long-chain fatty acid oxidation disorders, 03/21 – 02/26 

NIH R01 DK121758, The Role of Sirtuin 5 in Acute Kidney Injury, (Sunder Sims-Lucas, PI) 07/20 – 06/25

NIH R01 AG069399, Cardioprotective role of humanin in aging, (Radhika Muzumdar, PI), 05/21 – 05/26

NIH R21 NS121706, Bioenergetics and Neuronal Network Remodeling in a Rodent Model of Temporal Lobe Epilepsy,  01/22 – 01/24

United States DoD PR211767, 4D Oxy-Wavelet MRI as a Non-Invasive Biomarker of Brain Mitochondrial Function in Vivo, 07/22 – 06/27

Cystic Fibrosis Foundation, Novel Lung Targeting Peptides on Nanocarriers to Treat Cystic Fibrosis, 01/23 – 12/24