Evgeni Efimenko, PhD

  • Senior Research Specialist

Evgeni Efimenko, Ph.D., is a Senior Researcher at the department of Pediatrics. He has a Ph.D. from Karolinska Institute in Sweden, where he studied genetics and developmental biology. Before joining the University of Pittsburgh, Evgeni obtained postdoctoral training at the Medical University of South Carolina and Dartmouth College. After that, Evgeni joined the lab of Dr. Diacovo at Columbia University. His current research interests include genetics,cancer biology and drug development.

Education & Training

  • BS, Biology, Dniepropetrovsk State University, 2000
  • Specialist in Biology, Dniepropetrovsk State University, 2001
  • PhD, Medical Sciences, Karolinska Institute, 2008

Selected Publications

Efimenko, E., Davé, U. P., Lebedeva, I. V., Shen, Y., Sanchez‐Quintero, M. J., Diolaiti, D., Kung, A., Lannutti, B. J., Chen, J., Realubit, R., Niatsetskiya, Z., Ten, V., Karan, C., Chen, X., Califano, A. and Diacovo, T.G. (2017). PI3Kγ/δ and NOTCH1 cross‐regulate pathways that define the T‐cell acute lymphoblastic leukemia disease signature. Molecular Cancer Therapeutics 16 (10), 2069‐2082.

Subramaniam, P. S., Whye, D. W., Efimenko, E., Chen, J., Tosello, V., Keersmaecker, K., Kashishian, A., Thompson, M. A., Castillo, M., Cordon-Cardo, C., Dave, U. P., Ferrando, A., Lannutti, B. J. and Diacovo, T. G. (2012). Targeting nonclassical oncogenes for therapy in T-ALL. Cancer Cell 21, 459–472.

Efimenko, E., Padua, M. B., Manuylov, N. L., Fox, S. C., Morse, D. A. and Tevosian, S. G. (2013). The transcription factor GATA4 is required for follicular development and normal ovarian function. Developmental Biology 381, 144–158.

Zaytouni, T., Efimenko, E. and Tevosian, S. G. (2011). GATA transcription factors in the developing reproductive system. Advances in Genetics 76, 93-134.

Phirke, P., Efimenko, E., Mohan, S., Burghoorn, J., Crona, F., Bakhoum, M. W., Trieb, M., Schuske, K., Jorgensen, E. M., Piasecki, B. P., Leroux, M. R. and Swoboda, P. (2011). Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport. Developmental Biology 357, 235-247.

Hao, L., Efimenko, E., Swoboda, P. and Scholey, J. M. (2011). The retrograde IFT machinery of C. elegans cilia: Two IFT dynein complexes? PLoS ONE 6, e20995.

Li, C., Inglis, P. N., Leitch, C. C., Efimenko, E., Zaghloul, N. A., Mok, C. A., Davis, E. D., Bialas, N. J., Healey, P., Heon, E., Zhen, M., Swoboda, P., Katsanis, N. and Leroux, M. R. (2008). An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. PLoS Genetics 4, e1000044.

Laurençon, A., Dubruille, R., Efimenko, E., Grenier, G., Bissett, R., Cortier, E., Rolland, V., Swoboda, P. and Durand, B. (2007). Identification of novel Regulatory Factor X (RFX) target genes by comparative genomics in Drosophila species. Genome Biology 8, R195.

Chen, N., Mah, A., Blacque, O. E., Chu, J., Phgora, K., Bakhoum, M. W., Newbury, R. H., Khattra, J., Chan, S., Go, A., Efimenko, E., Johnsen, R., Phirke, P., Swoboda, P., Marra, M., Moerman, D. G., Leroux, M. R., Baillie, D. L. and Stein, L. D. (2006). Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome Biology 7, R126.

Efimenko, E., Blacque, O. E., Ou, G., Haycraft, C. J., Yoder, B. K., Scholey, J. M., Leroux, M. R. and Swoboda, P. (2006). Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the IFT machinery in sensory cilia. Molecular Biology of the Cell 17, 4801-4811.

Research Interests

Genetics

Molecular Biology

Cancer Biology

Drug Development