George V. Mazariegos, MD, FACS, FAST

  • Jamie Lee Curtis Professor of Surgery and Critical Care Medicine
  • Chief of Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh
  • Director, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
  • Affiliated Faculty, McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine

Administrative Assistant: Kathleen J. Smith

George V. Mazariegos, MD, FACS is Chief of Pediatric Transplantation at UPMC Children's Hospital of Pittsburgh, Hillman Center for Pediatric Transplantation and at the Thomas E. Starzl Transplantation Institute. He is a professor at the University of Pittsburgh in the departments of Surgery, Anesthesiology and Critical Care Medicine and holds the Jamie Lee Curtis Chair in Pediatric Transplantation Surgery.

Mazariegos serves as Past President for the Intestinal Rehabilitation and Transplant Association (IRTA) and Secretary/Treasurer of Studies in Pediatric Liver Transplantation (SPLIT). He is Chair of the OPTN Pediatric Transplantation Committee and an active member of the American Surgical Association and the Society for University Surgeons.

Mazariegos and colleagues founded the Starzl Network for Excellence in Pediatric Transplantation, a consortium bringing innovation and tech partners together with patients, families and transplant centers to transform outcomes in children undergoing transplantation.

Professional and Scientific Society Membership

  • Society of Critical Care Medicine, 1992-Present
  • American College of Surgeons, Fellow, 1999-Present
  • Association for Academic Surgery, 1997-Present
  • American Society of Transplantation, 1998-Present
    • Member-at-Large, Executive Committee, Pediatric Community of Practice (PCOP), 2011-2013
    • Fellow, 2016-Present
  • International Liver Transplantation Society, 1998-Present
  • The Transplantation Society, 1999-Present
  • Intestinal Rehabilitation and Transplant Association, 1999-Present
    • Councilor, 2011-Present
    • Treasurer, 2013-2015
    • Chair, Scientific Committee, 2013-2017
    • President-Elect, 2015-2017
    • President, 2017-2019
    • Past President, 2019-2021
  • American Society of Transplant Surgeons, 1999-Present
    • Membership Committee, 2010-Present
  • International Pediatric Transplant Association, 2001-Present
    • Co-Chairman, Outreach Committee, Council Liaison, 2011-2019
    • Councilor, 2011-2019
    • Nominations Committee, 2011-2019
    • Chair, Scientific Advisory Committee, 2019-Present
  • Society of University Surgeons, 2003-Present
  • American Association for the Study of Liver Diseases, 2005-Present
  • Society of Pediatric Liver Transplantation
    • Chair, Education Committee, 2006-2014
    • Vice Chair, SPLIT Council, 2011-2014
    • Chair, SPLIT Council, 2014-2016
    • Past Chair, SPLIT Council, 2016-2018
    • Secretary/Treasurer, 2018-Present
  • American Society for Parenteral and Enteral Nutrition, 2010-Present
  • American Surgical Association, 2011-Present
  • International Hepato-Pancreato-Biliary Association, 2014-Present

Education & Training

  • BS, Medical Science, Northwestern University, 1982
  • MD, Northwestern University Medical School, 1986
  • Internship in General Surgery, Michigan State University/Butterworth Hospital, 1986-1987
  • Residency in General Surgery, Michigan State University/Butterworth Hospital, 1987-1990
  • Chief Resident in General Surgery, Michigan State University/Butterworth Hospital, 1990-1991
  • Fellowship in Critical Care Medicine, University of Pittsburgh Medical Center, 1991-1992
  • Thomas E. Starzl, MD, PhD Fellowship in Transplantation, University of Pittsburgh Medical Center, 1992-1993

Selected Publications

Elisofon SA, Magee JC, Ng VL, Horslen SP, Fioravanti V, Economides J, Erinjeri J, Anand R, Mazariegos GV, Society of Pediatric Liver Transplantation Research Group. Society of pediatric liver transplantation: Current registry status 2011 – 2018. Pediatr Transplant. 2020 Feb;24(1):e13065. PMID: 31680409.

Annunziato RA, Stuber ML, Supelana CJ, Dunphy C, Anand R, Erinjeri J, Alonso EM, Mazariegos GV, Venick RS, Bucuvalas J, Shemesh E. The impact of caregiver post-traumatic stress and depressive symptoms on pediatric transplant outcomes. Pediatr Transplant. 2020 Feb;24(1):e13642. PMID: 31880384. 

Kaufman SS, Avitzur Y, Beath SV, Ceulemans LJ, Gondolesi GE, Mazariegos GV, Pironi L. New Insights into the Indications of Intestinal Transplantation – Consensus in the Year 2019. Transplantation. 2019 Nov 20. [Epub ahead of print]. PMID: 31815899.

Mogul D, Perito ER, Wood N, Mazariegos GV, VanDerwerken D, Ibrahim SH, Mohammed S, Valentino PL, Gentry S, Hsu E. Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates. Transplantation. 2019 Dec 27. [Epub ahead of print]. PMID: 31895347.

Strauss KA, Carson VJ, Soltys K, Young ME, Bowser LE, Puffenberger EG, Brigatti KW, Williams, KB, Robinson DL, Hendrickson C, Beiler K, Taylor CM, Haas-Givler B, Chopko S, Hailey J, Muelly ER, Shellmer DA, Radcliff Z, Rodrigues A, Loeven K, Heaps AD, Mazariegos GV, Morton DH. Branched-chain ɑ-ketoacid dehydrogenase deficiency (maple syrup urine disease): Treatment, biomarkers, and outcomes. Mol Genet Metab. 2020 Jan 16 [Epub ahead of print]. PMID: 31980395. 

Del Brío Castillo R, Bleesing J, McCormick T, Squires JE, Mazariegos GV, Squires J, McKiernan PJ.Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation.  Pediatr Transplant. 2020 Mar 12:e13695. doi: 10.1111/petr.13695. [Epub ahead of print] PMID: 32166868.

Dhawan A, Lawlor MW, Mazariegos GV, McKiernan P, Squires JE, Strauss KA, Gupta D, James E, Prasad S. Disease burden of Crigler-Najjar syndrome: Systematic review and future perspectives. J Gastroenterol Hepatol. 2020 Apr;35(4):530-543. doi: 10.1111/jgh.14853. Epub 2019 Oct 24. PMID: 31495946.

Stanley K, Ranganathan S, Mazariegos G, Bond G, Soltys K, Ganoza A, Sun Q, Sindhi R. Induction regimens and post-transplantation lymphoproliferative disorder after pediatric intestinal transplantation: Single-center experience.  Pediatr Transplant. 2020 May 19.

Mazariegos GV, Shneider Benjamin L, Shemesh Eyal, Schady Deborah, Melin-Aldana Hector, Cho Soo-Jin, Anand Ravinder, Erinjeri Jinson, Annunziato Rachel, Reyes-Mugica Miguel.  Approaches to research determination of late acute cellular rejection in pediatric liver transplant recipients. August 2020.  Liver Transplantation. In press. 

Feng S, Bucuvalas JC, Mazariegos GV, et al. Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Towards Personalized Management [published online ahead of print, 2020 Aug 12]. Hepatology. 2020;10.1002/hep.31520. doi:10.1002/hep.31520

Mogul DB, Perito ER, Wood N, Mazariegos GV, VanDerwerken D, Ibrahim S, Mohammed S, Valentino PL, Gentry SS, Hsu E. Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates.  Transplantation. 2020 Aug;104(8):1627-1632. doi: 10.1097/TP.0000000000003079.

Full Publication List via NIH PubMed »

Research Interest Summary

Pediatric Transplantation

Academic and Research Interests

  • Pediatric transplant network for quality improvement, patient advocacy and innovation
  • Pediatric Intestinal Failure Consortium
    • Participating in multi-center consortium for the evaluation and investigation of children with intestinal failure
  • Clinical conduct of In Vitro correlates in patients off immunosuppression 
  • Clinical conduct of SPLIT Database registry in Pediatric Liver Transplantation
  • Pediatric Unresectable Liver Tumor Observatory (PLUTO)
  • International Solid Organ Transplant Tolerance (ISSORT) Multicenter Registry
  • Weaning of Immunosuppression in Long Term Recipients of Liver Transplantation
  • Risk Factors in Pediatric Small Bowel Transplantation
  • Mechanisms and Treatment of Parenteral Nutrition Related Cholestasis in Children with Short Gut Syndrome 
  • Pediatric liver transplantation
    • Causes of late graft loss and mortality

Research Grants

Federal Communications Commission, UPMC Children's Hospital of Pittsburgh COVID-19 Telehealth Program (Co-PI), 2020, $192,500.

NIH 5U01AI104342-05, Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children (CTOTC-06) (Site PI, 5% effort), 2013-2020, $23,475.

NIH 5UM1AI109565-04, A Prospective Cohort Study of Operationally Tolerant Allograft Recipients (ALLTOL) (Site, PI, 2% effort), 2017-2021, $51,396.

NIH 5U34DK112661-02, Improving Medication Adherence in Adolescent After Liver Transplant (iMALT) (Site PI, 3% effort), 2018-2023, $201,488.