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Glenn J. Rapsinski, MD, PhD
- Instructor of Pediatrics
- Pediatric Scientist Development Program
Dr. Rapsinski is a native of the Pittsburgh area who grew up in New Kensington, PA and attended Saint Vincent College for his undergraduate education. He then attended the Lewis Katz School of Medicine at Temple University where he completed the MD/PhD program and was inducted into Alpha Omega Alpha Honors Society. His PhD research examined the development of and immune responses to extracellular components of biofilms formed by Salmonella typhimurium. He completed residency at UPMC Children's Hospital of Pittsburgh prior to starting Infectious Disease fellowship His primary research interest is bacterial respiratory tract infections including the studying the microbiome present in the sinuses and lungs of patients with cystic fibrosis and adaptations providing Pseudomonas aeruginosa competitive advantage against other bacteria in the microbiome. He is completing his fellowship research in the lab of Dr. Jennifer Bomberger. Additionally, he is interested in bacterial biofilm formation on biotic surfaces. His career goal is to be a physician scientist with an R01 funded research program and lab after completing fellowship. He is a member of the Children's Hospital of Pittsburgh Pediatric Scientist and is grant funded member of the Association of Pediatric Department Chair's Pediatric Scientist Development program.
Professional and Scientific Society Memberships
- Pediatric Infectious Diseases Society, 2017-Present
- American Academy of Pediatrics, 2016-Present
- American Medical Association, 2016-Present
- Alpha Omega Alpha, 2016-Present
- American Society for Microbiology, 2013
- Eastern Pennsylvania Branch of the American Society for Microbiology, 2011-2014
Education & Training
- BS, Saint Vincent College, 2009
- PhD, Temple University School of Medicine, 2016
- Residency in Pediatrics, UPMC Children's Hospital of Pittsburgh, 2019
Selected Publications
Wilson, RP, Tursi SA, Rapsinski, GJ, Medeiros NJ, Le LS, Kotredes KP, Patel S, Liverani E, Sun S, Zhu W, Kilpatrick L, Winter SE, Gamero AM, Tükel Ç.,STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium. PLoS Pathog, 2019. 15(4): p. e1007745.
Sick-Samuels AC, Goodman KE, Rapsinski GJ, Colantouni E, Milstone AM, Nowalk AJ, Tamma PD. “A Decision Tree Using Patient Characteristics to Predict Resistance to Commonly Used Broad-spectrum Antibiotics in Children with Gram-negative Bloodstream Infections.” J Pediatric Inf Dis Soc. (2019). Jan 25; Epublished ahead of print.
Rapsinski GJ, Makadia J, Bhanot N, Min Z. “Pseudomonas mendocina native valve infective endocarditis: a case report.” J Med Case Rep. (2016). Oct 4;10(1):275.
Oppong GO, Rapsinski GJ, Tursi SA, Biesecker SG, Klein-Szanto AJ, Goulian M, McCauley C, Healy C, Wilson RP, Tükel Ç. “Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice.” NPJ Biofilms Microbiomes. (Epub 2015). 1. Pii:15019. Oct 14.
Gallo PM1, Rapsinski, GJ1, Wilson RP, Oppong GO, Sriram U, Goulian M, Buttaro B, Caricchio R, Gallucci S, Tükel Ç. "Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity." Immunity. (2015). 42(6): 1171-84. (1Co-first authors)
Rapsinski, GJ, Wynosky-Dolfi MA, Oppong GO, Tursi SA, Wilson RP, Brodsky IE, Tükel Ç. “Toll-like receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, curli.” Infection and Immunity. (2015). 83(2):693-701.
Rapsinski, GJ, Newman TN, Oppong, GO, van Putten JP, Tükel Ç. "CD14 protein acts as an adaptor molecule for the immune recognition of Salmonella curli fibers." Journal of Biological Chemistry. (2013). 288(20): 1478-88.
Oppong GO, Rapsinski GJ, Newman TN, Nishimori JH, Biesecker SG, Tükel Ç. "Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut." Infection and Immunity. (2013). 81(2):478-86.
Nishimori JH, Newman TN, Oppong GO, Rapsinski GJ, Yen JH, Biesecker SG, Wilson RP, Butler BP, Winter MG, Tsolis RM, Ganea D, Tükel Ç. "Microbial amyloids induce interleukin 17A (IL-17A) and IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa." Infection and Immunity. (2012). 80(12):4398-408.