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Hülya Bayır, MD
- Professor of Critical Care Medicine, Environmental and Occupational Health and Pediatrics and Director, Children’s Neuroscience Institute
- Endowed Chair in Critical Care Pediatric Research
- Academic Chief of Pediatric Critical Care Medicine
- Associate Director, Center for Free Radical and Antioxidant Health, University of Pittsburgh Graduate School of Public Health
- Associate Director, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine
Professional and Scientific Society Memberships
- Society For Neuroscience, 2005-Present
- Radiation Research Society, 2006-2007
- Neurotrauma Society, 2011-Present
- The American Society for Clinical Investigation(elected member), 2014-Present
- The Association of American Physicians(elected member), 2020-Present
Education & Training
- MD, Hacettepe University, 1995
- Internship in Pediatrics, Hacettepe Children’s Hospital, 1995-1996
- Residency in Pediatrics, State University of New York, 1996-1999
- Fellowship in Pediatric Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, 1999-2002
Selected Publications
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI*, Bayır H*, Kagan VE*. Nat Chem Biol. 2020 Mar;16(3):278-290. *corresponding authors.
Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayır H, Aron AT, Chang CJ, Kagan VE, Philpott CC. Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis. Hepatology. 2020 May 21. doi: 10.1002/hep.31328. [Epub ahead of print].
Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayır H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS. Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis. Radiat Res. 2020 May;193(5):435-450.
Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayır H. Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass. Pediatr Crit Care Med. 2020 Jan;21(1):33-41.
Anthonymuthu TS, Kenny EM, Hier ZE, Clark RSB, Kochanek PM, Kagan VE, Bayır H. Detection of brain specific cardiolipins in plasma after experimental pediatric head injury. Exp Neurol. 2019 Jun;316:63-73.
Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I. Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members. J Chem Inf Model. 2019 May 28;59(5):2496-2508.
Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayır H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS.
Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow. In Vivo. 2019 May-Jun;33(3):675-688.
Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayır H. Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Crit Care Med. 2019 Apr;47(4):e292-e300.
Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H*, Ji J*. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. J Neurosci. 2019 Mar 6;39(10):1930-1943. *corresponding authors.
Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H*, Kagan VE*, Winograd N*. Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. *corresponding authors
Research Grants
1R01NS117000, Druggable mitochondrial targets for treatment of cerebral ischemia, 2020-2025
2R01NS076511, Lipid imaging in Traumatic Brain Injury by high resolution GCIB-secondary ion mass spectrometry, 2018-2023
F30HL142130, Targeting mitochondrial PARP1 in neuronal ischemia-reperfusion injury, 2018-2023
1R01NS096714, Development of serum, imaging, and clinical biomarker driven models to direct clinical management after pediatric cardiac arrest, 2016-2021
2U19AI068021, University of Pittsburgh CMCR, Signature-Directed, Sequential Delivery of Radiation Mitigators, 2015-2020
2R01NS061817, Oxidative Lipidomics in Pediatric Traumatic Brain Injury, 2014-2020
T35DK065521, Ferroptosis and acute kidney injury after pediatric cardiopulmonary bypass surgery