James E. Squires, MD, MS

  • Assistant Professor of Pediatrics
  • Fellowship Director, Pediatric Transplant Hepatology

Dr. Squires earned his medical degree from the University of Texas and went on to complete his training in general pediatrics at the Cincinnati Children’s Hospital Medical Center (CCHMC). Following residency, he completed fellowships in both pediatric gastroenterology and pediatric advanced/transplant hepatology at CCHMC. He completed a Masters in clinical and translational research focusing his thesis on the diagnostic and predictive value of serum biomarkers in children with hepatobiliary disease. Following completion of his training, Dr. Squires joined the faculty at the Children’s Hospital of Pittsburgh in 2015 where he is an assistant professor in pediatrics and the director of the pediatric advanced/transplant hepatology fellowship. Dr. Squires remains active in both clinical and research pursuits. He is a co-investigator in the Children Liver Disease Research Network (ChiLDReN), an NIH funded consortium working to improve the lives of children with rare cholestatic liver diseases. He is also a member of the Society of Pediatric LIver Transplant (SPLIT), a multifaceted organization focused on improving outcomes for children receiving liver transplantation. Current interests include metabolic liver disease, acute liver failure, and liver transplant.

Professional and Scientific Society Memberships

  • American Academy of Pediatrics Resident Membership, 2008-2011
  • American Society of Transplantation, 2011-2015
  • North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Member, 2011-Present
  • American Association for the Study of Liver Diseases (AASLD) Member, 2011-Present
  • Childhood Liver Disease Research Network (ChiLDReN) Member, 2015-Present
  • Society of Pediatric Liver Transplant (SPLIT), 2015-Present
  • Pittsburgh Liver Research Center (PLRC), 2016-Present

Education & Training

  • BA, Biology, Saint Louis University, 2004
  • MD, University of Texas Medical Branch, 2008
  • Pediatrics Internship, Cincinnati Children's Hospital Medical Center, 2008-2009
  • Pediatrics Residency, Cincinnati Children's Hospital Medical Center, 2009-2011
  • GI/Hep/Nut Fellowship, Cincinnati Children's Hospital Medical Center, 2011-2014
  • Master of Clinical and Translational Research, University of Cincinnati, 2014
  • Advanced Fellowship Transplant Hepatology, Cincinnati Children's Hospital Medical Center, 2014-2015
  • Health Sciences Leadership Academy for Early Career Faculty, University of Pittsburgh, 2018

Selected Publications

Chapin CA, Horslen SP, Squires JE, Lin H, Blondet N, Mohammad S, Alonso EM. Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis. J Pediatr. 2019 May; 208:23-29

Henkel SAF, Squires JH, Ayers M, Ganoza A, McKiernan P, Squires JE. Expanding etiology of progressive familial intrahepatic cholestasis. World J Hepatol. 2019 May 27;11(5):450-463.

McKiernan PJ, Ganoza A, Squires JE, Squires RH, Vockley J, Mazariegos G, Soltys K, Sun Q, Sindhi R. Evolving trends in liver transplant for metabolic liver disease in the United States. Liver Transpl 2019 Jun;25(6): 911 – 921. 

Celik N, Squires JE, Soltys K, Vockley J, Shellmer DA, Chang W, Strauss K, McKiernan P, Ganoza A, Sindhi R, Bond G, Mazariegos G, Khanna A. Domino live transplantation for select metabolic disorders: Expanding the living donor pool. JIMD Rep. 2019 Jul;48(1):83-89. 

Celik N, Kelly B, Soltys K, Squires JE, Vockley J, Shellmer DA, Strauss K, McKiernan P, Ganoza A, Sindhi R, Bond G, Mazariegos G, Khanna A. Technique and outcome of Domino Liver Transplantation from patients with Maple Syrup Disease: Expanding the donor pool for Liver Donor Liver Transplantation. Clin Transplant. 2019 Nov;33(11):e13721. 

Squires JE, Ng VL, Hawthorne K, Henn L, Sorensen LG, Fredricks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Neurodevelopmental Outcomes in Pre-School and School Aged Children with Biliary Atresia and their Native Liver. J Pediatr Gastroenterol Nutr. 2020 Jan;70:79-86. 

Strauss KA, Ahlfors CE, Soltys K, Mazariegos GV, Young M, Bowser LE, Fox MD, Squires JE, McKiernan P, Brigatti KW, Puffenberger EG, Carson VJ, Vreman HJ. Crigler-Najjar syndrome type 1: pathophysiology, natural history, and therapeutic frontier. Hepatology. 2019 Sep 25 [Epub ahead of print]. 

Fuhrman DY, Kellum JA, Joyce EL, Miyashita Y, Mazariegos GV, Ganoza A, Squires JE. The use of urinary biomarkers to predict acute kidney injury in children after liver transplant. Pediatr Transplant. 2020 Feb;24(1):e13608. 

Kamath BM, Ye W, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Mrray KF, Rosenthal P, Squires JE, Teckman J, Wang KS, Thompson R, Magee JC, Sokol RJ for the Childhood Liver Disease Research Network (ChiLDReN). Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. Hepatol Commun. 2020 Mar;3(4):387-398. 

Dhawan A, Lawlor MW, Mazariegos GV, McKiernan P, Squires JE, Strauss KA, Gupta D, James E, Prasad S. Disease burden of Crigler-Najjar syndrome: systemic review and future perspectives. J Gastroenerl Hepatol. 2020 Apr;35(4):530-543. 

 

Research Grants

U01DK062466 (Squires, R), 09/15/2002 - 5/31/2019, 0.60 Cal. Months, National Institutes of Health, $195,507 

The Pittsburgh Cholestatic Liver Disease Consortium. Diseases in infants that impair the liver’s ability to secrete bile (e.g. biliary atresia) are the leading indication for liver transplantation in childhood.  Multi-centered prospective investigations are essential to improve the health of children afflicted by these disorders.  The Pittsburgh Cholestatic Liver Disease Consortium at Children’s Hospital of Pittsburgh is ideally suited to participate in these prospective investigations and proposes investigations to analyze response to surgery in biliary atresia and to develop a novel therapy for a genetic form of liver disease. Squires, J is listed as Co-I. Direct contributions will include clinical protocol development and safety, data acquisition, patient recruitment, and patient management. Additional collaborative research efforts will be supported by this grant. 

 

R01 DK117916 (PI: Fox, I and Vockley, G) 07/01/17-06/30/22,1.00 Cal. Months, National Institutes of Health, $685,236 

Hepatocyte Transplantation for Liver-Based Metabolic Disease. In this study, we will treat patients with liver-based metabolic disease by hepatocyte transplantation with the goal of opening the door for broader use of hepatocyte transplants in the treatment of metabolic liver disease. Squires, J is listed as Co-I. Direct contributions will include the clinical protocol development and safety, data acquisition, and patient management – particularly in the post-transplant period. 

 

American Legion Child Welfare Foundation Award (PI: Mazariegos), 1/1/2020-12/31/20, The American Legion, $30,000 

Teach for the Starz(l); Online Resources for Child Liver Transplant Patients and their Families. This project will create an online portal of resources for children and their families who have received a liver transplant. Squires, J is listed as Co-I. Direct contributions will include the clinical and educational materials development and dissemination plan. 

 

AASLDF 50043 (PI: Squires, J) 07/01/19-06/30/20, 2.40 Cal. Months, American Association for the Study of Liver Diseases Foundation, $20,000  

A Learning Health System for Pediatric Autoimmune Liver Disease. The proposed research is a direct outgrowth of previous co-investigators in this application, as well as others, that have demonstrated the ability to use existing network organizational architecture to support the development of LHS. Based in part on these experiences, we now propose to expand LHS advancements, in particular those established through the ICN network, into the new arena of AILDs where disease parallels and shared populations exist. The Pilot Research Award will be used to advance the ‘Design and Development’ and ‘Outcome Identification’ phases of a new LHS focused on Autoimmune Liver Diseases, built within and through support of an ICN collaboration.