Jeffrey Alan Rudolph, MD

  • Vice Chair of Clinical Affairs and Associate Professor of Pediatrics
  • Medical Director, Intestinal Care and Rehabilitation, UPMC Children's Hospital of Pittsburgh

Administrative Assistant: Stephanie Tavormina

Dr. Jeffrey Rudolph is an Associate Professor in the Division of Gastroenterology, Hepatology, and Nutrition. He completed his undergraduate work at Yale University and medical school training at the University of Pittsburgh Medical School. Dr. Rudolph went on to complete his pediatric residency at St. Louis Children’s Hospital and pediatric gastroenterology fellowship at Cincinnati Children’s Hospital Medical Center.

Dr. Rudolph joined the Division of Gastroenterology in 2009 to serve as the Medical Director of the Intestinal Care and Rehabilitation Program at UPMC Children’s Hospital of Pittsburgh. His clinical interests are in the care of children with intestinal failure as well as those that go on to intestinal transplant. He has served as the Clinical Director of Pediatric Gastroenterology from 2018-2020 and currently holds the position of Vice Chair of Clinical Affairs in the Department of Pediatrics.

Professional and Scientific Society Membership

  • North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), 2002-Present
  • American Society for Parenteral and Enteral Education, 2014-Present

Education & Training

  • BS, Biology, Yale University, 1989
  • MD, University of Pittsburgh School of Medicine, 1994
  • Internship in Pediatrics, St. Louis Children's Hospital, 1994-1995
  • Residency in Pediatrics, St. Louis Children's Hospital, 1995-1997
  • Fellowship in Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, 1997-2000
  • Postdoctoral Research Fellowship in Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, 1997-2000

Selected Publications

Garin-Laflam MP, Steinbrecher KA, Rudolph JA, Mao J, Cohen MB. Activation of guanylate cyclase signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4): G740-9. PubMed PMID: 19221018.

Pasternak BA, Collins MH, Tiao GM, Rudolph JA, Alonso MH, Ryckman FC, Kocoshis SA. Anatomic and histologic variability of epithelial apoptosis in small bowel transplants. Pediatr Transplant. 2010 Feb;14(1): 72-6. PubMed PMID: 19207229.

Ningappa M, Higgs BW, Weeks DE, Ashokkumar C, Duerr RH, Sun Q, Soltys KA, Bond GJ, Abu-Elmagd K, Mazariegos GV, Alissa F, Rivera M, Rudolph J, Squires R, Hakonarson H, Sindhi R. NOD2 Gene Polymorphism rs2066844 Associates With Need for Combined Liver-Intestine Transplantation in Children With Short-Gut Syndrome.Am J Gastroenterol. 2011 Jan;106(1): 157-65. PubMed PMID: 20959815.

Kevan EN, Simmons JR, Kocoshis SA, Cohen MB, Rudolph JA. sTREM-1 and LBP in central venous catheter-associated bloodstream infections in pediatric intestinal failure. J Pediatr Gastroenterol Nutr. 2011 Dec;53(6): 627-33. PubMed PMID: 21701408.

Squires RH, Duggan C, Teitelbaum DH, Wales PW, Balint J, Venick R, Rhee S, Sudan D, Mercer D, Martinez JA, Carter BA, Soden J, Horslen S, Rudolph JA, Kocoshis S, Superina R, Lawlor S, Haller T, Kurs-Lasky M, Bell SH. Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. J Pediatr. 2012 Oct; 161(4): 723-8.  PubMed PMID: 22578586.

Ningappa M, Ashokkumar C, Ranganathan S, Schmitt L, Higgs BW, Sun Q, Branca M, Mazariegos G, Zeevi A, Abu-elmagd K, Squires R, Rudolph J, Alissa F, Hakonarson H, Sindhi R. Mucosal plasma cell barrier disruption during intestinal transplant rejection.  Transplantation. 2012 Dec 27;94(12): 1236-42. PubMed PMID: 23269450.

Khan FA, Squires RH, Litman HJ, Balint J, Carter BA, Fisher JG, Horslen SP, Jaksic T, Kocoshis S, Martinez JA, Mercer D, Rhee S, Rudolph JA, Soden J, Sudan D, Superina RA, Teitelbaum DH, Venick R, Wales PW, Duggan C; Pediatric Intestinal Failure Consortium. Predictors of Enteral Autonomy in Pediatric Intestinal Failure: A Multicenter Cohort Study.  J Pediatrics. 2015, Jul;167: 29-34. PMID: 25917765.

Bloodstream Infections in Patients with Intestinal Failure Presenting to a Pediatric Emergency Department with Fever and a Central Line. Szydlowski EG, Rudolph JA, Vitale MA, Zuckerbraun NS. Pediatr Emerg Care. 2017 Dec;33(12): e140-e145. PMID: 27455342

Prophylactic rtPA in the Prevention of Line-associated Thrombosis and Infection in Short Bowel Syndrome. Malec LM, Cooper J, Rudolph J, Michaels MG, Ragni MV. J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):972-975. PMID:29135819

Pediatric Intestinal Transplantation. Celik N, Mazariegos GV, Soltys K, Rudolph JA, Shi Y, Bond GJ, Sindhi R, Ganoza A. Gastroenterol Clin North Am. 2018 Jun;47(2):355-368. Review. PMID: 29735029 

Improvements in intestine transplantation. Celik N, Stanley K, Rudolph J, Al-Issa F, Kosmach B, Ashokkumar C, Sun Q, Brown-Bakewell R, Zecca D, Soltys K, Khanna A, Bond G, Ganoza A, Mazariegos G, Sindhi R. Semin Pediatr Surg. 2018 Aug;27(4):267-272. doi: 10.1053/j.sempedsurg.2018.07.001. Epub 2018 Jul 29. Review. PMID:30342602

Full Publication List via NIH PubMed »

Academic and Research Interests

  • Medical management of intestinal failure in pediatric patients
  • Mechanisms of acute cellular rejection in small bowel allografts