Jie Lu, MS
Jie Lu joined the De Vallejo lab in 2019 as a technician. She runs day-to day bench work, and contributes to projects in the lab. Currently she is exploring the role of MnP in TgTNF mice with arthritis. She is also working on using mouse bone marrow transplantation on aging study, after adoptive transfer T cells and B cells can be tested in different time using flow cytometry, so develop a model of the immune dimension of lifespan extension in mice.
Education & Training
- MS, Sanitary Technology, West China University of Medical Sciences, 1996
Junjie Zhu, Pengchen Wang, Amina Shehu, Jie Lu, Huichang Bi, Xiaochao Ma Identification of Novel Pathways in Idelalisib Metabolism and Bioactivation 2018;31(7):548-555
Junjie Zhu, Pengcheng Wang, Feng Li, Jie Lu, Amina Shehu, Wen Xie, Deborah Mcmahon, Xiaochao Ma. CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor.2018,158:174-184.
Pengcheng Wang,Shehu Al,Jie Lu, Rujuta H.Joshi, RamanVenkataramanan, Kim S Sugamori, Denis M.Grant, Xiao-boZhong, Xiaochao Ma Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. 2017;145:218-225
Pengcheng Wang,Shehu Al,Ke Liu,Jie Lu, Xiaochao Ma, Biotransformation of cobicistat: metabolic pathways and enzymes.Drug Metab Lett. 2016;10(2):111-23.
Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie, and Xiaochao Ma. Bedaquiline metabolism: enzymes and novel metabolites. Drug. Metab. Dispos, 2014, 42(5):863-866.
Feng Li, Jie Lu, Xiaochao Ma. CPY3A4-mediated α-hydroxyaldehyde formation in saquinavir metabolism. Drug. Metab. Dispos, 2014, 42(2):213-220.
Ke Liu, Feng Li, Jie Lu, Zhiwei Gao, Curtis D. Klaassen, Xiaochao Ma. Role of CYP3A in isoniazid metabolism in vivo. Drug Matab. Pharmakinet, 2014, 29(2):219-222.
Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan L Csanaky, Curtis D Klaassen, Frank J Gonzalez, Xiaochao Ma. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nature Medicine, 2013,19(4):418-420 .
Feng Li, Jie Lu, Xiaochao Ma. CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir. Drug. Metab. Dispos, 2012, 40(1):18-24.
Feng Li, Jie Lu, Xiaochao Ma. Metabolomic Screening and Identification of the Bioactivation Pathways of Ritonavir. Chem. Res. Toxicol, 2011, 24(12), 2109-2114.