Jirair Krikor Bedoyan, MD, PhD, FACMG

  • Associate Professor of Pediatrics
  • Program Director, Clinical Biochemical Genetics Fellowship, UPMC Children's Hospital of Pittsburgh

Bedoyan is an associate professor of pediatrics at the University of Pittsburgh School of Medicine in the Division of Genetic and Genomic Medicine. He is also the program director of the Clinical Biochemical Genetics Fellowship Program at UPMC Children’s Hospital of Pittsburgh.

Bedoyan received his undergraduate degree in Chemistry with a minor in Physics from Washington State University, Pullman, WA in 1987, and also earned a Master degree in Microbiology in 1989. He then received a PhD in Cellular and Molecular Biology from the University of Michigan, Ann Arbor, MI in 1996. Following graduation, Bedoyan worked as a postdoctoral fellow in the Basic Sciences Division of the Fred Hutchinson Cancer Research Center, Seattle, WA and subsequently, at the John D. Dingle Veteran Affairs Medical Center, Detroit, MI. Bedoyan received his Doctor of Medicine degree at Wayne State University School of Medicine, Detroit, MI in 2004, and in 2007 completed a residency in Pediatrics at the UPMC Children’s Hospital of Pittsburgh. He subsequently completed a residency in Medical Genetics at the University of Michigan in 2010 and a fellowship in Clinical Biochemical Genetics fellowship at Case Western Reserve University in 2014.

Bedoyan is a biochemical geneticist interested in investigating the genetics and pathophysiology of several inborn errors of metabolism including disorders of pyruvate metabolism, particularly mitochondrial pyruvate dehydrogenase complex deficiency. He has published more than 50 articles, reviews, and book chapters. He has an active clinical research program, with several government-funded and industry-sponsored clinical studies/trials. Bedoyan served as the site co-PI (2014-19) and now PI (2019-24) for the North American Mitochondrial Disease Consortium an NIH funded U54 Rare Disease Clinical Research Network consortium focusing on mitochondrial and pyruvate metabolism. He is also PI of a pilot protocol for newborn screening of pyruvate dehydrogenase complex deficiency. Bedoyan has achieved local and national recognition for excellence in patient care and for his novel scholarly work to improve patient care and health outcomes for several complex inherited disorders of energy metabolism.

Professional and Scientific Society Memberships

  • Society for the Study of Inborn Errors of Metabolism, 2020-Present
  • Mitochondrial Medicine Osciety, 2014-Present
  • Society for Inherited emtabolic Disorders, 2013-Present
  • American College of Medical Genetics and genomics, 2011-Present
  • American Medical Association, 2007-Present
  • American Society of Human Genetics, 2005-2020
  • American Society of Huam n Genteics, 2003-2013
  • American Association for Cancer Research, 1991-2000

Education & Training

  • BS, Chemistry Washington State University, 1987
  • MS, Microbiology, Washington Stae University, 1989
  • PhD, Cellular and Molecular Biology, University of Michigan, 1996
  • MD, Wayne Sate University School of Medicine, 2004
  • Residency in Pediatrics, UPMC Children's Hospital of Pittsburgh, 2004-2007
  • Residency in Medical Genetics, University fo Michigan, 2007-2010
  • Fellowship in Clinical Biochemical Genetics, University Hospitals Cleveland Medical Center and Case Western reserve University, 2012-2014

Selected Publications

Academic and Research Interests

  • IEM
  • Inborn Error of Metaboliam
  • Biochemical Genetics
  • Pyruvate Dehydrognase Complex Deficiency
  • Newborn Screening
  • Small Molecule Therapy, 
  • Gene Therapy