John F. Eisses, M.D., Ph.D.

  • Assistant Professor of Pediatrics

Advisory Committee Membership

  • Member, Pancreas Committee, NASPGHAN
  • Member, Pediatric Pancreatology Consortium, INSPPIRE

Editorships

  • Associate editor, GI Scholarly Newsletter, Children’s Hospital of Pittsburgh

Professional Affiliations/Society Memberships

NASPGHAN • European Pancreas Club

AGA • American Pancreatic Association Pediatric Pancreatology Consortium, INSPPIRE

Collaborative Alliance for Pancreatic Education and Research

Education & Training

  • MD: Oregon Health & Science University Portland, OR
  • Residency: University of Pittsburgh School of Medicine Pittsburgh, PA
  • Fellowships: University of Pittsburgh School of Medicine Pittsburgh, PA

Research Grants

John Eisses’ research focuses on understanding the role of epigenetic modifiers in regulating injury and recovery of the pancreas as it relates to pancreatic disease. He studies epigenetic regulation of pancreatitis in distinct cell types within the pancreas. Pancreatitis is a life-threatening inflammatory disorder that lacks targeted therapies. Injury and inflammation activate pancreatic stellate cells (PSCs), resulting in the remodeling of the pancreatic microenvironment, which allows pancreatic recovery to occur. Prolonged injury or aberrant regulation of PSCs has been implicated in the development or promotion of several pancreatic diseases, including chronic pancreatitis and pancreatic cancer. The overall goal of the current proposal is to examine novel epigenetic mechanisms by which pancreatic recovery is regulated in response to injury, particularly in the context of PSCs. The hypothesis is that the epigenetic regulation of gene expression in PSCs is crucial for activation and repression of gene expression necessary to promote a microenvironment suitable for pancreatic regeneration. The research is significant because it elucidates for the first time an epigenetic mechanism for regenerative signals important in regulating the pancreatic microenvironment to allow pancreatic recovery. On a much broader level, it opens a new paradigm of possible therapeutic strategies that may enhance the ability of the pancreas to recover, particularly in the context of remodeling the extracellular matrix and the pancreatic microenvironment by PSCs. 

Division