Jon D. Piganelli, PhD

  • Associate Professor of Surgery

After graduation from the Department of Microbiology at Oregon State University, Piganelli moved on to postdoctoral training at the Barbara Davis Center for Childhood Diabetes and the Department of Immunology at the University of Colorado School of Medicine. Where he focused his research and training in cellular immunology, more specifically on understanding why the immune system recognizes the cells responsible for producing insulin, islet beta cells, as foreign, leading to type 1 diabetes.  

His training further encompasses the role of free radical signaling in modulation of immune function. Piganelli has also taught both graduate and medical students for the school of medicine throughout his tenure as well as serving on over 75 thesis committees both nationally and internationally. He is also involved heavily in recruiting potential graduate students to the interdisciplinary biomedical graduate program at the university. As a minority investigator he has been very active in recruiting and attending McNair scholars and the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science recruitment meetings.

Professional and Scientific Society Memberships

  • Help A Diabetic Child Foundation Board of Directors, 2015-Present
  • American Association of Immunologist, 2002-Present
  • Society of Porphyrins & Phthalcyanines, 2008-Present
  • Immmunology of Diabetes Society, 2004-Present
  • NIDDK Network of Minority Research Investigators, 2002-Present
  • American Diabetes Association, 2002-Present
  • The Oxygen Society, 2001-Present
  • International Society of Developmental and Comparative Immunology, 1991-Present
  • American Society for Microbiology, 1991-1993

Education & Training

  • BS, Microbiology, Colorado State University, 1988
  • PhD, Microbiology, Oregon State University, 1994
  • Postdoctoral Fellowship, Immunology, Barbara Davis Center for Childhood Diabetes University of Colorado Health Sciences Center , 1999

Selected Publications

Martins CP, New LA, O'Connor EC, Previte DM, Cargill KR, Tse IL, Sims-Lucas S, Piganelli JD: Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4(+) T Cells in Type 1 Diabetes. Front Immunol 2021, 12:66945

Bassin EJ, Piganelli JD, Little SR: Auto-antigen and Immunomodulatory Agent-Based Approaches for Antigen-Specific Tolerance in NOD Mice. Curr Diab Rep 2021, 21:9.

Piganelli JD, Mamula MJ, James EA: The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes. Frontiers in endocrinology 2020, 11:624590.

Bassin EJ, Buckley AR, Piganelli JD, Little SR: TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model. PloS one 2020, 15:e0239396

Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, Previte DM, Dong HH, Michalopoulos GK, Mars WM, Piganelli JD: A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes. Am J Pathol 2019

Previte DM, Martins CP, O'Connor EC, Marre ML, Coudriet GM, Beck NW, Menk AV, Wright RH, Tse HM, Delgoffe GM, Piganelli JD: Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4(+) T Cells. Cell reports 2019, 27:129-41 e4.

Previte DM, O'Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD: Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation. PloS one 2017, 12:e0175549.

Previte DM, Piganelli JD: Reactive Oxygen Species and Their Implications on CD4(+) T Cells in Type 1 Diabetes. Antioxidants & redox signaling 2017.

Buitinga, M., A. Callebaut, F. Marques Camara Sodre, I. Crevecoeur, G. Blahnik-Fagan, M. L. Yang, M. Bugliani, D. Arribas-Layton, M. Marre, D. P. Cook, E. Waelkens, R. Mallone, J. D. Piganelli, P. Marchetti, M. J. Mamula, R. Derua, E. A. James, C. Mathieu, and L. Overbergh. 2018. Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes. Diabetes 67: 2337-2348.

Ian D. Ferguson, Patricia Griffin, Joshua J. Michel, Hiroshi Yano, Sarah L. Gaffen, Robert G. Mueller, Jeffrey A. Dvergsten, Jon D. Piganelli, Margalit E. Rosenkranz, Daniel A. Kietz, and Abbe N. Vallejo. T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in JuvenileIdiopathic Arthritis 2018 Frontiers in Immunology Published August 6.

Academic and Research Interests

  • Diabetes
  • Autoimmunity
  • Immunometabolism
  • Free Radical Signaling
  • Transplantation Tolerance
  • T cells