Krishnan Raghunathan, PhD

  • Research Assistant Professor of Pediatrics

Krishnan Raghunathan, PhD, is a membrane biophysicist by training and his interests lie in understanding how the diversity in composition affects membrane organization and function. In the laboratory of Terence Dermody, MD, he is studying these aspects of membrane biology in the context of virus-host interactions. In particular, he uses microscopy and lipidomic tools to understand physicochemical aspects of how chikungunya virus remodels the membrane. He is further interested in the functional consequence of these changes from the perspectives of both the host and the virus, and their extension to other alphaviruses.

Professional and Scientific Society Memberships

  • SPIE - The International Society for Optical Engineering, 2009-2012
  • American Society of Cell Biology, 2012-2016
  • American Heart Association, 2014-2016
  • Biophysical Society, 2009-Present
  • American Society of Virology, 2017-Present

Education & Training

  • BTech, Anna University (India), 2006
  • PhD, Biophysics, University of Michigan, 2012
  • Postdoctoral Research Fellow, University of Michigan at Ann Arbor, 2012-2014
  • Postdoctoral Research Fellow, Vanderbilt University, 2014-2017

Selected Publications

Milstein JN, Chu MC, Raghunathan K, Meiners JC (2012) Two-Color DNA Nanoprobe of Intracellular Dynamics, Nano letters 12 (5), 2515-2519 

Raghunathan K, Ahsan A, Ray D, Nyati MK, Veatch SL (2015) Insights into role of membrane physical properties in development of cisplatin resistance, PloS One 10 (10), e0140925

Tiwari A, Copeland CA, Han B, Hanson CA, Raghunathan K, Kenworthy AK. (2016) Caveolin-1 is an aggresome-inducing protein, Sci Rep. 6:38681

Han B, Copeland CA, Kawano Y, Rosenzweig EB, Austin ED, Shahmirzadi L, Tang S, Raghunathan K, Chung WK, Kenworthy AK (2016) Characterization of a caveolin-1 mutation associated with both PAH and congenital generalized lipodystrophy, Traffic. 17(12):1297-1312

Klaus CJ*, Raghunathan K*, DiBenedetto E, Kenworthy AK. (2016) Analysis of diffusion in curved surfaces and its application to tubular membranes, Mol Biol Cell. 27(24):3937-3946

Raghunathan K, Wong TH, Chinnapen DJ, Lencer WI, Jobling MG, Kenworthy AK. (2016) Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains, Biophys J. 111(12):2547-2550

Simunovic M, Manneville JB, Renard HF, Evergren E, Raghunathan K, Bhatia D, Kenworthy AK, Voth GA, Prost J, McMahon HT, Johannes L, Bassereau P, Callan-Jones A. (2017) Friction mediates scission of tubular membranes scaffolded by BAR proteins, Cell 170(1):172-184.e11

Raghunathan K*, Foegeding NJ*, Campbell AM, Cover TK, Ohi M, Kenworthy AK (2018) Determinants of raft partitioning of the Helicobacter pylori pore-forming toxin VacA, Infection and Immunity 86 (5) 00872-17

Raghunathan K#, Kenworthy AK# (2018) Dynamic pattern generation in cell membranes: current insights into membrane organization, BBA-Biomembranes 1860:2018-2031

Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K, McAllister N, Silva LA, Morrison TE, Dermody TS. Chikungunya virus replication in skeletal muscle cells is required for disease development. Journal of Clinical Investigation 130 (3), 1466-1478

Aravamudhan P, Raghunathan K, Konopka-Anstadt J, Pathak A, Carter BD, Dermody TS Macropinocytosis drives reovirus neuronal entry and subsequent fast axoznal transport to establish infection. PLoS Pathogens16 (2), e1008380