Liheng Yang, PhD

  • Postdoctoral Fellow

Liheng Yang grew up in a northern county in China. He recieved his PhD degree in Biochemistry and Molecular Biology from Wuhan Institute of Virology, Chinese Academy of Sciences in China in 2016, then moved on to perform postdoctoral studies in Molecular and Cellular Cancer Biology Program, UPMC Hillman Cancer Center. Now he is working as an interantioal postdoctoral fellow in Dr. Coyne's lab. His current research interests are primarily focused on the mechanisms used by Enetrovuruses to breach the gastrointestinal (GI) epithelium by utilizing human and mouse GI epithelium-derived enteroids ex vivo model. He is also highly interested in developing various organs' adult stem cell derived organoids model, which can be employed as disease model including the virus infection model. 

Education & Training

  • BS, Henan University of Science and Technology, 2008
  • MS, Gansu Agricultural University, 2011
  • PhD, Wuhan Institute of Virology, 2016

Selected Publications

Leibowitz, B.J., Yang, L., Wei, L., Buchanan, M.E., Rachid, M., Parise, R.A., Beumer, J.H., Eiseman, J.L., Schoen, R.E., Zhang, L. and Yu, J. (2018) Targeting p53-dependent stem cell loss for intestinal chemoprotection. Science Translational Medicine 10(427): eaam7610. 

Dongshi Chen, Jingshan Tong, Liheng Yang, Liang Wei, Donna B Stolz, Jian Yu, Jianke Zhang, Lin Zhang (2018) PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proceedings of the National Academy of Sciences. 115:3930-3935. 

Liheng Yang, Zhenxing Gao, Lipeng Hu, Guiru Wu, Xiaowen Yang, Lihua Zhang, Ying Zhu, Boon-Seng Wong, Wei Xin, Man-Sun Sy, Chaoyang Li.(2016) Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Cells and Increases Cancer Cell Motility. J. Biol. Chem. 291: 3905-3917. 

Yang, L., Zhang, Y., Hu, L., Zhu, Y., Sy, M. S., and Li, C. (2014) A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells. Virologica Sinica 29, 228-236. 

Research Interests

The mechanisms used by Enetroviruses to breach the GI epithelium by utilizing human and mouse GI epithelium-derived enteroids ex vivo model.