Melissa Eileen Kane, PhD
- Assistant Professor of Pediatrics
Administrative Assistant: Colleen Kelly
Dr. Melissa Kane attended Cornell University for her undergraduate education where she received a B.S. in Animal Science. She conducted her doctoral research at the University of Chicago in the laboratory of Dr. Tatyana Golovkina on genetic and immunological mechanisms of resistance to retroviral infections in murine models. Her postdoctoral work in the laboratory of Dr. Paul Bieniasz at the Aaron Diamond AIDS Research Center/Rockefeller University focused on intrinsic cellular defenses against retroviral infection and interactions between HIV-1 and cellular nucleocytoplasmic trafficking pathways.
Dr. Kane joined the faculty in the Center for Microbial Pathogenesis and Division of Infectious Diseases in January 2019. The central focus of the Kane Lab is understanding the genetic and immunological basis for protective antiviral immune responses, as well as the molecular details underlying the direct inhibition of retroviral replication by restriction factors. The laboratory utilizes both in vitro and in vivo tools to investigate intrinsic, innate, and adaptive immune responses to retroviral infection. In addition, the laboratory is exploring intrinsic immunity against emerging viral infections that disproportionately affect the pediatric population.
Education & Training
- BS, Cornell University, 2004
- PhD, University of Chicago, 2011
- Postdoctoral Fellow, Rockefeller University/ Aaron Diamond AIDS Research Center, 2018
Kane, M., Rebensburg, S., Takata, M., Zang, T.M., Yamashita, M., Kvaratskhelia, M., Bieniasz, P.D. 2018. Nuclear pore heterogeneity affects HIV-1 infection and the antiviral activity of Mx2. PMID: 30084827.
Kane, M*., Deiss, F., Chervonsky, A.V., Golovkina, T. 2018. A single locus controls interferon gamma-independent antiretroviral neutralizing antibody responses. J Virol. PMID: 29875252 *- Corresponding author
Denzin, L.K., Khan, A.A., Virdis, F., Wilks, J., Kane, M., Beilinson, H., Dikiy, S., Case, L.K., Roopenian, D., Witkowski, M., Chervonsky, A.V., Golovkina, T. 2017. Neutralizing antibody responses to viral infections are linked to the non-classical MHC class II gene Ob. Immunity 47(2):310-322.e7. PMID: 28813660.
Kane, M*., Zang, T.M*., Rihn, S.J*., Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C.M., Wilson, S.J., Bieniasz, P.D. 2016. Identification Interferon-Stimulated Genes with Antiretroviral Activity. Cell Host Microbe 20(3):392-405. PMID: 27631702. *-These authors contributed equally
Busnadiego, I., Kane, M., Rihn, S., Preugschas, H., Hughes, J., Blanco-Melo, D., Strouvelle, V., Zang, T., Willett, B., Boutell, C., Bieniasz, P.D., and Wilson, S.J. 2014 Host and viral determinants of Mx2 antiretroviral activity. J Virol 88(14)7738-52. PMID:24760893
Kane, M., Yadav, S.S., Bitzegeio, J., Kutluay, S.B., Zang, T., Wilson, S.J., Schoggins, J.W., Rice, C.M., Yamashita, M., Hatziooannou, T., Bieniasz, P.D. 2013. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502:563-6. PMID: 24121441
Beyer, A.R., Bann, D.V., Rice, B., Pultz, I.S., Kane, M., Goff, S.P., Golovkina, T.V., Parent, L.J. 2012. Nucleolar trafficking of the mouse mammary tumor virus gag protein induced by interaction with ribosomal protein L9. J Virol 87:1069-82, PMID: 23135726.
Kane, M., Case, L.K., Kopaskie, K., Kozlova, A., MacDearmid, C., Chervonsky, A.V., Golovkina, T.V. 2011. Successful virus transmission depends on microbiota. Science 334:245-9. PMID: 21998394.
Kane, M., Case, L.K., Wang, C., Yurkovetskiy, L., Dikiy, S., Golovkina T.V. 2011. Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry. Immunity 35:135-145. PMID: 21723157.
Kane, M., Case, L.K., Golovkina T.V. 2011. Vital role for CD8+ cells in controlling retroviral infections. J Virol 85:3415-3423. PMID: 21248041.