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Mioara D. Manole, MD, FAAP

  • Associate Professor of Pediatrics and Pharmacy and Therapeutics
  • Associate Director, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine

Administrative Assistant: Deborah Irwin

After completing a fellowship in Pediatric Emergency Medicine, Manole pursued organized research training in Neurointensive Care at the Safar Center for Resuscitation Research, supported by an NSRA Scholars Award. She established research independence as the principal investigator of university, NIH, and American Heart Association-funded grants. As a clinician-scientist in the Division of Emergency Medicine, Manole’s ultimate goal is translation of novel therapeutic approaches developed in the laboratory to the clinical care of children who suffer cardiac arrest. Her long-term research goal is to elucidate vascular pathways involved in cerebral vascular dysregulation and to develop therapeutic strategies that improve outcome after asphyxial CA.  

Manole is a prominent educator for the pediatric emergency medicine fellows at UPMC Children’s Hospital of Pittsburgh. She is the Director of Basic Research and Chair of the Fellowship Research Scholarship Oversight Committee for Pediatric Emergency Medicine. Manole has served as mentor for undergraduate, postdoctoral and medical students, as well as residents and critical care fellows.

Manole is Associate Director of the University of Pittsburgh's Safar Center for Resuscitation Research. Nationally, Manole has an active role in the mission of the American Heart Association.

Membership in Professional and Scientific Societies

  • American Academy of Pediatrics, 1999-Present
  • Society for Neuroscience, 2008-Present
  • Society for Cerebral Blood Flow and Metabolism, 2008-PResent
  • Society for Pediatric Research, 2013-Present 

Education & Training

  • MD, Iuliu Hatieganu University of Medicine (Cluj, Romania), 1997
  • Internship in Pediatrics, Lincoln Medical and Mental Health Center, 1999-2000
  • Residency in Pediatrics, UPMC Mercy Children's Medical Center, 2000-2002
  • Fellowship in Pediatric Emergency Medicine, UPMC Children's Hospital of Pittsburgh, 2003-2006
  • Research Fellowship in Neurointensive Care, University of Pittsburgh, 2006-2008
  • Course in Scientific Leadership, University of Pittsburgh Office of Academic Career Development, 2010
  • Advanced Faculty Leadership Academy, University of Pittsburgh Office of Academic Career Development, 2017

Selected Publications

A Case of Lenticulostriate Stroke Due to Minor Closed Head Injury in a 2-Year-Old child: Role of Mineralizing Angiopathy. Fidan E, Cummings DD, Manole MD. Pediatr Emerg Care. 2017 Jul 3. doi: 10.1097/PEC.0000000000001229. [Epub ahead of print] PMID: 28816772

Difficult Intubation and Ventilation in an Infant With Retropharyngeal Abscess With Mediastinal Extension. Bruno MA, Drabek T, Manole MD. Pedatr Emerg Care. 2017 Jul 17. doi: 10.1097/PEC.0000000000001242. [Epub ahead of print] PMID: 28719483

Cardiac Arrest Secondary to Lighting Strike: Case Report and Review of the Literature. Rotariu EL, Manole MD. Pediatr Emerg Care. 2017 Aug 1. doi: 10.1097/PEC.0000000000001255. [Epub ahead of print] PMID: 28767532

Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest. Li L, Poloyac SM, Watkins SC, St Croix CM, Alexander H, Bibson GA, Loughran PA, Kirisci L, Clark RS, Kochanek PM, Vazquez AL, Manole MD. J Cereb Blood Flow Metab. 2017 Dec 1:271678X17744717. doi: 10.1177/0271678X17744717 [Epub ahead of print] PMID: 29192562

Adenosine Administration With a Stopcock Technique Delivers Lower-Than-Intended Drug Doses. Weberding NT, Saladino RA, Minnigh MB, Oberly PJ, Tudorascu DL, Poloyac SM, Manole MD. Ann Emerg Med. 2018 Feb;71(2):220-224. doi: 10.1016/j.annemergmed.2017.09.002. Epub 2017 Oct 28. PMID: 29089171

Management and Outcome of Pediatric Patients With Transient Small Bowel-Small Bowel Intussusception. Melvin JE, Zuckerbraun NS, Nworgu CR, Mollen KP, Furtado AD, Manole MD. Pediatr Emerg Care. 2018 May 5. doi: 10.1097/PEC.0000000000001503. [Epub ahead of print] PMID: 29746364 

Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin. Wolf MS, Chen Y, Simon DW, Alexander H, Ross M, Gibson GA, Manole MD, Bayir H, Kochanek PM, Clark RSB. J Neurosci Methods. 2018 Oct 5. pii: S0165-0270(18)30298-X. doi: 10.1016/j.jneumeth. 2018.09.031. [Epub ahead of print] PMID: 30292824

Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR, Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD. The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5. [Epub ahead of print] PMID: 30367162 

Cramer N, Manole M. Unresponsive 4-Year-Old Boy Found to Have X-Linked Adrenoleukodystrophy. Neuropediatrics. 2019 Oct 29. doi: 10.1055/s-0039-1697622.

Noorbakhsh KA, Williams AE, Langham JJW, Wu L, Krafty RT, Furtado AD, Zuckerbraun NS, Manole MD. Management and Outcomes of Spontaneous Pneumomediastinum in Children. Pediatr Emerg Care. 2019 Aug 23. 4.

Ramgopal S, Ramprasad VH, Manole MD, Maguire RC. Expansile Superabsorbent Polymer Ball Foreign Body in the Ear. J Emerg Med. 2019 Jun;56(6):e115-e117.

Full Publication List via NIH PubMed »