Mousumi Moulik, MD
- Assistant Professor of Pediatrics
- Director, Pediatric Cardiovascular Genetics Clinic, UPMC Children's Hospital of Pittsburgh
Moulik is a board-certified pedaitric cardiology and NIH funded physician-scientist. Her clinical and research expertise is in the field of cardiovascular genetics, heart failure and cardiomyopathies.
She obtained her medical degree from the All India Institute of Medical Sciences (AIIMS)New Delhi. She completed her Pediatric Residency training from Baylor College of Medicine, Houston and Pediatric Cardiology Fellowship from Baylor College of Medicine, Houston. She has been recognized with multiple awards during her training including Women in Cardiology Trainee Award for Excellence from the American Heart Association, Young Investigator Award from the American Academy of Pediatrics and Fellow Basic Research Award from the Society for Pediatric Research.
Moulik's clinical expertise is in cardiovascular genetics, cardiomyopathies, connective tissue disorders resulting in aortopathies, general cardiology and noninvasive cardiac imaging. She is the Director of the Cardiovascular Genetics Clinic at UPMC Children's Hospital of Pittsburgh. The focus of this clinic is to determine an underlying genetic etiology for inherited familial cardiovascular disorders including various forms of cardiomyopathies, heart rhythm disorders, aortic aneurysms, inherited lipid disorders, unexplained sudden cardiac arrest and help families with appropriate risk assessment and clinical screening of at-risk family members. Moulik also leads an NIH funded research lab with focus on heart failure signaling.
Her academic mission is to forward the understanding and treatment of heart failure by defining the underlying molecular genetics and fundamental molecular mechanisms of heart failure. Current ongoing research projects in her laboratory include determination of the role of 'Hippo' pathway in heart failure, understanding the circadian biology of cardiac function and heart failure, metabolic abnormalities of heart failure, immunologic mechanisms of myocarditis and causes of infantile cardiomyopathies. As an educator, Moulik is actively involved in training of medical students, residents and fellows, both as a clinician and a researcher.
Professional and Scientific Society Memberships
- American Heart Association
- American Society of Echocardiography
- American Academy of Pediatrics
- Pediatric Academic Society
- Society for Pediatric Research
Education & Training
- MBBS, Medicine, Surgery, All India Institute of Medical Sciences, 1990
- Internship & Residency in Pediatrics, All India Institute of Medical Sciences, 1992-1993
- Internship in Preliminary/Internal Medicine, Michael Reese Medical Center, 1992-1993
- Residency in Pediatrics, Baylor College of Medicine, 1993-1996
- Fellowship in Pediatric Cardiology, Baylor College of Medicine, 2002-2007
Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Kühn B: Control of cytokinesis by b-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019 Oct 9;11(513).; PMID:31597755
Liu R, Jagannathan R, Li F, Lee J, Balasubryamanyam N, Kim BS, Yang P, Yechoor VK, Moulik M Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019 Feb 27; 14(2): e0212017; PMID: 30811446
Lee J, Ma K, Moulik M, Yechoor V. Circadian Clock in β-cell stress and function. Free Radical Biology and Medicine. 2018; 119:69-74 NIHMSID: NIHMS950138. PMID: 29458148
Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M Tead1 is required to maintain adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 Sep 7; 2017. Pii:93343
Lee J, Liu R, De Jesus D, Kim B.S. Ma K, Moulik M, Yechoor V : Circadian control of β-cell function and stress responses. Diabetes, Obesity and Metabolism. 2015 September; 17 (S1): 123-133
Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V.: PD-L1 driven Tolerance Protects Neurogenin3-induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes. 2014 Oct 20. pii: DB_131737. [Epub ahead of print
Molina K, Denfield S, Fan Y, Moulik M, Towbin J, Dreyer W, Rossano J: Viral endomyocardial infection in the 1st year post transplant is associated with persistent inflammation in children who have undergone cardiac transplant. Cardiology Young. 2014 April; 24(2):331-6 PMID:23680495
Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK: Bmal1 and β-cell clock are required for adaptation to circadian disruption and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol. 2013 Jun: 33(11):2327-38/MCB.01421-12. Epub 2013 Apr 1. PMID:23547261
Agopian AJ, Moulik M, Gupta-Malhotra M, Marengo LK, Mitchell LE: Descriptive epidemiology of non-syndromic complete atrioventricular canal defects. Paediatr Perinat Epidemiol 2012 Nov;26(6):515-24. PMID: 23061687
Mousumi Moulik, John P. Breinholt, William J. Dreyer, Debra L. Kearney, Jack Price, Sarah Clunie, Brady S. Moffett, Jeffrey J. Kim, Joseph W. Rossano, John Lynn Jefferies, Annie Thomas, Brandy A. Harbes, Karla R. Bowles, E. O Brian Smith, Neil E. Bowles, Susan W. Denfield, Jeffrey A. Towbin: Viral Endomyocardial Infection is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol 2010 Aug 10;56(7):582-92.
R01HL147946, Tead1 and Cardiac Adaptation, (PI, 31% effort), 2019-2024, Federal (NIH/NHLBI), $1,899,750
Faculty Recruitment Seed Fund, Hemostasis and Vascular Biology Research Institute-Admin Core, (PI, 69% effort), 2017-2020, Hemophilia Center of Western Pennsylvania & Institution for Transfusion Medicine, $ 400,000