Nader Shaikh, MD, MPH

  • Professor of Pediatrics and Clinical and Translational Science

The focus of Nader Shaikh’s research has been on the diagnosis and treatment of frequently occurring childhood infections. (urinary tract infection, otitis media and sinusitis). With regards to urinary tract infections (UTIs), Shaikh has served as a PI on several large NIDDK-funded studies (STARRs, Biomarkers) examining the diagnosis and treatment of UTIs. Shaikh has overseen enrollment of >600 children with a UTI over the past 5 years. Shaikh is currently working on a study (Biomarkers for Urinary tract Infection and pyelonephritis, R01, NIDDK) aimed at the (a) identification of urinary markers that are more accurate than the currently available point-of-care tests for the diagnosis of UTI, and (b) identification of novel urinary biomarkers for pyelonephritis. With regards to otitis media, Shaikh has served as a PI on 6 studies focused on establishing the validity and reliability of a parent-reported outcome measure that can be used severity of symptoms of acute otitis media. Shaikh has also served as co-investigator on several large NIAID trials (antibiotics vs. placebo, shortened duration of antimicrobial therapy, efficacy of tympanostomy tubes). These two trials form the basis for the current treatment approach to acute otitis media. With regards to acute sinusitis, Shaikh is currently the co-PI of the largest placebo-controlled randomized trial in children to date. He has also conducted several studies on the signs and symptoms of acute sinusitis in children.  

Professional and Scientific Society Memberships

  • Academic Pediatric Association, 2001-Present 
  • American Academy of Pediatrics, Fellow, 2001-Present 
  • Society for Pediatric Research, 2009-2011 

Education & Training

  • BS, Biology, McGill University, 1991
  • MPH, UCLA School of Public Health, 1993
  • MD, Temple University School of Medicine, 1997
  • Residency in Pediatrics, AI duPont Hospital for Children, 2000
  • Fellowship in General Academic Pediatrics, UPMC Children’s Hospital of Pittsburgh, 2000-2002

Selected Publications

Shaikh N, Rajakumar V, Peterson C, Gorski J, Ivanova A, Gravels Muller L, Miyashita Y, Smith K, Mattoo T, Pohl H, Mathews R, Greenfield S, Docimo S, Hoberman A. Cost-utility of Antimicrobial Prophylaxis for Treatment of Children with Vesicoureteral Reflux. Front Pediatr 2020. https://doi: 10.3389/fped.2019.00530. 

Shaikh N, Osio VA, Wessel CB, Jeong JH. Prevalence of asymptomatic bacteriuria in children: A Meta-Analysis. J Pediatr 2019 Nov 28. Pii: S0022-3476(19)31343-5. Doi: 10.1016/j.jpeds.2019.10.019.

Shaikh N, Martin JM, Hoberman A, Skae M, Milkovich L, McElheny C, Hickey RW, Gabriel LV, Kearney DH, Majd M, Shalaby-Rana E, Tseng G, Kolls J, Horne W, Huo Z, Shope TR. Biomarkers that differentiate false positive urinalyses from true urinary tract infection. Pediatr Nephrol 2019. 

Shaikh N, Shope MF, Kurs-Lasky M. Urine Specific Gravity and the Accuracy of Urinalysis. Pediatrics 2019; 144(5). pii: e20190467. doi: 10.1542/peds.2019-0467.

Hum SW, Shaikh KJ, Musa SS, Shaikh N. Adverse Events of Antibiotics Used to Treat Acute Otitis Medial in Children: A Systemic Meta-Analysis. J Pediatr 2019. pii: S0022-3476(19)31101-1. doi: 10.1016/j.peds.2019.08.043

Sorkhi H, Riahi S, Ebrahimpour S, Shaikh N, Rostami A. Urinary tract infection in children with nephrotic syndrome: A sytematic review and meta-analysis. Microb Pathog 2019;137:103718 

Shaikh N, Shope M, Kurs-Lasky M. Urine Specific Gravity and the Accuracy of Urinalysis. Pediatrics. 2019; In Press.

Liang D, McHugh KM, Brophy PD, Shaikh N, Manak JR, Andrews P, Hakker I, Wang Z, Schwaderer AL, Hains DS. DNA copy number variations in children with vesicoureteral reflux and urinary tract infections. PLoS ONE 2019, Aug 12;14(8); doi: 10.1371/journal.pone.0220617

Shaikh N, Haralam MA, Kurs-Lasky M, Hoberman A. Association of Renal Scarring with Number of Febrile Urinary Tract Infections in Children. JAMA Pediatr, Aug 5, doi:10.1001/jamapediatrics.2019.2504.

Lopez SMC, Martin JM, Johnson M, Kurs-Lasky M, Horns WT, Marshall CW, Cooper VS, Williams JV, Shaikh N. A Method of Processing Nasopharyngeal Swabs to Enable Multiple Testing. Pediatr Res 2019 Jul 9. doi: 10.1038/s41390-019-0498-1.

Full Publication List via NIH PubMed »

Research Grants

R01DK118033, Biomarkers for Urinary Tract Infection and Pyelonephritis, (PI, 1.8%), 2019-2023, NIDDK, $421,933 

1U01AI118506, Efficacy of Antibiotics in Children with Acute Sinusitis: Which Subgroups Benefit?, (PI, 3.4% effort), 2015-2020, NIAID, $781,698 

U01FD006878, Modification of the Acute Otitis Media Severity of Symptoms Scale, (PI, 1.2% effort), 2019-2020, FDA, $249,718 

BAA-NIAID-DMID-AI2008025, Targeted clinical trials to reduce the risk of antimicrobial resistance: “Short course therapy for UTI in Children” (SCOUT), (PI, 1.2% effort), 2009-2019, NIAID, Children Hospital of Philadelphia, $872,314 

1 U01 DC013995-01A1, Efficacy of Tympanostomy Tubes for Children with Recurrent Acute Otitis Media, (PI, 2.4% effort), 2015-2020, NIDCD, $783,982