Patrick M. Kochanek, MD, MCCM

  • Distinguished Professor of Critical Care Medicine
  • Ake N. Grenvik Professor and Vice Chair of Critical Care Medicine
  • Professor of Anesthesiology, Pediatrics, Bioengineering, and Clinical and Translational Science
  • Director, Safar Center for Resuscitation Research

Patrick M. Kochanek, MD, is Distinguished Professor of Critical Care Medicine, the Ake N. Grenvik Professor and Vice Chair of Critical Care Medicine; Director of the Safar Center for Resuscitation Research; and Professor of Pediatrics, Anesthesiology, Bioengineering and Clinical and Translational Science at the University of Pittsburgh School of Medicine. As the Safar Center Director for 25 years, he has a long track-record of leading a translational and multi-departmental team studying traumatic and ischemic brain injury and neurointensive care, funded by the NIH, US Department of Defense, andthe Laerdal Foundation. He has & gt; 550 listings on PubMed and was identified by ISI as the most prolific author in the field of TBI from 2001 to 2014. Heis PI of Operation Brain Trauma Therapy for the U.S. Department of Defense and has been PI for 19 years of a T-32 titled “Training in Pediatric Neurointensive Care and Resuscitation Research” funded by the NICHD. He has mentored numerous trainees, many of whom have gone on to receive independent funding and careers of national prominence. He has been Editor-in-Chief of Pediatric Critical Care Medicine for the past 20 years and is on the editorial board of numerous journals on acute brain injury. He received the Distinguished Investigator Award from the American College of Critical Care Medicine in 2007, was named one of the inaugural Masters of Critical Care Medicine, and received the Lifetime Achievement Award from the Society of Critical Care Medicine in 2017. He was also one of the distinguished speakers at the 125th anniversary celebration of Walter Reed Army Institute of Research in 2018 and gave a Great Teachers Lecture at the NIH Clinical Center in 2019.

Professional and Scientific Society Memberships

  • American Association for the Advancement of Science, 1985
  • Society of Critical Care Medicine, 1987
  • Pennsylvania Society of Critical Care Medicine, 1988
  • International Society of Cerebral Blood Flow and Metabolism, 1988
  • New York Academy of Sciences, 1988
  •  American Heart Association, Stroke Council, 1989
  • National Neurotrauma Society, 1989
  • Society for Neuroscience, 1990
  • Society for Pediatric Research, 1990
  • Council on Cardiopulmonary and Critical Care, American Heart Association, 1994
  • International Neurotrauma Society, 1996
  • The American Association of Neurological Surgeons, Associate Member, 1997
  • World Association of Medical Editors, 2002
  • Society of Neurosurgical Anesthesia and Critical Care, 2006
  • American Academy of Pediatrics, Fellow, 2008

Education & Training

  • BS, Zoology, University of Michigan, 1976
  • MD, University of Chicago, 1980
  • Internship in Pediatrics, University of California, 1980-1981
  • Residency in Pediatrics, University of California, 1981-1983
  • Fellowship in Pediatrics, Children's Hospital National, 1983-1986

Selected Publications

Jackson TC, Janesko-Feldman K, Gorse K, Vagni VA, Jackson EK, Kochanek PM: Identification of novel targets of RBM5 in the healthy and injured brain. Neuroscience Apr 23:S0306-4522(20)30247-5, 2020. [Epub ahead of print] PMID:32335213 [PMCID in process]

Zusman BE, Kochanek PM, Jha RM:  Cerebral edema in traumatic brain injury: A historical framework for current therapy.  Curr Treat Options Neurol 2020 (in press). 

Pang D, Wu Y, Alcamo AM, Cummings J, DiCaro V, Walko T, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK:  Early axonal injury and delayed cytotoxic cerebral edema are associated with microglial activation in a mouse model of sepsis.  Shock 2019 Sep 10 [Epub ahead of print] PMC7062563 

Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE:  Paths to successful translation of new therapies for severe TBI in the golden age of traumatic brain injury research: A Pittsburgh vision. J Neurotrauma 2019 Feb 1 [Epub ahead of print] PMID:30520681 [PMCID in process]

Leisman DE, Harhay MO, Lederer DJ, Abramson M, Adjei AA, Bakker J, Ballas ZK, Barreiro E, Bell SC, Bellomo R, Bernstein JA, Branson RD, Brusasco V, Chalmers JD, Chokroverty S, Citerio G, Collop NA, Cooke CR, Crapo JD, Donaldson G, Fitzgerald DA, Grainger E, Hale L, Herth FJ, Kochanek PM, Marks G, Moorman JR, Ost DE, Schatz M, Sheikh A, Smyth AR, Stewart I, Stewart PW, Swenson ER, Szymusiak R, Teboul JL, Vincent JL, Wedzicha JA, Maslove DM. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Crit Care Med. 48(5):623-633, 2020. PMID:32141923 [PMCID in process]

Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayır H:  Bioactive oxylipins in infants and children with congenital heart disease undergoing pediatric cardiopulmonary bypass.  Pediatr Crit Care Med 21:33-41, 2020. PMID:31305328 [PMCID in process]

Lumba-Brown A, Kochanek PM:  Emergency Department implementation of the Brain Trauma Foundation’s Pediatric Severe Brain Injury Guideline recommendations.  Ann Emerg Med 36(4):e239-e241, 2020.

Pasek TA, Burns C, Treble-Barna A, Ortiz-Aguayo R, Kochanek PM, Houtrow AJ, Beers SR, Fink EL: Important outcomes for parents of critically ill children.  Crit Care Nurs 39:74-79, 2019.

Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-o’Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS:  Guidelines for the management of pediatric severe traumatic brain injury, third edition: Executive Summary.  Neurosurgery 84:1169-1178, 2019.

Kochanek PM, Tasker RC, Bell MJ, Carney N, Vavilala MS, Selden NR, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Wainwright MS:  Management of pediatric severe traumatic brain injury:  2018 Guidelines and Consensus-Based Algorithm for First and Second Tier Therapies.  Pediatr Crit Care Med 20:269-279, 2019.

Full Publication List via NIH PubMed »

Research Grants

5 T32 ND040686, Pediatric Neurointensive Care and Resuscitation Research, 2000-2021, National Institutes of Health, $1,709,003

1R01NS087978, 2',3'-cAMP in Traumatic Brain Injury, 2014-2020, National Institutes of Health, $1,680,869

2R01NS061817, Oxidative Lipidomics in Pediatric Traumatic Brain Injury, 2014-2020, National Institutes of Health, $1,684,375 

1R01NS096714-01, Development of Serum, Imaging and Clinical Biomarker Driven Models to Direct Clinical Management after Pediatric Cardiac Arrest, 2016-2021, National Institutes of Health, $2,630,947

Project ID#B1778-I, Evaluation of Neurotherapeutic Resuscitation Strategies in Polytrauma Associated with Traumatic Brain Injury, 2016-2020, VA Grant, $162,342

W81XWH-17-C-0064, Evaluation of neurotherapeutic resuscitation strategies in polytrauma associated with traumatic brain injury, 2017-2020, United States Army, $601,034

1R21NS108386, Dopamine system focused neurorehabilition model for improving neurorecovery among cardiac arrest survivors, 2018-2020, National Insittutes of Health, $200,641 

1R01NS105721, The role of RNA binding motif 5 in traumatic brain injury, 2018-2023, National Institutes of Health, $1,711,720 

AHA 18TPA34170553, Dopamine Systems and Rehabilitation Treatments for Improving Neurorecovery Among Cardiac Arrest Survivors, 2018-2021, American Heart Association, $300,000

Sulfonylurea Receptor-1 and glyburide: preventing brain swelling and providing neuroprotection in mild repetitive traumatic brain injury, 2019-2020, Chuck Noll Foundation 0007, $150,000