Pavithra Aravamudhan, PhD
- Postdoctoral Associate
Aravamudhan is interested in understanding host-pathogen interactions using a combination of biophysical tools, microscopy in particular, and state-of-the-art cell biological and biochemical techniques. As a postdoctoral fellow in the Dermody Lab, she has been investigating how neurotropic mammalian orthoreoviruses establish neuronal infection resulting in lethal encephalitis in young animals.
Her research projects use primary neuronal culture and mouse models to understand how reovirus engagement of specific receptors on host cell surface dictates serotype-specific tropism and pathogenesis and how reovirus exploits host machinery to traffic through and spread between neurons to establish infection. These research directives will allow better understanding of neuronal infection by viruses and illuminate targets for development of therapeutics.
Education & Training
- BS, Biotechnology, Anna University, 2008
- MS, Biophysics, University of Michigan, 2010
- PhD, Biophysics, University of Michigan, 2015
Aravamudhan P, Raghunathan K, Konopka-Anstadt J, Pathak A, Carter BD, Dermody TS. Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS Pathogens 2020;16(2):e1008380
Koehler M*, Aravamudhan P*, Guzman-Cardozo C, Dumitru AC, Yang J, Gargiulo S, Soumillion P, Dermody TS, Alsteens D. Glycan-mediated enhancement of reovirus receptor binding. Nature Communications 2019;10(1):4460
Sutherland DM*, Aravamudhan P*, Dermody TS. An orchestra of reovirus receptors: still searching for the conductor. Advances in Virus Research. 2018;100:223-246.
Aravamudhan P, Chen R, Roy B, Sim J, Joglekar AP. Dual mechanisms regulate the recruitment of spindle assembly checkpoint proteins to the budding yeast kinetochore. Molecular Biology of the Cell. 2016; E16-01-0007
Joglekar AP & Aravamudhan P. How the kinetochore switches off the spindle assembly checkpoint. Cell Cycle. 2016;15(1):7-8
Aravamudhan P, Goldfarb A, Joglekar AP. The kinetochore encodes a mechanical switch to control the spindle assembly checkpoint. Nature Cell Biology. 2015;17(7):868-79
Aravamudhan P, Felzer-Kim I, Gurunathan K, Joglekar AP. Assembling the protein architecture of the budding yeast kinetochore-microtubule attachment using FRET. Current Biology. 2014;24(13):1437-46
Aravamudhan P, Felzer-Kim I, Joglekar AP. The budding yeast point centromere associates with two Cse4 molecules during mitosis. Current Biology. 2013;23(9):770-4