Pengcheng Shang, PhD
Dr. Pengcheng Shang has extensive research experiences in virology and completed the PhD study of pathobiology at Kansas State University in December 2018. He joined the Department of Pediatrics, University of Pittsburgh in Jan 2019. He works as a post-doc researcher in the laboratory of Dr. Terence Dermody, who is leading the research of mammalian orthoreovirus (reovirus). Reovirus infects most mammals and has been linked to human celiac disease. Dr. Dermody’s lab focuses on the investigation of the mechanisms controlling reovirus replication and pathogenesis. Reovirus exhibits broad tissue tropism with serotype-specific characteristics. However, host receptors dictating reovirus tissue tropism and diseases remain largely undefined. Dr. Shang is dedicated to the identification of reovirus receptors for the infection of the intestine and central nervous system. Innovative technologies such as CRISPRa and transcriptomic analysis have been successfully employed to unravel the mystery of reovirus tropism and pathogenesis. Dr. Shang is planning to independently lead a virology research team after the post-doc training.
Education & Training
- BS, Shandong Agricultural University, 2010
- MA, China Agricultural University, 2013
- PhD, Kansas State University, 2018
Li Y, Shyu D, Shang P, Bai J, Ouyan K, Hireamt J, Binjawadagi B, Renukaradhya GJ, Fang Y. 2016. Mutations in the highly conserved motif of nsp1β protein attenuated the innate immune suppression function of porcine reproductive and respiratory syndrome virus (PRRSV). J Virol. 2016 Jan 20;90(7):3584-99.
Binjawadagi B, Lakshmanappa YS, Longchao Z, Dhakal S, Hiremath J, Ouyang K, Shyu DL, Arcos J, Shang P, Gilbertie A, Zuckermann F, Torrelles JB, Jackwood D, Fang Y, Renukaradhya GJ. Development of a porcine reproductive and respiratory syndrome virus-like-particle-based vaccine and evaluation of its immunogenicity in pigs. Arch Virol. 2016 Jun; 161(6):1579-89.
Chen Z, Yuan F, Li Y, Shang P, Schroeder R, Lechtenberg K, Henningson J, Hause B, Bai J, Rowland RR, Clavijo A, Fang Y. Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A. Virology. 2016 Oct; 497:111-24.
Palinski R, Piñeyro P, Shang P, Yuan F, Guo R, Fang Y, Byers E, Hause BM. A novel porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure. J. Virol. 2016 Dec 16;91(1)
Y. Li, P. Shang, D. Shyu, C. Carrillo P. Naraghi-Arani, G. J. Renukaradhya, J. Henningson, A. Firth, E. J. Snijder, Y. Fang. Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses. Virology. 2018 Apr; 517:164-176. (Co-first author with Y. Li).
Shang P, Misra S, Hause B, Fang Y. A naturally occurring recombinant enterovirus expresses torovirus deubiquitinase. J Virol. 2017 Jun 26;91(14). Selected as JVI spotlight feature.
Shang P, Li Y, Snijder E, Brierley I, Firth A, Fang Y. A conserved high-order RNA structure within ORF6 is critical for PRRSV subgenomic RNAs accumulation and infectious virus production. Manuscript in preparation.
Guo R, Shang P, Carrillo CA, Sun Z, Lakshmanappa YS, Yan X, Renukaradhya GJ, McGill J, Jaing CJ, Niederwerder MC, Rowland RRR, Fang Y. 2017. Double-stranded viral RNA persists in vitro and in vivo during prolonged infection of PRRSV. Virology. 2018 Nov;524:78-89. (Co-first author with Guo R)
Li Z, Zaiser S, Shang P, Heiden D, Hajovsky H, Katwal P, DeVries B, Baker J, Richt J, Li Y, He B, Fang Y, Huber V. Evaluation of parainfluenza virus 5 as the vector for delivery of a chimeric influenza hemagglutinin as a universal vaccine candidate. Manuscript submitted to Vaccine. (Co-first author with Li Z)
Shang P, Yuan F, Misra S, Li Y, Fang Y. Hyper-phosphorylation on nsp2-related proteins of porcine arterivirus regulates the accumulation of viral RNA transcripts. Virology. 2020 Apr; 543: 63–75.